陈硕斌

基本介绍：

陈硕斌，男，博士，教授，博士生导师。

科研情况：主持包括国家自然科学基金项目面上与青年项目等多项科研项目，入选国家级青年人才项目、广东省自然科学杰出青年基金、广州市科技计划项目珠江科技新星专题等。发表高水平论文50多篇，其中近五年以一作/通讯作者身份在Chem、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Sci.、J. Med. Chem.、Nucleic Acid Res.等国际权威期刊上发表高水平论文十数篇，获授权过中国/国际(PCT)专利10余项。

教学情况：参与本科一流课程《生物化学》、《生物化学与基础分子生物学实验》的建设与教学；参与研究生课程《生物有机化学》、《计算模拟在药学研究中的应用》等教学。

2026年拟招收专业型硕士1名，分子设计与合成方向优先，欢迎邮件联系，chenshb8@mail.sysu.edu.cn

教育与工作经历：

2007.09-2011.06 中山大学药学院，药学专业，获学士学位

2011.09-2016.06 中山大学药学院，药物化学专业，获博士学位

2016.07-2019.04 中山大学药学院，副研究员

2019.05-2025.12 中山大学药学院，副教授

2026.01-至今        中山大学药学院，教授

近五年主持省部级科研项目：

1. 国家自然科学基金—面上项目（2024年）：WRN解旋酶特异性变构抑制剂的发现及其在“化学合成致死”上的作用机制研究；

2. 国家自然科学基金—面上项目（2020年）：靶向G-四链体解旋酶DHX36新型c-MYC转录抑制剂的发现及其作用机制研究；

3. 广东省自然科学基金—杰出青年项目（2019年）：以RecQ家族G-四链体解旋酶为新靶点的药物化学研究；

4. 国家自然科学基金—青年项目（2018年）：基于癌基因NRAS 翻译调控的抗黑色素瘤先导化合物发现及作用机制研究；

5. 广州市科技计划项目珠江科技新星专题（2019年）：新型癌基因NRAS 翻译抑制剂的快速筛选与抗癌活性研究；

近五年部分代表性论著（中科院1区）：

◆ Tang, G.-X.#; Yan, J.-T.#; Li, M.-L.#; Zhou, C.; Wang, J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H*. Illuminating Mitochondrial RNA G-Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS. Adv. Sci. 2026, n/a (n/a), e23462.
◆ Jian, W.#; Yang-Yi, R.#; Ye-Ying, H.; Zhi-Fan, Q.; Gui-Xue, T.; Zhi-Shu, H.; Shuo-Bin, C.*; Lin, H.*; Jia-Heng, T.* Unlocking the potential of diarylmethane dyes for living systems. Chem 2026. DOI: 10.1016/j.chempr.2025.102883.
◆ Cai, J.-H.#; Shi, Y.-H.#; Yang, D.-Y.; Huang, W.-Y.; Liu, Y.; Zhong, L.-T.; Zhang, J.-J.; Gong, Z.; Lu, Y.-Y.; Lin, J.-H.; et al. An Orally Available Telomeric G-Quadruplex Ligand Induces Telomere Crisis and Dual DNA/RNA-Sensing Innate Immunity for Cancer Therapy. J. Med. Chem. 2026. DOI: 10.1021/acs.jmedchem.5c03148.

◆Zhang, K.#;  Nie, Q.#;  Li, M.#;  Chen, X.;  Zhong, L.;  Dai, T.;  Guo, X.;  Zhao, H.;  Lau, T. C.-K.;  Wang, H.;  Chen, S.-B.*; Kwok, C. K.*, RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. Nucleic acids Res.2025, 53 (3), doi:10.1093/nar/gkaf039. 

◆ Ning, K.#;  Tang, X.;  Li, Z.;  Zhong, L.;  Zhou, Y.;  Wang, J.;  Huang, W.;  Zhang, H.;  Ke, J.;  Luan, T.*;  Chen, S.-B.*; Zhai, J.*, Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe. Adv. Sci. 2025, n/a (n/a), 2413368.

◆ Lin, X.; Huang, Y.; Huang, J.; Yuan, H.; Luo, Y.; Lu, Z.; Ao, Y.; Huang, J.; Chen, S.*; Miao, Z.*; Huang, L.* From Theophylline to Adenine or preQ1: Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis. Angew Chem Int Ed 2025, 64 (22). 

◆ Hu, Y.-T.; Luo, J.-C.; Xu, S.-M.; Jiang, Z.; Lin, Y.-W.; Li, Y.-X.; Tan, J.-H.; Chen, S.-B.; Huang, Z.-S. Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity. Journal of medicinal chemistry 2025, 68 (16), 17364–17377. DOI: 10.1021/acs.jmedchem.5c00895. 

◆ Jiang, Z.;  Hu, Y.-T.;  Guo, S.-Y.;  Li, Y.-X.;  Zhao, D.-D.;  Wei, L.-Y.;  Lin, Y.-W.;  Xu, S.-M.;  Huang, S.-L.;  Li, Q.;  Tan, J.-H.;  Rao, Y.;  Chen, S.-B.*; Huang, Z.-S.*, Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group. J. Med. Chem. 2024, 67 (14), 12439-12458.

◆ Li, M.-L.#;  Dai, L.-T.;  Gao, Z.-Y.;  Yan, J.-T.;  Xu, S.-M.;  Tan, J.-H.;  Huang, Z.-S.;  Chen, S.-B.*; Chen, X.-C.*, Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes. J. Med. Chem. 2024, 67 (3), 1961-1981.

◆ Cai, J.-H.#;  Yang, D.-Y.#;  Zhang, J.-J.;  Tan, J.-H.;  Huang, Z.-S.*; Chen, S.-B.*, Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry. Bioorg. Chem. 2024, 144, 107173.

◆ Xu, Y.-H.#;  Hu, Y.-T.#;  Xu, S.-M.;  Song, B.-B.;  Yuan, H.;  Zhao, D.-D.;  Guo, S.-Y.;  Jiang, Z.;  Wei, L.-Y.;  Rao, Y.;  Tan, J.-H.;  Huang, S.-L.;  Li, Q.-J.;  Chen, S.-B.*; Huang, Z.-S.*, Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer. J. Med. Chem. 2023, 66 (11), 7387-7404.

◆ Chen, X.-C.#;  Tang, G.-X.#;  Dai, J.#;  Dai, L.-T.;  Wu, T.-Y.;  Li, W.-W.;  Ou, T.-M.;  Huang, Z.-S.;  Tan, J.-H.*; Chen, S.-B.*, Discovery of Clinically Used Octenidine as NRAS Repressor That Effectively Inhibits NRAS-Mutant Melanoma. J. Med. Chem. 2023, 66 (7), 5171-5184.

◆ Yuan, J.-H.#; Tu, J.-L.; Liu, G.-C.; Chen, X.-C.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.*, Visualization of ligand-induced c-MYC duplex–quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells. Nucleic Acids Res .2022, 50(8), 4246-4257.

◆ Li, M.-L.#;  Yuan, J.-M.#;  Yuan, H.;  Wu, B.-H.;  Huang, S.-L.;  Li, Q.-J.;  Ou, T.-M.;  Wang, H.-G.;  Tan, J.-H.;  Li, D.;  Chen, S.-B.*; Huang, Z.-S.*, Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex. J. Med. Chem. 2022, 65, 12675.

◆ Jiang, X.-C.#;  Tu, F.-H.#;  Wei, L.-Y.;  Wang, B.-Z.;  Yuan, H.;  Yuan, J.-M.;  Rao, Y.;  Huang, S.-L.;  Li, Q.-J.;  Ou, T.-M.;  Wang, H.-G.;  Tan, J.-H.;  Chen, S.-B.*; Huang, Z.-S.*, Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. J. Med. Chem. 2022, 65, 12346.

◆ Yu, Z.-Y.#; Luo, W.-H.#; Wang, J.-E.; Diao, H.-J.; Wu, T.-Y.; Zeng, S.-T.; Chen, X.-C.; Huang, Z.-S.; Tan, J.-H.; Chen, S.-B.*, Dual-color imaging of DNA and RNA simultaneously with an aggregation/monomer-based deep-red fluorescent probe. Sens. Actuators. B Chem. 2022, 361, 131730.

◆ Chen, X.-C.#; Tang, G.-X.; Luo, W.-H.; Shao, W.; Dai, J.; Zeng, S.-T.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.*, Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. J. Am. Chem. Soc. 2021, 143 (49), 20779-20791.