wangxiansong

王显嵩

副教授

研究领域：主要从事基于全基因组及进化角度的肿瘤进化规律挖掘工作

联系邮箱： wangxiansong@mail.sysu.edu.cn

个人简介：

副教授，硕士生导师，生物信息学专业，2021年获得香港中文大学博士学位。于2023年11月加入中山大学。主要从事基于全基因组与多组学数据整合的肿瘤进化规律发现。以第一作者（含共同）先后发表了 11篇文章，包括Annals of Oncology，Cancer Research，Gastroenterology等高水平期刊论文。

 

招生信息

2027年拟招收专业学位硕士研究生 1 名。

 

申请建议

  1. 建议申请者尝试提前学习 R 语言或 Python 的基础知识；
  2. 如入学前暂无生物信息学相关背景，硕士期间需补充生物统计、生物信息学、机器学习等专业知识。

 

欢迎对肿瘤基因组学与多组学数据分析感兴趣的同学联系。

 

在研项目：

 

国自然面上项目：三维基因组结构的突变耐受机制及其应用研究， 2027.01-2030.12， 项目负责人

 

研究成果:

  1. Wang X^, Li X^, Zhang L^, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK. "Oncogenes expand during evolution to withstand somatic amplification." Annals of Oncology 29, no. 11 (2018): 2254-2260.[IF = 80.04, Q1]
  2. Xiansong Wang^; Frankie T.F. Cheng^; Thomas Y.T. Lam^; Yingzhi Liu; Dan Huang; Xiaodong Liu; Huarong Chen; Lin Zhang; Yusuf Ali; Maggie H.T. Wang; Jun Yu; Tony Gin; Matthew T.V. Chan; William K.K. Wu; Sunny H. Wong. "Stress Hyperglycemia Is Associated With an Increased Risk of Subsequent Development of Diabetes Among Bacteremic and Nonbacteremic Patients." Diabetes Care 45, no. 6 (2022): 1438-1444..[IF=22.6, Q1]
  3. Wang, Xiansong^, Wei Hu^, Xiangchun Li, Dan Huang, Qing Li, Hung Chan, Judeng Zeng, Chuan Xie, Huarong Chen, Xiaodong Liu, Tony Gin, Maggie Haitian Wang, Alfred Sze Lok Cheng, Wei Kang, Ka-Fai To, Dariusz Plewczynski, Qingpeng Zhang, Xiaoting Chen, Danny Cheuk Wing Chan, Ho Ko, Sunny Hei Wong, Jun Yu, Matthew Tak Vai Chan, Lin Zhang, William Ka Kei Wu. "Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution" Cancer Research 82, no. 8 (2022): 1482-1491.[IF=22.6, Q1]
  4. Huang, Ziheng, Lin Zhang, Huarong Chen, Xiaodong Liu, Likai Tan, Dan Huang, Yingzhi Liu, Yushan Wang, Xinyi Zhang, Alfred Sze Lok Cheng, Maggie Haitian Wang, Wei Kang, Ka Fai To, Jun Yu, Ho Ko, Le Yu, Sunny H Wong, Tony Gin, Matthew Tak Vai Chan^, Xiansong Wang^ and William Ka Kei Wu^. “Tumor Suppressor Genes with Segmental Duplications are Prone to Somatic Deletions and Structural Variations.” Cancer research (2025): n. pag.[IF=22.6, Q1，封面文章]
  5. Zhou, Jiawang, Jia-xin He, Yunqing Lu, Cheng Yi, Xing Chang, Lijun Tao, Ke Zhong, Haisheng Zhang, Hongxin Niu, Xiansong Wang^, Zhuojia Chen^ and Hongsheng Wang^. “Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma.” Research 9 (2026): n. pag.[IF=12.9, Q1]
  6. Huang, Dan^, Xiaoting Zhang^, Xiansong Wang^, Ziheng Huang, Judeng Zeng, Xiaodong Liu, Likai Tan, Lin Zhang, Zhenxing Guo, Tony Gin, Jun Yu, Kwok Ming Ho, Matthew T. V. Chan, Huarong Chen and William Ka Kei Wu. “Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription.” Oncogene 45 17 (2026): 1600-1612 .[IF=9.1, Q1]
  7. Kwong, Thomas NY^, Xiansong Wang^, Geicho Nakatsu, Tai Cheong Chow, Timothy Tipoe, Rudin ZW Dai, Kelvin KK Tsoi, Martin C.S.Wong, GaryTse, Matthew T.V.Chan, Francis K.L.Chan, Siew C.Ng, Justin C.Y.Wu, William K.K.Wu, JunYu, Joseph J.Y.Sung, Sunny H.Wong. "Association between bacteremia from specific microbes and subsequent diagnosis of colorectal cancer." Gastroenterology 155, no. 2 (2018): 383-390..[IF=29.7, Q1]
  8. Zhou, Jiandong^, Xiansong Wang^, Sharen Lee^, William Ka Kei Wu, Bernard Man Yung Cheung, Qingpeng Zhang, and Gary Tse. "Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study." Gut 70, no. 10 (2021): 2012-2013. [IF=24.6, Q1]
  9. Dan Huang^, Xiansong Wang^, Yingzhi Liu, Ziheng Huang, Xiaoxu Hu, Wei Hu, Qing Li, Hung Chan, Yidan Zou, Idy H T Ho, Yan Wang, Alfred S L Cheng, Wei Kang, Ka F To, Maggie H T Wang, Sunny H Wong, Jun Yu, Tony Gin, Qingpeng Zhang, Zheng Li, Jianxiong Shen, Lin Zhang, Matthew T V Chan, Xiaodong Liu, William K K Wu "Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance." Briefings in Bioinformatics 22, no. 5 (2021): bbab040.[IF=7.3, Q1]
  10. Wu, William KK^, Xiangchun Li^, Xiansong Wang^, Rudin ZW Dai, Alfred SL Cheng, Maggie HT Wang, Thomas Kwong et, Tai C. Chow, Jun Yu, Matthew T.V. Chan, Sunny H. Wong. "Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification." Molecular biology and evolution 34, no. 4 (2017): 903-907.[IF=6.4, Q1]
  11. Dan Huang^, Xiansong Wang^, Ziheng Huang, Yingzhi Liu, Xiaodong Liu, Tony Gin, Sunny Hei Wong, Jun Yu, Lin Zhang, Matthew Tak Vai Chan, Huarong Chen & William Ka Kei Wu "3′ untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance." Oncogene (2022): 1-11..[IF=9.1, Q1]

 

专利：

发明创造名称：一种推断基因起源时间的方法、装置和存储介质，发表

 

主要负责课程：

《临床大数据与人工智能》