简单介绍

王洪根  男,博士,中山大学教授,博导。2013年9月通过“中山大学百人计划急需人才计划”进入中山大学药学院工作。曾入选广东省高等学校“优秀青年教师培养计划”、广东省特支计划百千万工程青年拔尖人才和广东省高等学校“千百十人才培养工程”校级培养对象。现为岭南有机化学专业委员会委员,广东省药学会第十七届理事会药物化学专业委员会委员。曾获中国科学院优秀博士学位论文奖,中国科学院院长奖学金优秀奖,广州市科技进步二等奖(排名第二)。主要研究领域为有机合成化学、药物合成化学、天然产物全合成等。至今在J. Am. Chem. Soc.,Angew. Chem. Int. Ed., Science (perspective), ACS Catal.等杂志发表论文30余篇,文章累计被引用1300余次。目前主持青年千人计划启动基金,中山大学“百人计划”启动基金,国家自然科学基金面上项目,国家自然科学基金青年科学基金等多个基金项目。

ORCID: http://orcid.org/0000-0002-9648-6759

研究方向

合成化学,天然产物全合成,药物化学

教育经历

2011年9月至2013年8月:博士后,德国明斯特大学,合作导师:Prof. Dr. Frank Glorius;
2006年9月至2011年7月:博士,中国科学院广州生物医药与健康研究院,导师:朱强 研究员,张健存 研究员;
2005年7月至2005年8月:交换生,香港理工大学应用生物及化学科技学系;
2002年9月至2006年7月:理学学士,双专业:药学 & 计算机科学,中山大学药学院,中山大学计算机科学系。

教学情况

有机化学

药物合成策略与实例

大学化学实验

论著专利

发表论文情况:

(1)       Wang, H.;* Zeng, Y.-F.; Lv W.-X.; Tan D.-H. “Synthetic Transformations of Alkenyl MIDA Boronates toward the Efficient Construction of Organoborons”, Synlett 2018, DOI: 10.1055/s-0036-1591958 (invited Synpacts contribution)

(2)       Yang, L.;‡ Ji, W.-W.;‡ Lin, E; Li, J.-L.; Fan, W.-X. Li, Q.; Wang, H.* “Synthesis of Alkylated Monofluoroalkenes via Fe-catalyzed Defluorinative Cross-Coupling of Donor Alkenes with gem-Difluoroalkenes” Org. Lett. 2018, DOI: 10.1021/acs.orglett.8b00471

(3)       Tan, D. H.; Lin, E.; Ji, W.-W.;  Zeng, Y.-F.; Fan, W.-X.; Li, Q.; Gao, H.;* Wang, H.* “Copper-Catalyzed Stereoselective Defluorinative Borylation and Silylation of gem-Difluoroalkenes” Adv. Syn. Catal. 2018, 360, 1032-1037.

(4)       Zeng, Y.-F.; Ji, W.-W.; Lv, W.-X.; Chen, Y.; Tan, D.-H.; Li, Q.; Wang, H.* “Stereoselective Direct Chlorination of Alkenyl MIDA Boronates: Divergent Synthesis of E and Z α-Chloroalkenyl Boronates” Angew. Chem. Int. Ed. 2017, 56, 14707-14711.

(5)       Chen, S.-Y.; Li, Q.;* Wang, H.* “Manganese(I)-Catalyzed Direct C–H Allylation of Arenes with Allenes” J. Org. Chem. 2017, 82, 11173−11181.

(6)       Zhang, S.-S.; Xia, J.; Wu, J.-Q.; Liu, X.-G.; Zhou, C.-J.; Li. Q.; Huang, S.-L.;* Wang, H.* “Three-Component Catalytic Carboxygenation of Activated Alkenes Enabled by Bimetallic Rh(III)/Cu(II) Catalysis” Org. Lett. 2017, 19, 5868−5871.

(7)       Liu, X.-G.; Gao, H.; Zhang, S.-S.; Li, Q.; Wang, H.* "N-O Bond as External Oxidant in Group 9 Cp*M(III)-Catalyzed Oxidative C−H Coupling Reactions" ACS Catal. 2017, 7, 5078-5086.

(8)       Chen, S.-Y.; Han, X.-L.; Li, Q.;* Chen, Y.; Wang, H.* “Mn(I)-Catalyzed Regio- and Stereoselective 1,2-Diheteroarylation of Allenes via a C-H Activation/Directing Group Migration Cascade” Angew. Chem. Int. Ed. 2017, 56, 9939-9943. (Highlighted in Chin. J. Org. Chem. 2017, 37, 2783-2784.)

(9)       Ji, W.-W.; Lin, E.; Li, Q.; Wang, H.*“Heteroannulation enabled by a bimetallic Rh(III)/Ag(I) relay catalysis: application in the total synthesis of aristolactam BII”Chem. Commun., 2017, 53, 5665 – 5668.

(10)   Chen, S.-Y.; Li, Q.;*Liu, X.-G.; Wu, J.-Q.; Zhang, S.-S.; Wang, H.* “Polycyclization Enabled by Relay Catalysis: One-Pot Manganese-Catalyzed C-H Allylation and Silver-Catalyzed Povarov Reaction” ChemSusChem, 2017, 10, 2360-2364.

(11)   Liu, X.-G.; Li, Q.; Wang, H.* “(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Direct Trifluoromethylthiolation of Arenes via C-H Activation” Adv. Synth. Catal., 2017, 359, 1942-1946.

(12)   Wu, J.-Q.; Zhang, S.-S.; Gao, H.; Qi, Z.; Zhou, C.-J.; Ji, W.-W.; Liu, Y.; Chen, Y.; Li, Q.; Li, X.;* Wang, H.* “Experimental and Theoretical Studies on Rhodium-Catalyzed Coupling of Benzamides with 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Fluorinated Heterocycles” J. Am. Chem. Soc. 2017, 139, 3537-3545.

(13)   Tan, D.-H.; Zeng, Y.-F.; Liu, Y.; Lv, W.-X.; Li, Q.; Wang, H.* “Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence” ChemistryOpen 2016, 5, 535–539.

(14)   Liu, Y.; Zhou, C.-J.; Li, Q.;* Wang, H.* “Total synthesis of (±)-ganocins B and C” Org. Biomol. Chem. 2016, 14, 10362-10365.

(15)   Lv, W.-X.;‡ Zeng, Y.-F.;‡ Li, Q.; Chen, Y.; Tan, D.-H.; Yang, L.; Wang, H.* “Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform to Halogenated and Trifluoromethylated α-Boryl Ketones” Angew. Chem. Int. Ed. 2016, 55, 10069-10073.

(16)   Lao, Y.-X.; Zhang, S.-S.; Liu, X.-G.; Jiang, C.-Y.; Wu, J.-Q.; Chen, S.-Y.; Li, Q.; Huang, Z.-S.; Wang, H.* “High-Valent Cp*Co(III) or Cp*Ir(III)-Catalyzed C–H Annulation with Alkynes: Straightforward Synthesis of Heterocyclic Quaternary Ammonium Salts. Adv. Synth. Catal., 2016, 358, 2186-2191.

(17)   Zhang, S.-S.; Liu, X.-G.; Chen, S.-Y.; Tan, D.-H.; Jiang, C.-Y.; Wu, J.-Q.; Li, Q.*; Wang, H.* “(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines” Adv. Synth. Catal., 2016, 358, 1705-1710.

(18)   Liu, X.-G.; Zhang, S.-S.; Jiang, C.-Y.; Wu, J.-Q.; Li, Q.; Wang, H.* “Cp*Co(III)-Catalyzed Annulations of 2-Alkenylphenols with CO: Mild Access to Coumarin Derivatives Org. Lett., 2015,  17, 5404–5407.

(19)   Zhang, S.-S.;‡ Jiang, C.-Y.;‡ Wu, J.-Q.; Liu, X.-G.; Li, Q.;  Huang, Z.-S.; Li, D.;* Wang, H.* “Cp*Rh(III) and Cp*Ir(III)-catalysed redox-neutral C–H arylation with quinone diazides: quick and facile synthesis of arylated phenols”, Chem. Commun., 2015, 51, 10240-10243.

(20)   Lao, Y.-X.; Wu, J.-Q.; Chen, Y.; Zhang, S.-S.; Li, Q.; Wang H.*Palladium-catalyzed methylene C(sp3)–H arylation of the adamantyl scaffold”, Org. Chem. Front., 2015, 2, 1374-1378. (From themed collection 2015 Emerging Investigators by OCF Hot Articles in August and September)

(21)   Zeng, Y.-F.; Tan, D.-H. Y.; Chen, Y.; Lv, W.-X.;Liu, X.-G.; Li , Q.; Wang, H.* “Direct Radical Trifluoromethylthiolation and Thiocyanation of Aryl Alkynoate Esters: Mild and Facile Synthesis of 3-Trifluoromethylthiolated and 3-Thiocyanated Coumarins”, Org. Chem. Front., 2015, 2, 1511–1515.

(22)   Wu, J.-Q.;, Yang, Z.; Zhang, S.-S.; Jiang, C.-Y.; Li, Q.; Huang, Z.-S.; * Wang H.* “From Indoles to Carbazoles: Tandem Cp*Rh(III)-Catalyzed C–H Activation/Brønsted Acid-Catalyzed Cyclization Reactions”, ACS Catal., 2015, 5, 6453–6457.

(23)   Rao, Y.; Liu, H.; Gao, L.; Yu, H.; Ou, T.-M.; Tan, J.-H.; Huang, S.-L.; Wang, H.; Li, D.; Gu, L.-Q.;  Ye, J.-M.; Huang, Z.-S. “Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment”, J. Med. Chem., 2015, 58, 9395–9413.

(24)   Qiu, J.; Wang, M.; Zhang, Y.; Zeng, P.; Ou, T.-M.; Tan, J.-H.; Huang, S.-L.; An, L.-K.; Wang, H.; Gu, L.-Q.; Huang Z.-S.; Li, D. “Biological Function and Medicinal Research Significance of G-Quadruplex”, Curr. Top. Med. Chem., 2015, 15, 1971-1987

(25)   Lv, W.-X.; Zeng, Y.-F. Zhang, S.-S.; Li, Q.; * Wang H.* “Mild Mn(OAc)3-Mediated Aerobic Oxidative Decarboxylative Coupling of Arylboronic Acids and Arylpropiolic Acids: Direct Access to Diaryl 1,2-Diketones”, Org. Lett., 2015, 17, 2972–2975.

(26)   Liu, X.-G.; Zhang, S.-S.; Wu, J.-Q.; Li, Q.; Wang H.* “CpCo(III)-catalyzed direct functionalization of aromatic C–H bonds with α-diazomalonates”, Tetrahedron Lett., 2015, 56, 4093-4095.

(27)   Zeng, Y.-F.; Tan, D.-H.; Lv, W.-X.; Li, Q.; Wang, H.* “Silver-Catalyzed Aerobic Oxidative Decarboxylative Coupling of Arylpropiolic Acids with H-Phosphine Oxides: Mild and Facile Synthesis of β-Ketophosphine Oxides”, Eur. J. Org. Chem., 2015, 4335–4339

(28)   Zhang, S.-S.; Wu, J.-Q.;Liu, X.; Wang, H.* “Tandem Catalysis: Rh(III)-Catalyzed C–H Allylation/Pd(II)-Catalyzed N-Allylation Toward the Synthesis of Vinyl-substituted N-Heterocycles”, ACS Catal. 2015, 5, 210-214.

(29)   Wu, J.-Q.; Qiu, Z.-P.; Zhang, S.-S.; Liu, J.-G.; Lao, Y.-X.; Gu, L.-Q.; Huang, Z.-S.*; Li, J.*; Wang, H.* “Rhodium(III)-Catalyzed C–H/C–C Activation Sequence: Vinylcyclopropanes as Versatile Synthons in Direct C–H Allylation Reactions”, Chem. Commun., 2015, 51, 77.

(30)   Zhang, S.-S.; Wu, J.-Q.; Lao, Y.-X.; Liu, X.; Liu, Y.; Lv, W.-X.; Tan, D.-H.; Zeng, Y.-F.; Wang, H.* “Mild Rhodium(III)-Catalyzed CH Allylation with 4-Vinyl-1,3-dioxolan-2-ones: Direct and Stereoselective Synthesis of (E)-Allylic Alcohols”, Org. Lett., 2014, 16, 6412–6415.

(31)   Cui, W.; Chen, S.; Wu, J.-Q.; Zhao, X.;*Hu, W.;* H. Wang*, “Palladium-Catalyzed Remote C(sp3)–H Arylation of 3-Pinanamine”, Org. Lett., 2014, 16, 4288.

(32)   Wang, H.; Beiring, B.; Yu, D.-G.; Collins, K.; Glorius, F. “[3]Dendralene Synthesis: Rhodium(III)-Catalyzed Alkenyl C–H Activation and Coupling Reaction with AllenylCarbinol Carbonate.” Angew. Chem. Int. Ed., 2013, 52, 12430.

(33)   Wang, H.; Schröder, N.; Glorius, F. Mild Rh(III)-Catalyzed Direct C-H Allylation of Arenes with Allyl Carbonates.” Angew. Chem. Int. Ed., 2013, 52, 5386.

(34)   Wang, H.; Grohmann, C; Nimphius, C.; Glorius, F.* “Mild Rhodium(III)-Catalyzed C–H Activation and Annulation with Alkyne MIDA Boronates: Short and Efficient Synthesis of Heterocyclic Boronic Acid Derivatives.” J. Am. Chem. Soc., 2012, 134, 19592.

(35)   Wang, H.*; Glorius, F.* Lending Handedness to the Cyclopentadienyl Ligand.” Science, 2012, 338, 479.

(36)   Wang, H.; Glorius, F.* Mild Rh(III)-Catalyzed CH Activation of Aromatic Amide Derivatives and Intermolecular Annulation with Allenes: Efficient Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones.” Angew. Chem. Int. Ed., 2012, 51, 7318.

(37)   Wang, H.; Wang, Y.; Liang, D.; Zhang, J.*; Zhu, Q.* “Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles.” Angew. Chem. Int. Ed., 2011, 50, 5678.

(38)   Wang, H.; Wang, Y.; Peng, C.; Zhang, J.*; Zhu, Q.* “A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines.” J. Am. Chem. Soc., 2010, 132, 13217.

(39)   Wang, H.; Zhao, J.; Zhang, J.; Zhu, Q.* “BrønstedAcid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-spiro-3,4-dihydro-2-(1H)-quinazolinones.” Adv. Synth. Catal., 2011, 353, 2653.

(40)   Wang, H.; Liu, L.; Wang, Y.; Peng, C.; Zhang, J.*; Zhu, Q.* “An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas.” Tetrahedron Lett. 2009, 50, 6841-6843.

 

 

书籍与专利情况: 

(1) 王洪根,劳业兴,吴家强,张尚师,“一种金刚烷胺类衍生物及其制备方法和应用”,中国专利:ZL 2015 1 0009169.8

(2) 朱强,王洪根,王勇,梁冬冬,刘兰英,张健存,咪唑[1,2-a]吡啶和咪唑醛类化合物的合成方法中国专利:CN102358739

(3) 王洪根, 朱强* 天然产物全合成荟萃-萜类,第14章,科学出版社,北京,2010.