联系方式

办公电话:020-39943470

电子邮箱:bihchang@mail.sysu.edu.cn

办公地址:广州市大学城外环东路132号 中山大学药学院,邮编:510006

 

简单介绍

毕惠嫦 博士,中山大学药学院教授/博导、副院长,美国匹兹堡大学药学院兼职副教授。2007年毕业于中山大学获博士学位并留任药学院,2011年至2012年于美国国立卫生研究院、国家癌症研究所(NCI/NIH)作博士后/访问学者。研究方向为代谢调控,专注于核受体/代谢酶/转运蛋白影响下内/外源物代谢与调控对疾病发生发展转归及合理用药的研究。目前目前担任中国药理学会药物代谢与药动学专业委员会青委会主任委员、中国药理学会临床药理学专业委员会副秘书长/常委、广东省药理学会常务理事、广东省药理学会治疗药物监测专业委员会副主任委员、药物筛选与评价专业委员会常务委员、药物毒理专业委员会委员、广东省执业药师协会第三届理事会理事。担任SCI期刊《Journal of Biochemical and Molecular Toxicology》、《Acta Pharmaceutica Sinica B》、《Chinese Medicine》、《Chinese Journal of Natural Medicines》编委,《药学学报》、《Journal of Pharmaceutical Analysis》青年编委、《中国生化药物杂志》编委。同时是中国药理学学会会员、国际外源物代谢研究学会(ISSX)会员、国际代谢组学学会会员。并担任20多种国际学术期刊的特邀审稿人。主持国家自然科学基金、国家重点研发计划等国家及省部级科研基金近20项。已出版专著2部(主编、副主编),参编专著5部,在国内外期刊发表研究论文130多篇,其中SCI收录90多篇,以通讯作者或第一作者在Hepatology, Cell Death & Differentiation, Cell Death & Disease, British Journal of Pharmacology, Carcinogenesis, Drug Metabolism and Disposition, Toxico Sci等发表SCI论文50多篇。申请专利多项。获2014年中国药理学会-SERVIER青年药理学工作者奖、2015年国家自然科学优秀青年科学基金、2018年亚太药物代谢青年学者奖(2018 Asia Pacific New Investigator Award)。

 

研究方向

代谢组学、代谢调控与疾病及临床合理用药。

 

教育经历

1993.09 ~ 1997.06:中国药科大学,获英语药学学士学位
2002.09 ~ 2007.06:中山大学药学院,获药理学博士学位

 

工作经历

2007.07 ~ 至今:中山大学药学院药物代谢与药代动力学实验室、中山大学临床药理研究所
2011.10 ~ 2012.11:美国国立卫生研究院、国家癌症研究所(NCI/NIH)

 

科研项目

  1. 国家重点研发计划政府间国际科技创新合作重点专项,2018.07~2022.06,负责。

  2. 国家自然科学基金优青项目,2016.01~2018.12,负责。

  3. 国家自然科学基金面上项目,2016.01~2019.12,负责。

  4. 国家自然科学基金面上项目,2014.01~2017.12,负责。

  5. 国家自然科学基金青年项目,2011.01~2013.12,负责。

  6. 广东省自然科学基金重点项目,2017.08~2020.08,负责。

  7. 广东省自然科学基金面上项目,2015.08~2018.08,负责。

  8. 广州市科技计划项目(健康医疗协同创新重大专项),2014.06~2017.06,分题负责。

  9. 广州市科技计划项目(科技惠民专项),2014.06~2017.06,负责。

  10. 广东省新药设计与评价重点实验室开放基金,2014.01~2014.11,负责。

  11. 高校基本科研业务费“中山大学青年教师培育项目”,2013.11~2016.11,负责。

  12. 国家科技支撑计划课题(国家中医药管理局), 2012.01~2013.12,分题负责。

  13. 高等学校博士学科点专项科研基金(新教师基金课题),2011.01~2013.12,负责。

  14. 国家重点基础研究发展计划(973计划),分题负责。

  15. 澳门大学-澳门科学技术发展局联合基金,2009.01~2010.12,联席负责。

  16. 广州市科技计划项目(科技支撑引导项目),2011.09~2013.09,负责。

  17. 广东省医学科研基金,2009.01~2010.12,负责。

  18. 广东省中医药局科研基金,2009.01~2010.12,负责。

 

论著专利

出版专著

1.《药物临床试验标准操作规程实用指南》.广东科技出版社. 2004.(副主编)

2.案例版《临床药物代谢动力学》,科学出版社,2010.(参编2万字)

3.普通高等教育“十一五”国家级规划教材《临床药理学》,高等教育出版社,2010.(参编2万字)

4.《英汉药物词典》. 商务出版社. 2010年出版. (第一编者,参编5万字)

5.《量体裁药不是梦——从基因到个体化用药》. 广东科技出版社. 2011.(主编)

6.Dextromethorphan: Pharmacology, Clinical Uses and Health Effects. Chapter 2--Pharmacogenetics of dextromethorphan: a systematic review. Zhang Yu, Huang Min, Bi Huichang*. ISBN: 978-1-63484-016-3. Nova Science Publisher, Pub. Date: November 2015. (Corresponding author for Chapter 2, 9000 words).

7.普通高等教育“十一五”国家级规划教材案例版《临床药物代谢动力学》,科学出版社,2016,第三版.(参编2万字)

 

近3年发表的部分通讯及一作论文

  1. Jiang Yiming, Feng Dechun, Ma Xiaochao, Fan Shicheng, Gao Yue, Fu Kaili, Wang Ying, Sun Jiahong, Yao Xinpeng, Liu Conghui, Zhang Huizhen, Xu Leqian, Liu Aiming, Gonzalez J Frank, Yang Yingzi, Gao Bin, Huang Min, Bi Huichang*. Pregnane X receptor regulates liver size and liver cell fate via yes-associated protein activation. Hepatology, 2018 May 30, accepted.

  2. Wang Yongtao, Chen Yixin, Guan Lihuan, Zhang Huizheng, Huang Yaoyao, Johnson H Caroline, Wu Zeming, Gonzalez J Frank, Yu Aiming, Huang Peng, Wang Ying, Yang Shouhui, Chen Pan, Fan Xiaomei, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death and Differentiation. 2018 Mar; 25(4):733-746.

  3. Sun Jiahong#, Wen Yajie#, Zhou Yanying#, Jiang Yiming, Chen Yixin, Zhang Huizheng, Guan Lihuan, Yao Xinpeng, Huang Min*, Bi Huichang*. P53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression. Cell Death and Disease. 2018 May, 9(5): 536-547.

  4. Li Jingjie#, Guan Lihuan#, Zhang Huizhen, Gao Yue, Sun Jiahong, Gong Xiao, Li Dongshun, Chen Pan, Liao Xiaoyan, Huang Min, Bi Huichang*. Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages. Reproductive Biology and Endocrinology. 2018 April, 16(1): 42-51.

  5. Li Jingjie#, Gao Yue#, Guan Lihuan, Zhang Huizhen, Sun Jiahong, Gong Xiao, Li Dongshun, Chen Pan, Ma Zheng, Liang Xiaoyan, Huang Min, Bi Huichang*Discovery of phosphatidic acid, phosphatidylcholine, and phosphatidylserine as biomarkers for early diagnosis of endometriosis. Frontiers in Physiology, 2018 Jan. 9(14): doi: 10.3389/fphys.2018.00014.

  6. Li Xi#, Sun Jiahong#, Fan Xiaomei, Guan Lihuan; Li Dongshun, Zhou Yawen, Zeng Xuezhen,  Chen Yixin, Zhang Huizhen, Xu Leqian, Jiang Fulin, Huang Min, Bi Huichang*. Schisandrol B promotes liver regeneration after partial hepatectomy in mice. European Journal of Pharmacology, 2018 Jan 5; 818:96-102.

  7. Chen Pan#, Li Dongshun#, Chen Yixin#, Sun Jiahong, Fu Kaili, Guan Lihuan, Zhang Huizhen, Jiang Yiming, Li Xi, Zeng Xuezhen, Chen Xiao, Huang Min, Bi Huichang*. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. British Journal of Pharmacology. 2017 Dec; 174(23):4345-4361.

  8. Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M, Bi Huichang*Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta Pharm Sin B. 2017 Sep; 7(5):583-592.

  9. Zhang Huizhen, Gao Yue, Sun Jiahong, Fan Shicheng, Yao Xinpeng, Ran Xiaorong, Zheng Chuanqi, Huang Min, Bi Huichang*. Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells. Analytical and Bioanalytical Chemistry, 2017; 409(22): 5349-5258.

  10. Chen Yixin, Wang Yongtao, Huang Yaoyao, Zeng Hang, Hu Bingfang, Guan Lihuan, Zhang Huizhen, Yu Aiming, Johnson H Caroline, Gonzalez J Frank, Huang Min, Bi Huichang*. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis, 2017; 38(4):474-483.

  11. Zeng Hang#, Jiang Yiming#, Chen Pan, Fan Xiaomei, Li Dongshu, Liu Aiming, Ma Xiaochao, Xie Wen, Liu Peiqing, Gonzalez Frank J, Huang Min, Bi HuichangSchisandrol B protects against cholestatic liver injury through pregnane X receptor. British Journal of Pharmacology. 2017; 174(8):672-688.

  12. Zhang Huizhen#, Jiang Yiming#, Wu Jingjing, Zheng Chuanqi, Ran Xiaorong, Li Dongshun, Huang Min, Bi Huichang*. Metabolic mapping of Schisandra Sphenanthera extract and its active lignans using ultrahigh-performance liquid chromatography coupled with electronspray ionization high-resolution mass spectrometry based metabolomics approach. Journal of Separation Science, 2017; 40(2):574-586.

  13. Li Yuhua#, Huang Ling#, Sun Jiahong, Wei Xiaohua, Wen Jinhua, Zhong Guoping, Huang Min, Bi Huichang*. Mulberroside A suppresses PXR-mediated transactivationand gene expression of P-gp in LS174T cells. Journal of Biochemical and Molecular Toxicology. 2017 May;31(5). doi: 10.1002/jbt.21884.

  14. Xu Chenshu, Huang Min, Bi Huichang*. PXR- and CAR-mediated herbal effect on human diseases. Biochim Biophys Acta - Gene Regulatory Mechanisms. 2016; 1859(9):1121-1129.

  15. Yu Tao#, Wang Yongtao#, Zhang Huizhen, Caroline H Johnson, Jiang Yiming, Li Xiangjun, Wu Zeming, Liu Tian, Kristopher W Krausz, Yu Aiming, Frank J Gonzalez, Huang Min, Bi Huichang*. Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells. Analytical and Bioanalytical Chemistry. 2016; 408(16):4267-4273.

  16. Li Xi, Fan Xiaomei, Li Dongshun, Zeng Xuezhen, Zeng Hang, Wang Yongtao, Zhou Yawen, Chen Yixin, Huang Min*, Bi Huichang*. Schisandra sphenanthera extract facilitates liver regeneration after partial hepatectomy in mice. Drug Metab Dispos. 2016; 44(5):647-652.

  17. Zeng Hang, Li Dongshun, Qin Xiaoling, Chen Pan, Tan Huasen, Zeng Xuezhen, Li Xi, Fan Xiaomei, Jiang Yiming, Zhou Yawen, Chen Yixin, Wang Ying, Huang Min*, Bi Huichang*. Hepato-protective effects of schisandra sphenanthera extract against lithocholic acid-induced cholestasis in male mice are associated with the activation of PXR pathway and promotion of liver regeneration. Drug Metab Dispos. 2016; 44(3):337-342.

  18. Jiang Yiming#, Wang Ying#, Tan Huasen, Yu Tao, Fan Xiaomei, Chen Pan, Zeng Hang, Huang Min*, Bi Huichang*. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity via the activation of NRF2/ARE pathway. Acta Pharmacologica Sinica. 2016; 37(3):382-389.

  19. Tan Huasen#, Xu Chenshu#, Zeng Hang, Wang Ying, Li Yingmei, Fan Xiaomei, Chen Pan, Jiang Yiming, Chen Xiao, Huang Min*, Bi Huichang*. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells. Journal of Pharmacological Sciences. 2016; 130(2):66-71.

  20. Chen Pan#, Li Jingjie#, Fan Xiaomei, Zeng Hang, Deng Rongrong, Li Dongshun, Huang Min, Bi Huichang*. Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism. European Journal of Pharmacology. 2015; 765:131-139.

  21. Wang Ying#, Jiang Yiming#, Fan Xiaomei, Tan Huasen, Zeng Hang, Wang Yongtao, Chen Pan, Huang Min, Bi Huichang*Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Toxicol Lett. 2015;236(2):82-89.

  22. Jiang Yiming#, Fan Xiaomei#, Wang Ying, Tan Huasen, Chen Pan, Zeng Hang, Huang Min*, Bi Huichang*Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are associated with the inhibition of CYP-mediated bioactivation. Chem Biol Interact. 2015; 231: 83-89.

  23. Jiang Yiming#, Fan Xiaomei#, Wang Ying, Chen Pan, Zeng Hang, Tan Huasen, Gonzalez J Frank, Huang Min, Bi Huichang*. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicological Sciences. 2015;143(1):107-115.

  24. Fan Xiaomei, Chen Pan, Jiang Yiming, Wang Ying, Tan Huasen, Zeng Hang, Wang Yongtao, Qu Aijuan, Gonzalez Frank, Huang Min, Bi Huichang*. Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine. Drug Metab Dispos. 2015;43(3):317-324.

  25. Yu Tao#, Wang Yongtao#, Chen Pan, Li Yuhua, Chen Yixin, Zeng Hang, Yu Aiming, Huang Min, Bi Huichang*. Effects of Nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress. Cellular Physiology and Biochemistry. 2015;35(2):710-721.

  26. Fan Xiaomei#, Jiang Yiming#, Wang Ying, Tan Huasen, Zeng Hang, Wang Yongtao, Chen Pan, Qu Aijuan, Gonzalez Frank J., Huang Min, Bi Huichang*. Wuzhi tablet (Schisandra sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos. 2014;42(12):1982-1990.

  27. Wang Ying, Jiang Yiming, Wang Yongtao, Kang Junwei, Yu Tao, Zhao Haiyu, Bian Baolin, Huang Min, Bi Huichang*. Inhibiton of cytochrome P450 isoenzymes and P-gp activity by multiple extracts of Huang-Lian-Jie-Du Decoction. Journal of Ethnopharmacology. 2014;156:175-181.

  28. Deng Rongrong#, Xu Chenshu#, Chen Xiao*, Chen Pan, Wang Yongtao, Zhou Xunian, Jin Jing, Niu Lu, Ying Mengjia, Huang Min, Bi Huichang*. Resveratrol suppresses the inducible expression of CYP3A4 through the Pregnane X Receptor. Journal of Pharmacological Sciences. 2014;126(2):146-154.

  29. Bi Huichang, Pan Yuzhuo, Krausz W Kristopher, Li Fei, Johnson H Caroline, Jiang Changtao, Gonzalez J Frank, Yu Aiming*. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291 altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis. 2014, 35(10):2264-2272.

  30. Fan Xiaomei, Chen Pan, Tan Huasen, Zeng Hang, Jiang Yiming, Wang Ying, Wang Yongtao, Hou Xiangyu, Bi Huichang*, Huang Min*. Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration. Drug Metab Dispos. 2014;42(9):1532-1539.

  31. Cai Yike#, Xu Chenshu#, Chen Peiyi, Hu Junqing, Hu Rong, Huang Min, Bi Huichang*. Development, Validation, and Application of a Novel 7-Day Caco-2 Cell Culture System. Journal of Pharmacological and Toxicological Methods. 2014;70(2):175-181.

  32. Li Yuhua, Huang Ling, Zeng Xuezhen, Zhong Guoping, Ying Mengjia, Huang Min*, Bi Huichang*. Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B. Chemico-Biological Interactions. 2014;213:44-50.

  33. Pan Chen, Hang Zeng, Yongtao Wang, Xiaomei Fan, Chenshu Xu, Rongrong Deng, Xunian Zhou, Bi Huichang*, Min Huang*. Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of Nrf2 mediated up-regulation of Mrps. Drug Metab Dispos. 2014, 42(5):844-852.  

  34. Qin Xiaoling, Chen Xiao*, Zhong Guoping, Fan Xiaomei, Wang Ying, Xue Xinping, Wang Ying, Huang Min, Bi Huichang*. Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi Tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. Phytomedicine. 2014, 21(5):766-772.

  35. Qin Xiaoling, Chen Xiao, Wang Ying, Xue Xinping, Wang Ying, Li Jiali, Wang Xueding, Zhong Guoping, Wang Changxi, Yang Hui, Huang Min*, Bi Huichang*]. In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra Sphenanthera extract) on the CYP3A/P-gp mediated absorption and metabolism of tacrolimus. Drug Metab Dispos; 2014, 42(1):193-199. 

  36. Huang Ling, Wu Qian, Li Yuhua, Wang Yitao, Bi Huichang*. PXR mediated upregulation of CYP3A expression by herb compound Praeruptorin C from Peucedanum praeruptorum Dunn. Evidence-Based Complementary and Alternative Medicine. 2013;156574. doi: 10.1155/2013/156574. Epub 2013 Nov 26.    

  37. Zhou Xunian, Bi Huichang*, Jin Jing, Niu Lu, Cai Dake, Deng Rongrong, Li Yuhua, Wang Yongtao, Huang Min*. Effects of praeruptorin A and praeruptorin C, a racemate isolated from Peucedanum praeruptorum Dunn, on MRP2 through CAR pathway. Planta Med. 2013. 79(17):1641-7.  

  38. Huang Ling, Huang Min, Li Yuhua, Li Ruiming, Zeng Yu, Kuang Shaoyi, Zhang Li, Wang Yitao, Bi Huichang*. Up-regulatation of CYP3A expression through Pregnent X Receptor by Praeruptorin D Isolated from Peucedanum praeruptorum Dunn. Journal of Ethnopharmacology. 2013. 148(2):596-602.   

  39. Bi Huichang*, Krausz W Kristopher, Soumen K. Manna, Li Fei, Johnson H Caroline, Gonzalez J Frank. Optimization of harvesting, extraction and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells. Analytical and Bioanalytical Chemistry. 2013. 405(15):5279-5289.