Guoyin Yin, Wuhan University, Wuhan, Hubei, PR China

Short biography:  Guoyin Yin (阴国印), Professor and Associate Dean at the Institute of Advanced Studies of Wuhan University. He received his bachelor's degree from Northeast Agricultural University in 2006 and earned his Ph.D. from the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences in 2011. Subsequently, he conducted postdoctoral research at the Technical University of Munich, RWTH Aachen University in Germany, and the University of Delaware in the United States. In September 2016, he joined the Institute of Advanced Studies of Wuhan University as a principle investigator and was promoted to Professor in 2021. His research focuses on transition metal-catalyzed chain-walking catalysis and multicomponent reactions of alkenes.

NICEKEL CHAIN-WALKING CATALYSIS FOR MULTICOMPONENT ALKENE FUNCTIONALIZATION

Guoyin Yin

 Wuhan University

E-mail: yinguoyin@whu.edu.cn

Keywords:Chain-walking catalysis, nickel, alkene functionalization, 1,n-addition(n≠2)

Chain-walking offers extensive opportunities for innovating synthetic methods that involve constructing chemical bonds at unconventional sites. This approach provides previously inaccessible retrosynthetic disconnections in organic synthesis. Through chain-walking, transition metal-catalyzed alkene difunctionalization reactions can take place in a 1, n-addition (n≠2) mode. Unlike classical 1,2-regioselective difunctionalization reactions, there remains a scarcity of reports regarding migratory patterns. Moreover, the range of olefins utilized in these studies is quite limited. The Yin group focuses on developing valuable migratory difunctionalization reactions of alkenes through chain-walking. Our focus was on carboboration of alkenes utilizing nickel catalysis. The incorporation of a versatile boron group introduces a wealth of possibilities for subsequent diversifications, significantly enhancing the value of the resulting products and allowing for the creation of a broader range of valuable derivatives and applications.

References

[1]  Y. Li, D. Wu, H.-G. Cheng, G. Yin* Angew. Chem. Int. Ed. 2020, 59, 7990-8003.

[2]  Y. Li, H. Shi, H. Wei, H. Li, I. Funes-Ardoiz*, G. Yin* Science2022, 376, 749-753.

[3]  Y. Li, G. Yin*, Acc. Chem. Res.2023, 56, 3246-3259.

[4]  L. Lu, S. Chen, W. Kong, B. Gao, Y. Li*, L, Zhu*, G. Yin* J. Am. Chem. Soc.2024, 146, 16639-16647.

[5] W. Kong, D. Wu, H. Wei, B.Gao, P. Li, Y. Li, Y. Li*, G. Yin*. Nat. Chem.2025, 17, 1768-1776.