黄家洛

简介

黄家洛，博士，副教授，硕士生导师。2025年11月入职中山大学药学院。2022年博士毕业于中山大学药学院，主要从事天然药物化学、天然产物活性成分作用靶点及药理机制研究。以活性筛选为导向从天然产物中发现抗肿瘤、抗炎等活性小分子化合物，并进行靶点确证和深入药理分子机制探索，致力于发现和确证可药性治疗新靶点，结合成药性优化策略，研发具有良好开发前景的先导分子。代表性研究成果以第一作者或通讯作者（含共同）发表于Nat. Chem. Biol., J. Am. Chem. Soc., Acta Pharm. Sin. B, Phytother. Res., J. Org. Chem., J. Nat. Prod.等领域内权威期刊。先后主持国家自然科学基金青年基金，中国博士后科学基金面上项目，中山大学青年教师培育项目等课题。

教育及工作经历

2013.09 - 2017.06，西北农林科技大学，植物科学与技术，学士

2017.09 - 2022.06，中山大学，生药学，博士（导师：尹胜教授）

2022.08 - 2024.08，中山大学，药物化学，博士后

2024.08 - 2025.11，中山大学，天然药物化学，特聘副研究员

2025.11 - 至今，中山大学，药学院，副教授

科研项目

国家自然科学基金青年科学基金项目，82304322，2024.01 - 2026.12，主持

中国博士后科学基金面上资助，2023M734063，2023.10 - 2024.08，主持

中山大学青年教师培育项目，24qnpy185，2024.01 - 2024.12，主持

代表性研究成果（*通讯作者）

1. Huang, J. L.#, Wu, L. M.#, Wu, S. Q., Yuan, F. Y., Weng, H. Z., Huang, D., Gan, L., Chen, S. B., Tang, G. H., & Yin, S*. (2025). A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy. Nature chemical biology, 10.1038/s41589-025-02040-w. Advance online publication. https://doi.org/10.1038/s41589-025-02040-w.

2. Huang, J. L.#, Yan, X. L.#, Li, W., Fan, R. Z., Li, S., Chen, J., Zhang, Z., Sang, J., Gan, L., Tang, G. H., Chen, H., Wang, J.*, & Yin, S*. (2022). Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. Journal of the American Chemical Society, 144(38), 17522–17532. https://doi.org/10.1021/jacs.2c06449.

3. Huang, J. L.#, Yan, X. L.#, Huang, D., Gan, L., Gao, H., Fan, R. Z., Li, S., Yuan, F. Y., Zhu, X., Tang, G. H., Chen, H. W., Wang, J.*, & Yin, S*. (2023). Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer. Acta pharmaceutica Sinica. B, 13(12), 4934–4944. https://doi.org/10.1016/j.apsb.2023.07.017.

4. Huang, J. L.#, Fan, R. Z.#, Zou, Y. H., Zhang, L., Yin, S., & Tang, G. H*. (2021). Salviplenoid A from Salvia plebeia attenuates acute lung inflammation via modulating NF-κB and Nrf2 signaling pathways. Phytotherapy research, 35(3), 1559–1571. https://doi.org/10.1002/ptr.6922.

5. Lu, Q. R., Li, L., Cui, Q. Y., Liao, Q., Malik, N., Wu, L. M., Liao, Y. L., Wu, S. Q., Yuan, F. Y., Yin, S., Huang, J. L.*, & Tang, G. H*. (2025). Sclerotiorin-Type Azaphilones Isolated from a Marine-Derived Fungus Microsphaeropsis arundinis P1B. Journal of natural products, 88(4), 1075–1084. https://doi.org/10.1021/acs.jnatprod.5c00169.

6. Wu, S. Q.#, Wu, L. M.#, Yuan, F. Y., Huang, D., Yuan, T., Chen, X., Sun, Z. H., Tang, G. H., Huang, J. L.*, & Yin, S*. (2025). Daphnane diterpenoids for cancer therapy by suppressing ATR-mediated DNA damage response pathway. Bioorganic chemistry, 164, 108820. https://doi.org/10.1016/j.bioorg.2025.108820.

7. Xia, J. K.#, Wu, L. M.#, Wu, W. Y., Huang, D., Yuan, F. Y., Li, L., Wu, S. Q., Zhang, Y. J., Yuan, T., Chen, X., Tang, G. H., Huang, J. L.*, & Yin, S*. (2025). Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.04,13]tridecane core from Strophioblachia glandulosa var. cordifolia. Natural products and bioprospecting, 15(1), 65. https://doi.org/10.1007/s13659-025-00548-1.

8. Hu, R.#, Huang, J. L.#, Yuan, F. Y., Wei, X., Zou, M. F., Tang, G. H., Li, W.*, & Yin, S*. (2022). Crotonianoids A-C, Three Unusual Tigliane Diterpenoids from the Seeds of Croton tiglium and Their Anti-Prostate Cancer Activity. The Journal of organic chemistry, 87(14), 9301–9306. https://doi.org/10.1021/acs.joc.2c01024.