联系方式

办公电话:

电子邮箱:wanguoh@mail.sysu.edu.cn

办公地址:广州中山大学药学院321A室

简单介绍

万国辉,博士,中山大学教授,博导,中山大学“百人计划二期”引进人才。

研究方向

  1. 非编码RNA在恶性肿瘤生物学行为中的作用及其相关候选药物的研发

  2. 肿瘤精准治疗策略探索

  3. 肿瘤免疫治疗与肿瘤耐药机制研究

 

教育经历

2009年  香港中文大学,生物化学, 博士

工作经历

2017年 中山大学,药学院,教授

教学情况

本科课程

«生物技术制药»

«微生物学与免疫学»

«药物分子生物学»(生科院)

社会/学术任职

2017年 «药学学报»AB刊,青年编委

科研项目

国家自然科学基金青年项目

中山大学青年教师重点培育项目

中山大学“百人计划二期”启动项目

论著专利

1. Niu Y., Wan A., Lin Z., Lu X. Wan G. N6-methyladenosine modification: a novel pharmacological target for anti-cancer drug development. Acta Pharmaceutica Sinica B. 2018, in press.

2. Wang Y, Wan GH, Wu YM, Wang HS, Wang HF, Zhang G, Lu LL, Li ZQ, Chan KY, Zhou Y, Cai SH, Qi YF, Du J. AP-1 confers resistance to anti-cancer therapy by activating XIAP. Oncotarget. 2018, 9(18):14124-14137.

3. Han C., Yang L., Choi H., Baddour J., Achreja A., Liu Y., Li Y., Li J., Wan G., Huang C., Zhang X., Nagrath D., Lu X. Amplification of USP13 drives ovarian cancer metabolism. Nature Communication. 2016, 7:13525

4. Liu Y., Zhang X., Han C., Wan G., HuangX., Ivan C., Jiang D., Rodriguez-Aguayo C., Lopez-Berestein G., Rao P., Maru D., Pahl A., He X., Sood A., Ellis L., Anderl J., Lu X. TP53 loss creates therapeutic vulnerability in cancer. Nature. 2015, 520(7549):697-701. 

5. Han C., Liu Y., Wan G., Choi H., Zhao L., Ivan C., He X., Sood A., Zhang X., Lu X. The RNA-binding protein DDX1 promotes primary miRNAs maturation and inhibits ovarian tumor progression. Cell Reports. (Article),2014, 8(5):1447-60. 

6. Wan G., Liu Y., Han C., Zhang X., Lu X. Noncoding RNAs in DNA Repair and Genome Integrity. Antioxidants & Redox Signaling, 2014, 20(4):655-77. 

7. Zhou Y., Wan G., Spizzo R., Ye X., Hu X., Mathur R., Lu J., Xia L., Fan F., Calin G.A., Lu X., Ellis L.M. miR-203 Induces Oxaliplatin Resistance through Negative Regulation on ATM in Colorectal Cancer Cells. Molecular Oncology, 2014, 8(1):83-92. 

8. Wan G., Hu X., Liu Y., Han C., Sood A.K., Calin G.A., Zhang X., Lu X. A novel long noncoding RNA lncRNA-JADE connects DNA damage to histone H4 acetylation. The EMBO Journal, 2013, 32(21):2833-47. 

9. Wan G., Zhang X., Langley R.R., Liu Y., Hu X., Han C., Peng G., Ellis L.M., Jones S.N., Lu X. DNA Damage-induced Nuclear Export of Precursor MicroRNAs is Regulated by the ATM-AKT Pathway. Cell Reports. (Article) 2013, 3(6):2100-12. 

10. Wan G., Mathur R., Hu X., Liu Y., Zhang X., Peng G., Lu X. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. Cellular Signalling, 2013, 25(5):1086-95. 

11. Wan G. Wang M. Decipher the mystery of long non-coding RNAs - Novel CRISPR/Cas system for genome-editing. Gene Technology. 2013, 2:103

12. Lu Z., Wan G., Guo H., Zhang X., Lu X. Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx. Cellular Signalling, 2013, 25(4):796-804. 

13. Lu X., Wan G. Therapeutic Prospects of MicroRNA in Human Cancer. Journal of Integrative Oncology, 2012, 1:e102

14. Han C., Wan G., Langley R.R., Zhang X., Lu X. Crosstalk between DNA damage and MicroRNAs. Cellular and Molecular Life Sciences, 2012, 69(17):2895-906. 

15. Wan G., Mathur R., Hu X., Zhang X., Lu X. miRNA response to DNA damage. Trends in Biochemical Sciences, 2011, 36(9):478-484. 

16. Zhang X.*, Wan G.*,Berger F.G., He X., Lu X. The ATM kinase induces microRNA biogenesis in the DNA damage response. Molecular Cell. 2011, 41(4):371-383. (*equal contribution) 

17. Zhang X., Wan G., Mlotshwa S., Vance V., Berger F.G., Chen H., Lu X. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Research. 2010, 70(18):7176-7186. 

18. Wan G., Chan K.M. A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae. Journal of Molecular Endocrinology, 2010, 45(5):301-315. 

19. Wan G., Cheuk W.K., Chan K.M. Differential regulation of zebrafishmetallothionein-II (zMT-II) gene transcription in ZFL and SJD cell lines by metal ions. Aquatic Toxicology, 2009, 91(1):33-43.

 

其他

本课题组欢迎研究员、博士后、研究助理等优秀科研人员加入,有意者请垂询wanguoh@mail.sysu.edu.cn。