联系方式

办公电话:020-39943027

电子邮箱:zhangge@mail.sysu.edu.cn

办公地址:

简单介绍

张革,女,博士,副教授,博士生导师。

研究方向

微生物与生化药学

肿瘤相关微生物学,疫苗,益生菌制剂的研究。

靶向抗肿瘤药物前体的活性及机制研究。

肿瘤分子标记及早期诊断试剂盒的研究

教育经历

2002--2005年    中山大学中山医学院 组织胚胎与解剖学博士学位

 

1997--2000年    重庆医科大学基础医学院 生物化学和分子生物学专业硕士学位。

1989--1993年    西北大学生物系 微生物学学士学位。

 

 

工作经历

2003--至今        中山大学药学院  微生物与生化制药实验室 副教授 博导

2000--2003年    中山大学分子医学中心 分子医学 助理研究员

1993--1997年    陕西省人民医院 临床微生物检验 技术员

 

 

教学情况

生物技术制药(课程负责人.)

微生物与免疫学(课程负责人)

省级教学基地中山大学药学院广州栋方股份公司教学实践基地(项目负责人2015/5 -2018/5, 20

 

科研项目

主持基金项目如下:

国家自然科学基金面上项目:耐具核梭杆菌拮抗的双歧杆菌及其重组活载体防治结直肠癌的实验研究;(81673005;2017/1-2020/12, 58万)

国家自然科学基金面上项目:具核梭杆菌在食管癌发生发展中的作用及其机制的研究。(81372573;2014/1-2017/12,70万)

国家自然科学基金面上项目:iRGD-GP肽修饰的细胞毒类抗肿瘤靶向药物的研究。(81072670;2011/1-2013/12,30万)

广东省自然科学基金项目基于菌群变化的结直肠癌早期筛查研究(No2017A0303137462018/1-2020/1210万)

广东市科技计划项目:天然冰片制备过程副产物的回收纯化及其在绿色药妆中的应用研究 (2017/1-2018/12, 50万)

广东省科技计划项目:CDC25B等自身抗体反向芯片对食管癌早期诊断的研究。(2012B031800260,2012/1-2014/12, 4万)

广东省花都区科技计划项目:基于植物多糖在绿色抗衰老化妆品中的应用研究。(HD15GY018,2015/01-2016/12,9万)

中山大学青年教师培育项目: 靶向FAPa增强DC-CIK免疫治疗效果的实验研究。(2011/1-2014/12,15万)

企业横向基金:绿色化妆品中生物功效成分的细胞学评价。(2015/3 -2018/8, 12万 )

企业横向基金:益生菌验证项目。(2015/5 -2017/5,8万)

 

 

论著专利

代表性论文:

Guo SH, Li LF, Xu BL, Li MH, Zeng QY, Xiao H, Xue Y, Wu YX, Wang YD, Liu WL*, Zhang G*. A simple and novel faecal biomarker for colorectal cancer: ratio of Fusobacterium nucleatum to probiotics populations based on their antagonistic effect. Clinical Chemistry. 2018, 64(9)doi:10.1373/clinchem. 2018.289728, IF=8.636

 

Feng XW, Lu JF, He ZT, Wang YD, Qi FF, Pi RX, Zhang G*. Mycobacterium smegmatis induces neurite outgrowth and differentiation in an autophagy-independent manner in PC12 and C17.2 cells, Front Cell Infect Mi.. 2018, doi: 10.3389/fcimb.2018.00201, IF=3.52

Liu WL, Li JP, Wu YX, Xing S, Lai YZ, Zhang G*. Target-induced proximity ligation triggers recombinase polymerase amplification and transcription-mediated amplification to detect tumor-derived exosomes in nasopharyngeal carcinoma with high sensitivity. Biosensors & Bioelectronics, 2018, 102:204-210, IF=8.173

Xue Y, Xiao H, Guo S, Xu B, Liao Y, W u Y, Zhang G*.Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages. Cell Death & Disease. 2018, 9(3):355, IF=5.638

Guo SH, Wang HF, Nian ZG, Wang YD, Zeng QY,Zhang G*. Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal. Scientific Reports. 2017, 7:10566, IF=4.122

Feng XW, Wang QF, Liao YH, Zhou X,Wang YD, Liu WL, Zhang G*. A synthetic urinary probe coated nanoparticles sensitive to fibroblast activation protein-α for solid tumor diagnosis. Int J Nanomed. 2017,12 :5359-5372, IF=4.370

 Liao Y, Xing S, Xu BL, Liu W, Zhang G*. Evaluation of the circulating level of fibroblast activation protein α for diagnosis of esophageal squamous cell carcinoma. Oncotarget. 2017, 8(18):30050-30062

Feng XW, Lin JH, Xing S, Liu WL,Zhang G*. Higher IGFBP-1 to IGF-1 serum ratio predicts unfavourable survival in patients with nasopharyngeal carcinoma. BMC Cancer. 2017,17:90,  IF=3.288

Wang HF, Li LF, Guo SH, Zeng QY, Ning F, Liu WL,Zhang G*. Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer. Sci Rep. 2016, 6:33440,  IF=4.122

Liu WL, Liu D, Cheng K, Liu YJ, Xing S, Chi PD, Liu XH, Xue N, Lai YZ, Guo L,Zhang G*. Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer. Oncotarget. 2016, 7(19): 28124-28138

Wang WF, Ning F, Xue Y, Feng XW, Du J, Zhang G*. iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice. Tumor Biol. 2016, 37(8):10643-52

Liao Y, Xue Y, Zhang L, Feng X, Liu W, Zhang G*.  Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients. J Transl Med. 2015,13:338,  IF=4.197

Liu WL, Lin YH, Xiao H, Xing S, Chen H, Chi PD, Zhang G*.  Epstein-Barr virus iifection induces indoleamine 2,3-Dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-κB pathways: impairment in T cell functions. J Virol. 2014, 88(12):6660-6671,  IF=4.368

Ma C, Ling Q, Xu S, Zhu H,Zhang G* et al. Preparation of biocompatible aggregation- induced emission homopolymeric nanoparticles for cell imaging. Macromol Biosci. 2014, 14(2):235-43. 

Wang H, Zhang G, Zhang H, et al. Acquisition of epithelial-mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway.Eur J Pharmacol. 2014, 723:156-66.

 Fang R, Zhang G, Guo Q, et al. Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma. Cancer Lett. 2013, 333(1):66-75.

 Wang JY, Zheng YZ, Yang J, Lin YH, Dai SQ, Zhang G*.  Elevated levels of serum amyloid A indicate poor prognosis in patients with esophageal squamous cell carcinoma. BMC Cancer. 2012, 12:365

 Zhang G, Liu WL, Zhang L, et al. Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8+ T-Cell Functions in Esophageal Squamous Cell Carcinoma. Clin Dev Immunol. 2011, 384726

Yi YM, Zhang G, Zeng J, et al. A new tumor vaccine: FAPτ-MT elicits effective antitumor response by targeting indolamine2,3-dioxygenase in antigen presenting cells. Cancer Biol Ther. 2011, 11(10):866-73.

Xu BL#, Zhang G#, Ye H,  et al. The predominance of the Hungarian clone (ST 239-III) amongst hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates recovered throughout mainland China. J Hospt Infect. 2009, 71(3):245-255. 

Guo XZ#, Zhang G#, Wang JY, et al. Prognostic relevance of Centromere protein H expression in esophageal carcinoma. BMC Cancer. 2008, 8(1):233 

Liu WL, Zhang G, Wang JY, et al. Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma. B.B.R.C. 2008,  375(3):440-445

Liu W, Tang L, Zhang G, et al. Characterization of a novel c-type lectin-like gene, LESCtin: demonstration of carbohydrate binding and expression in sinusoidal endothelia cells of liver and lymph node. J. Biol. Chem. 2004, 279(18):18748-18758.

其他

教学著

《微生物与免疫学》,科学出版社,副主编,2016.12

《基因工程药物》人民卫生出版社,参编,2016.03

《微生物与免疫学》十一五规划教材,人民卫生出版社,参编,2013.09

《微生物与免疫学习题集》人民卫生出版社,参编,2007.08

《医药分子生物学实验教程》中山大学出版社,参编,2008.03