尹 胜

尹胜

教授

研究领域：天然药物化学、天然有机化学

办公电话： 020-39943090

联系邮箱： yinsh2@mail.sysu.edu.cn

联系方式

办公电话：

电子邮箱：yinsh2@mail.sysu.edu.cn

办公地址：中山大学药学院414A

简单介绍

尹胜， 中山大学药学院 教授 博士生导师

国家优秀青年基金、广东省杰出青年基金、广东省“青年拔尖人才”获得者

2003年毕业于复旦大学化学系化学专业，获学士学位，同年保送至中国科学院上海药物研究所硕博连读，师从岳建民院士，专业为天然药物化学。2008年博士毕业，获中科院院长特别奖（获40万启动经费），中科院优秀博士论文提名奖等。2008年10月至2010年6月在澳大利亚Eskitis研究所从事以高通量筛选为导向的海洋天然产物研究，导师为Eskitis研究所Ron. Quinn院士。 2010年10月作为中山大学“百人计划”副教授、博导引进，2014年1月晋升为教授。迄今从三十余种高等植物及海洋生物中分离鉴定约500多个化合物，其中200多个为新化合物，新颖碳骨架类型10种，其中3个化合物被天然产物权威评论性杂志 Natural Product Reports 选为热点化合物（Hot off the press），部分化合物具有重要的生物活性，已开发成为先导化合物。在NPR、JMC、Organic Letters,  Journal of Natural Products等杂志上发表通讯及第一作者论文80篇（10篇为中科院一区）。研究领域为以活性筛选为导向从天然产物中发现抗炎、抗肿瘤、抗肥胖症活性小分子化合物，并进行结构修饰和相关的药理活性研究。

特别提醒：请报考本人研究生的同学在选择专业时填写生药学专业。

研究方向

天然药物化学、天然有机化学

教育经历

2014/01——至今      中山大学药学院，教授，博士生导师

2010/11——2013/12 中山大学药学院，“百人计划”副教授，博士生导师

2008/06——2010/06 澳大利亚Eskitis研究所，博士后研究员

2008/06——2010/10 中国科学院上海药物研究所，助理研究员

2003/09——2008/07 中国科学院上海药物研究所，药物化学，博士

1999/09——2003/07 复旦大学，化学系，学士

教学情况

天然药物化学

波谱解析实例

药学综合大实验

社会/学术任职

中国化学会会员；广东省现代中药工程技术研究中心海洋药物化学实验室主任；国内核心期刊《天然产物研究与开发》青年编委；国际期刊Organic letters、 Steroids、 Bioorganic & Medicinal chemistry常邀审稿人。

科研项目

  1. 2025年国家自然科学基金，  82574273，《以载脂蛋白APOL2为新靶点的惕各烷型二萜抗肝纤维化药物研究》， 2026/01-2029/12, 48万，在研，主持。
  2. 2023年广东省科技计划项目，  2023A1111120025，《药品化妆品安全风险物质非靶向筛查和确证关键技术研究》， 2023/11-2026/10, 25万/100万，在研，联合主持。
  3. 2022年国家自然科学基金，  82273804，《靶向importin-β1抗去势抵抗型前列腺癌二萜先导物的发现及作用机制研究》， 2022/01-2026/12, 52万，在研，主持。
  4. 2021年深圳湾实验室开放基金项目，  SZBL2021080601007，《大戟科多环二萜库的构建及其抗肝纤维化的新药研究》， 2021/11-2024/10, 200万，结题，主持。
  5. 2021年南方海洋科学与工程广东省实验室（珠海）自主科研项目，  SML2021SP301，《珠三角海域甲藻中海洋毒素的高效制备及其在药物研发中的应用》， 2021/10-2023/09, 100万，结题，主持。
  6. 2019年国家自然科学基金，  81973195，《以糖皮质激素受体α为新靶点的抗肥胖症惕各烷型二萜的发现与研究》， 2020/01-2023/12, 55万，结题，主持。
  7. 2017年国家自然科学优秀青年基金，81722042，《天然药物化学》，2018/01-2020/12，130 万，在研，主持。
  8. 2015年度“863计划”青年科学家专项，SS2015AA020928，《中药垫状卷柏中新型磷酸二酯酶IV抑制剂的发现、结构优化及临床前研究》, 2015/01-2017/12，122 万，结题，主持。
  9. 2015国家自然科学基金面上基金，81573302，《中药南木香中靶向ERK和TGF-beta/Smad信号通路对抗心肌纤维化的物质基础及作用机制研究》，2016/01-2019/12， 60 万，结题，主持。
  10. 2014年度广东省自然科学杰出青年基金，14050000228《新型天然磷酸二酯酶IV抑制剂的发现、结构优化及作用机制研究》，2015/01-2019/01，100 万，结题，主持。
  11. 2016年广东省科技计划《中药南木香中靶向ERK和TGF-beta/Smad信号通路对抗心肌纤维化的物质基础及作用机制研究》, 2016/01-2018/12, 30万，结题，主持。
  12. 2016年广东特支计划百千万工程青年拔尖人才 2016.06-2019.06 10万，结题，主持
  13. 2014年广东省科技计划，2013B021100009，《基于杂原子化学成分的海鞘天然产物库的构建及活性筛选》，2014/08-2017/08，30 万，结题，主持。
  14. 国家自然科学基金青年基金，81102339，《三种海绵的新型抗菌活性成分的发现与研究》，2012/01-2014/12，25万元，结题，主持。
  15. 广东省自然科学基金，S2011040002429，《星座美洲海鞘化学成分和抗肿瘤活性研究》，2011/10-2013/10， 3万元，结题，主持。

论著专利

  1. Huang, Jia-Luo#; Wu, Lei-Ming#; Wu, Shu-Qi; Yuan, Fang-Yu; Weng, Han-Zhuang; Huang, Dong; Gan, Lu; Chen, Shuo-Bin; Tang, Gui-Hua; Yin, Sheng*. A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy. Nature Chemical Biology 2026, 22 (3), 459-470. DOI: 10.1038/s41589-025-02040-w.
  2. Gan, Lu#; Jiang, Qiwei#; Huang, Dong#; Wu, Xueji; Zhu, Xinying; Wang, Lei; Xie, Wei; Huang, Jialuo; Fan, Runzhu; Jing, Yihang; Tang, Guihua; Li, Xiang David; Guo, Jianping*; Yin, Sheng*. A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2. Nature Chemical Biology 2025, 21 (1), 80-90. DOI: 10.1038/s41589-024-01704-3.
  3. Hu, Xinrong#; Gan, Lu#; Tang, Ziwen; Lin, Ruoni; Liang, Zhou; Li, Feng; Zhu, Changjian; Han, Xu; Zheng, Ruilin; Shen, Jiani; Yu, Jing; Luo, Ning; Peng, Wenxing; Tan, Jiaqing; Li, Xiaoyan; Fan, Jinjin; Wen, Qiong; Wang, Xin; Li, Jianbo; Zheng, Xunhua; Liu, Qinghua; Guo, Jianping; Shi, Guo-Ping; Mao, Haiping; Chen, Wei; Yin, Sheng*; Zhou, Yi*. A natural small molecule mitigates kidney fibrosis by targeting Cdc42-mediated GSK-3β/β-catenin signaling. Advanced Science 2024, 11 (13), 2307850. DOI: https://doi.org/10.1002/advs.202307850.
  4. Huang, Jia-Luo#; Yan, Xue-Long#; Huang, Dong; Gan, Lu; Gao, Huahua; Fan, Run-Zhu; Li, Shen; Yuan, Fang-Yu; Zhu, Xinying; Tang, Gui-Hua; Chen, Hong-Wu; Wang, Junjian*; Yin, Sheng*. Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer. Acta Pharmaceutica Sinica B 2023, 13 (12), 4934-4944. DOI: https://doi.org/10.1016/j.apsb.2023.07.017.
  5. Huang, Jia-Luo#; Yan, Xue-Long#; Li, Wei; Fan, Run-Zhu; Li, Shen; Chen, Jianghe; Zhang, Zhenhua; Sang, Jun; Gan, Lu; Tang, Gui-Hua; Chen, Hongwu; Wang, Junjian*; Yin, Sheng*. Discovery of highly potent daphnane diterpenoids uncovers importin-β1 as a druggable vulnerability in castration-resistant prostate cancer. Journal of the American Chemical Society 2022, 144, 17522–17532. DOI: 10.1021/jacs.2c06449.
  6. Sang, Jun; Gan, Lu; Zou, Ming-Feng; Lin, Zi-Jun; Fan, Run-Zhu; Huang, Jia-Luo; Li, Wei; Tang, Gui-Hua; Yin, Sheng*. Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy. Cancer Letters 2022, 526 (1), 352-362. DOI: https://doi.org/10.1016/j.canlet.2021.11.014.
  7. Zhan, Zha-jun#; Li, Shen#; Chu, Wang; Yin, Sheng*. Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021). Natural Product Reports 2022, 39 (11), 2132-2174. DOI: 10.1039/D2NP00047D.
  8. Sang, Jun; Li, Wei; Diao, Hong-Juan; Fan, Run-Zhu; Huang, Jia-Luo; Gan, Lu; Zou, Ming-Feng; Tang, Gui-Hua; Yin, Sheng*. Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells. Cancer Letters 2021, 509, 13-25. DOI: https://doi.org/10.1016/j.canlet.2021.03.030.
  9. Li, Wei; Tang, Gui-Hua; Yin, Sheng*. Selaginellins from the genus Selaginella: isolation, structure, biological activity, and synthesis. Natural Product Reports 2021, 38 (4), 822-842, DOI: 10.1039/D0NP00065E.
  10. Zhu, Xin-Ying#; Wu, Shu-Qi#; Gan, Lu; Yang, Xianyuan; Liao, Yi-Ling; An, Nan; Fan, Run-Zhu; Huang, Jia-Luo; Tang, Gui-Hua; Zhang, Chuan-Rui*; Yin, Sheng*. Discovery of Jatrophane diterpenoids as JAG1-Notch signaling inhibitors for the treatment of liver fibrosis. Journal of Medicinal Chemistry 2026, 69 (13), 15825–15839. DOI: 10.1021/acs.jmedchem.6c00883.
  11. Yan, Xue-Long#; Pan, Yue-Hua#; Fan, Run-Zhu#; Song, Qin-Qin; Li, Shen; Huang, Jia-Luo; Li, Wei; Huang, Dong; Yuan, Fang-Yu; Tang, Gui-Hua; Rao, Yong*; Huang, Zhi-Shu; Yin, Sheng*. Discovery of the first raptor (regulatory-associated protein of mTOR) inhibitor as a new type of antiadipogenic agent. Journal of Medicinal Chemistry 2023, 66 (8), 5839-5858. DOI: 10.1021/acs.jmedchem.3c00067.
  12. Fan, Run-Zhu#; Chen, Lin#; Su, Tong; Li, Wei; Huang, Jia-Luo; Sang, Jun; Tang, Gui-Hua; Yin, Sheng*. Discovery of 8,9-seco-ent-kaurane diterpenoids as potential leads for the treatment of triple-negative breast cancer. Journal of Medicinal Chemistry 2021, 64 (14), 9926–9942. DOI: 10.1021/acs.jmedchem.1c00166.
  13. Lou, Lan-Lan#; Ni, Fu-Qiang#; Chen, Lin; Shaker, Sharpkate; Li, Wei; Wang, Rong; Tang, Gui-Hua; Yin, Sheng*. Germacrane sesquiterpenoids as a new type of anticardiac fibrosis agent targeting transforming growth factor β type I receptor. Journal of Medicinal Chemistry  2019, 62 (17), 7961-7975. DOI: 10.1021/acs.jmedchem.9b00708.
  14. Song, Qin-Qin#; Rao, Yong#; Tang, Gui-Hua#; Sun, Zhang-Hua; Zhang, Jun-Sheng; Huang, Zhi-Shu*; Yin, Sheng*. Tigliane diterpenoids as a new type of antiadipogenic agents inhibit GRα-Dexras1 axis in adipocytes. Journal of Medicinal Chemistry  2019, 62 (4), 2060-2075. DOI: 10.1021/acs.jmedchem.8b01693.
  15. Pang, Yanqing#; An, Baijiao#; Lou, Lanlan; Zhang, Junsheng; Yan, Jun; Huang, Ling; Li, Xingshu*; Yin, Sheng*. Design, synthesis, and biological evaluation of novel selenium-containing isocombretastatins and phenstatins as antitumor agents. Journal of Medicinal Chemistry 2017, 60 (17), 7300-7314. DOI: 10.1021/acs.jmedchem.7b00480.
  16. Zhu, Jian-Yong#; Wang, Rui-Min#; Lou, Lan-Lan; Li, Wei; Tang, Gui-Hua; Bu, Xian-Zhang*; Yin, Sheng*. Jatrophane diterpenoids as modulators of P-glycoprotein-dependent multidrug resistance (MDR): advances of structure-activity relationships and discovery of promising MDR reversal agents. Journal of Medicinal Chemistry  2016, 59 (13), 6353-6369. DOI: 10.1021/acs.jmedchem.6b00605.
  17. Wen, Ming-Ju; Wu, Wei-Ye; Wu, Shu-Qi; Wu, Feng; Xia, Jian-Kai; Gan, Lu; Huang, Jia-Luo; Sun, Zhang-Hua; Tang, Gui-Hua; Yin, Sheng*. Biomimetic skeleton conversion from tiglianes into three euphorbia diterpenoid skeletons via regioselective cyclopropane ring-opening. Organic Letters 2026, 28 (8), 2688–2692. DOI: 10.1021/acs.orglett.6c00161.
  18. Wu, Shu-Qi#; Fan, Run-Zhu#; Yuan, Fang-Yu; Li, Wei; Huang, Dong; Li, Shen; Tang, Gui-Hua; Huang, Zhi-Shu; Yin, Sheng*. Euphylonoids A and B, two highly modified jatrophane diterpenoids with potent lipid-lowering activity from Euphorbia hylonoma. Organic Letters 2022, 24 (48), 8854-8858. DOI: 10.1021/acs.orglett.2c03649.
  19. Huang, Dong; Pan, Yue-Hua; Yuan, Fang-Yu; Li, Wei; Yan, Xue-Long; Zou, Ming-Feng; Tang, Gui-Hua; Yin, Sheng*. Euphohyrisnoids A and B, two highly rearranged lathyrane diterpenoids from Euphorbia lathyris. Organic Letters 2021, 23 (24), 9602–9605. DOI: 10.1021/acs.orglett.1c03812.
  20. Ni, Fu-Qiang; Wu, Shu-Qi; Li, Wei; Li, Qingjiang*; Yin, Sheng*. Stereoselective construction of the methylcyclopentane core of peditithins B–H with five continuous stereocenters. Organic Letters 2020, 22 (23), 9360-9364. DOI: 10.1021/acs.orglett.0c03615.
  21. Li, Wei; Wang, Rui-Min; Pan, Yue-Hua; Zhao, Ying-Yuan; Yuan, Fang-Yu; Huang, Dong; Tang, Gui-Hua; Bi, Hui-Chang; Yin, Sheng*. Crotonpenoids A and B, two highly modified clerodane diterpenoids with a tricyclo[7.2.1.02,7]dodecane core from Croton yanhuii: Isolation, structural elucidation, and biomimetic semisynthesis. Organic Letters 2020, 22 (11), 4435-4439. DOI: 10.1021/acs.orglett.0c01443.
  22. Li, Wei#; Tang, Ya-Qi#; Sang, Jun; Fan, Run-Zhu; Tang, Gui-Hua; Yin, Sheng*. Jatrofolianes A and B: Two highly modified lathyrane diterpenoids from Jatropha gossypiifolia. Organic Letters 2020, 22 (1), 106-109. DOI: 10.1021/acs.orglett.9b04029.
  23. Yan, Xue-Long; Sang, Jun; Chen, Shi-Xin; Li, Wei; Tang, Gui-Hua; Gan, Li-She; Yin, Sheng*. Euphorkanlide A, a highly modified ingenane diterpenoid with a C24 appendage from Euphorbia kansuensis. Organic Letters 2019, 21 (11), 4128-4131. DOI: 10.1021/acs.orglett.9b01315.
  24. Liu, Xin#; Luo, Hai-Bin#; Huang, Yi-You; Bao, Jing-Mei; Tang, Gui-Hua; Chen, Yun-Yun; Wang, Jun; Yin, Sheng*. Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata. Organic Letters 2014, 16 (1), 282-285. DOI: 10.1021/ol403282f.
  25. Wu, Shu-Qi#; Zhu, Xinying#; Yuan, Fang-Yu; Weng, Han-Zhuang; Li, Lei; Huang, Dong; Tang, Gui-Hua*; Yin, Sheng*. Malbrumpenoids A-N, unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16. Chinese Chemical Letters 2026, 37 (5), 111336. DOI: https://doi.org/10.1016/j.cclet.2025.111336.
  26. Li, Lei#; Zhu, Xin-Ying#; Zhu, Jun-Yu; Wu, Zhi-Hao; Zhang, Yan-Jiang; Yuan, Fang-Yu; Huang, Dong; Yin, Sheng*; Tang, Gui-Hua*. Penispirolactam and penipyrroloindole, two unusual polycyclic indole diterpenoids with anti-hepatic fibrosis activity from the endophytic fungus Penicillium janthinellum H-6. Chinese Chemical Letters 2026, 37 (4), 111161. DOI: https://doi.org/10.1016/j.cclet.2025.111161.
  27. Tan, Qi; Fan, Run-Zhu; Yang, Wencong; Zou, Ge; Chen, Tao; Wu, Jianying; Wang, Bo; Yin, Sheng*; She, Zhigang*. (+)/(−)-Mycosphatide A, a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella sp. SYSU-DZG01. Chinese Chemical Letters 2024, 35 (9), 109390. DOI: https://doi.org/10.1016/j.cclet.2023.109390.
  28. Huang, Dong#; Zhao, Ying-Yuan#; Wang, Rui-Min; Li, Wei; Yuan, Fang-Yu; Yan, Xue-Long; Yang, Xiao; Tang, Gui-Hua; Yin, Sheng*; Bi, Hui-Chang*. Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity. Acta Pharmacologica Sinica 2022, 43, 2139–2146. DOI: 10.1038/s41401-021-00793-3.
  29. Cai, Shulong; Fan, Liqi; Liu, Dan; Wei, Changxing; Yang, Na; Fu, Xichao; Tang, Rong; Xu, Jucai*; Yin, Sheng*; Chen, Xin*. A peptidomics-based investigation of the synergistic effects of neutral and Alcalase proteases on release of antioxidant peptides from soybean protein isolates. Food Chemistry 2025, 496, 146696. DOI: https://doi.org/10.1016/j.foodchem.2025.146696.
  30. Gan, Lu#; Wu, Shu-Qi#; Liao, Yi-Ling; Su, Tong; Zhu, Xin-Ying; Chen, Yun-Yun; Yuan, Fang-Yu; Huang, Jia-Luo; Tang, Gui-Hua; Liu, Wei*; Huang, Dong*; Yin, Sheng*. Discovery of myrsinane diterpenoids from Euphorbia prolifera as a new type of antiliver fibrosis agents that inhibit the PI3K-AKT signaling pathway. Journal of Natural Products 2026, 89 (2), 560–572. DOI: 10.1021/acs.jnatprod.5c01408.
  31. Xia, Jian-Kai#; Wu, Lei-Ming#; Wu, Wei-Ye; Wu, Shu-Qi; Li, Lei; Wen, Ming-Ju; Huang, Jia-Luo; Gan, Lu; Chen, Yun-Yun; Sun, Zhang-Hua; Yin, Sheng*. Strophioglanes A–E and (±)-trigoxyphin K, ent-cleistanthane diterpenoids from Strophioblachia glandulosa var. cordifolia. Journal of Natural Products 2026, 89 (4), 1216–1225. DOI: 10.1021/acs.jnatprod.6c00053.
  32. Huang, Dong#; Liao, Yi-Ling#; Chen, Jia-Qian; Yuan, Fang-Yu; Wu, Shu-Qi; Huang, Jia-Luo; Yuan, Tao; Chen, Xin; Sun, Zhang-Hua; Tang, Gui-Hua; Gan, Lu*; Yin, Sheng*. Wikstdaphnoids A–I, daphnane diterpenoid orthoesters from Wikstroemia chamaedaphne with anti-liver fibrosis activity. Journal of Natural Products 2025, 88 (7), 1781–1790. DOI: 10.1021/acs.jnatprod.5c00536.
  33. Wen, Ming-Ju#; Wu, Leiming#; Fu, Yi-Fan; Huang, Dong; Yuan, Fang-Yu; Wu, Feng; Xia, Jian-Kai; Wu, Wei-Ye; Yuan, Tao; Huang, Jia-Luo; Tang, Gui-Hua; Yin, Sheng*. Total synthesis and biological evaluation of moralbaflavone D. Journal of Natural Products 2025, 88 (9), 2233–2238. DOI: 10.1021/acs.jnatprod.5c00729.
  34. Wu, Shu-Qi#; Zhu, Xinying#; Yuan, Tao; Yuan, Fang-Yu; Zhou, Shiyou; Huang, Dong; Wang, Ying; Tang, Gui-Hua; Huang, Zhi-Shu; Chen, Xin; Yin, Sheng*. Discovery of ingenane diterpenoids from Euphorbia hylonoma as antiadipogenic agents. Journal of Natural Products 2023, 86 (12), 2691-2702. DOI: 10.1021/acs.jnatprod.3c00822.
  35. Li, Wei#; Gan, Lu#; Yuan, Fang-Yu; Sang, Jun; Huang, Dong; Yin, Ai-Ping; Pu, Rong; Tang, Gui-Hua; Guo, Dean*; Yin, Sheng*. Biscroyunoid A, an anti-hepatic fibrotic 19-nor-clerodane diterpenoid dimer with a C-16–C-12′ linkage from Croton yunnanensis. Journal of Natural Products 2023, 86 (2), 434-439. DOI: 10.1021/acs.jnatprod.2c01054.
  36. Wang, Rong; Fan, Run-Zhu; Ni, Fu-Qiang; Sang, Jun; Xie, Xing-Lin; Luo, Si-Yuan; Tang, Gui-Hua*; Yin, Sheng*. 19-nor-, 20-nor-, and tetranor-Halimane-type furanoditerpenoids from Croton crassifolius. Journal of Natural Products 2020, 83 (2), 255-267. DOI: 10.1021/acs.jnatprod.9b00634.
  37. Li, Wei; Tang, Ya-Qi; Chen, Shi-Xin; Tang, Gui-Hua; Gan, Li-She; Li, Chan; Rao, Yong; Huang, Zhi-Shu; Yin, Sheng*. Euphorhelipanes A and B, triglyceride-lowering euphorbia diterpenoids with a bicyclo[4.3.0]nonane core from Euphorbia helioscopia. Journal of Natural Products 2019, 82 (2), 412-416. DOI: 10.1021/acs.jnatprod.8b00780.
  38. Tang, Ya-Qi; Li, Yi-Qiu; Xie, Yi-Bo; Zhang, Jun-Sheng; Li, Wei; Lou, Lan-Lan; Zhang, Ge; Yin, Sheng*. Evodialones A and B: Polyprenylated acylcyclopentanone racemates with a 3-ethyl-1,1-diisopentyl-4-methylcyclopentane skeleton from Evodia lepta. Journal of Natural Products 2018, 81 (6), 1483-1487. DOI: 10.1021/acs.jnatprod.7b00993.
  39. Wu, Wei-Ye#; Wu, Lei-Ming#; Xu, Xin-Xiang; Huang, Jia-Luo; Gan, Lu; Sun, Zhang-Hua*; Huang, Dong; Yin, Sheng*. (±)-Salviakianes A–L, twelve pairs of previously undescribed abietane diterpenoid enantiomers with anti-inflammatory activity from Salvia kiangsiensis. Journal of Organic Chemistry 2026, 91 (18), 6381–6391. DOI: 10.1021/acs.joc.6c00178.
  40. Hu, Rong; Huang, Jia-Luo; Yuan, Fang-Yu; Wei, Xun; Zou, Ming-Feng; Tang, Gui-Hua; Li, Wei*; Yin, Sheng*. Crotonianoids A–C, three unusual tigliane diterpenoids from the seeds of Croton tiglium and their anti-prostate cancer activity. Journal of Organic Chemistry 2022, 87 (14), 9301–9306. DOI: 10.1021/acs.joc.2c01024.
  41. Yuan, Fang-Yu#; Xu, Fan#; Fan, Run-Zhu; Li, Wei; Huang, Dong; Tang, Gui-Hua; Yuan, Tao; Gan, Li-She*; Yin, Sheng*. Structural elucidation of three 9,11-seco tetracyclic triterpenoids enables the structural revision of euphorol J.  Journal of Organic Chemistry 2021, 86 (11), 7588–7593. DOI: 10.1021/acs.joc.1c00631.
  42. Wu, Shu-Qi#; Wu, Lei-Ming#; Yuan, Fang-Yu; Huang, Dong; Yuan, Tao; Chen, Xin; Sun, Zhang-Hua; Tang, Gui-Hua; Huang, Jia-Luo*; Yin, Sheng*. Daphnane diterpenoids for cancer therapy by suppressing ATR-mediated DNA damage response pathway. Bioorganic Chemistry 2025, 164, 108820. DOI: https://doi.org/10.1016/j.bioorg.2025.108820.
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获奖情况

2011年 《上海市自然科学一等奖》 岳建民 杨升平 丁健 张传瑞 尹胜

2009年 《中国科学院优秀博士论文提名奖》 尹胜

2008年 《中科院院长特别奖》  尹胜

其他

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