Wei Zhang, University of Massachusetts Boston, USA

Short biography: Dr. Wei Zhang is a professor and former Director of the Center for Green Chemistry at the University of Massachusetts Boston. His previous positions include Research Assistant Professor at the University of Pittsburgh, Senior Chemist at DuPont, and Director at Fluorous Technologies, Inc. His current research is in the areas of organic synthesis, organocatalysis, drug discovery, and green chemistry. He has coauthored over 260 papers including three in Chem. Rev. on synthetic radicals and fluorous technologies, 6 patents and patent applications on drug discovery, and three books on green synthesis. He has been serving as editor and editorial advisory member on nine international journals.

INTEGRATED ONE-POT STEPWISE SYNTHESIS AND ORGANOCATALYSIS 

Wei Zhang

Department of Chemistry and Center for Green Chemistry

University of Massachusetts Boston, MA 02125 USA

e-mail: wei2.zhang@umb.edu

Keywords:One-pot synthesis, multicomponent reaction, cascade reaction, stepwise synthesis

One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less waste. Among three kinds of one-pot syntheses 1) cascade reactions, 2) multicomponent reactions (MCRs), and 3) one-pot stepwise synthesis (OPSS), OPSS could be more flexible and practical since it is carried out step wisely and have variable reaction conditions at different steps. This presentation highlights the recent development in our lab on the development of OPSS involving cyclization, cycloaddition, rearrangement, and organocatalysis for the synthesis of heterocyclic scaffolds, asymmetric molecules, and bioactive compounds. 

References 

• Ma, X.; Zhang, W. “New developments on one-pot stepwisesynthesis (OPSS)” iScience2022, 25: 105005. 10.1016/j.isci.2022.105005 
• Zhang, W.; Yi, W.-B. “Pot, Atom, and Step Economy (PASE) Synthesis” Springerbriefs in Green Chemistry for Sustainability, Springer, 2019
• Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd Ed,Zhang, W.;Cue, B. W. Eds., Wiley, Chichester, 2018.