联系方式

办公电话:13302209526

电子邮箱:Lssymc@mail.sysu.edu.cn

办公地址:广州市广州大学城外环东路132号 中山大学药学院408室,邮编:510006

简单介绍

姚美村,中山大学药学院教授,博士生导师。2000年在沈阳药科大学药物分析专业博士毕业,2000-2002年在北京中医药大学中药学博士后工作站工作,2002年至今在中山大学药学院工作,2014年在美国耶鲁大学医学院做访问学者。20175月至今在清远市高新技术产业开发区管委会挂任副主任、在清远市科学技术局挂任党组成员、副局长。目前研究方向为调节Wnt信号通路的创新中药研究,重点在中药调节结直肠癌/胃癌及其干细胞的发生和发展、降低或逆转化疗药物耐药性的物质基础和作用机制研究,也进行抗耐药菌(包括幽门螺杆菌)中药的筛选、评价和转化研究。已主持和参与了包括6项国家自然科学基金在内的多项国家级、省部级课题,发表学术论文百余篇。

研究方向

(1)调节Wnt信号通路的中药筛选和评价研究
(2)抗癌中药的物质基础和作用机制研究
(3)抗耐药菌(包括幽门螺杆菌)中药的筛选、评价和转化研究
(4)中药大数据和数据挖掘

教育经历

(1)1990.09~1994.07  在山东医科大学药学系(现山东大学药学院)药学专业学习,获得理学学士学位。
(2)1994.09~1997.07  在沈阳药科大学攻读药物分析硕士学位。在毕开顺教授指导下从事中药质量控制方法学研究。
(3)1997.09~2000.07  在沈阳药科大学攻读药物分析博士学位。在罗旭教授和毕开顺教授指导下进行中药药效物质基础和质量评价方法学研究。

工作经历

(1)2000.08-2002.07  在北京中医药大学中药学博士后流动站工作。在乔延江教授指导下进行基于中药药性理论的数据挖掘研究。
(2)2002.08-至今  在中山大学药学院工作。主要进行药物分析相关的教学和科研工作。
(3)2013.12-2014.12  在耶鲁大学医学院药理系郑永齐(Yung-Chi Cheng)教授实验室做访问学者,主要进行基于核受体的抗癌中药筛选和作用机理研究。

(4)2017.05-至今  在清远国家高新技术产业开发区管委会挂任副主任,分管企业服务局的工作;在清远市科学技术局挂任党组成员、副局长,协管产学研工作。

教学情况

讲授的课程有:

1、本科生

《药物分析》(理论课)

《药物分析》(实验课)

《药物分析经典案例》

2、研究生

《试验设计与数据分析》

社会/学术任职

国家自然科学基金项目一审评委
博士后、博士点以及广东省、山东省、河北省、广州市等相关基金项目评委

世中联中药系统科学与工程专业委员会常务理事

科研项目

(1)2015年国家自然科学基金资助面上项目“基于整体观的芦荟激活Wnt/Beta-Catenin/APC信号通路的物质基础和作用机理研究”(编号81573689),2016.01~2019.12,主持人。
(2)2015年国家自然科学基金资助地区项目“基于肠道菌群和代谢组学的’西帕依溃结安-短链脂肪酸’协同作用机制研究”(编号81560699),2016.01~2019.12,第一参与人(主持人韩博教授)。
(3)2013年国家自然科学基金资助面上项目“基于体内过程的酒制大黄缓和泻下和酒制升提药性研究”(编号81274102),2013.01~2013.12,主持人。
(4)2008年国家自然科学基金资助面上项目“大黄黄连泻心汤主要化学成分分析与生理药动学研究”(编号30873428),2009.01~2011.12,主持人。
(5)2006年国家自然科学基金资助青年基金项目“中药冰片归经的生理药动学研究”(编号30600825),2007.01~2009.12,主持人。
(6)2003年国家自然科学基金资助面上项目“中药药性理论的数据挖掘研究”(编号30371784),2004.01~2006.12,第二参与人(主持人乔延江教授)
(7)其他项目若干。

论著专利

  1. Meng-ping Liu, Wa Li, Cong Dai, Christopher Wai Kei Lam, Zheng Li, Jie-feng Chen, Zuan-guang Chen, Wei Zhang, Mei-cun Yao. Aqueous extract of Sanguisorba officinalis blocks the Wnt/β-catenin signaling pathway in colorectal cancer cells. RSC Advances2018,89):10197-10206
  2. Jiefeng Chen, Shaodong Li, Mengping Liu, Christopher Wai Kei Lam, Zheng Li, Xinjun Xu, Zuanguang Chen, Wei Zhang, Meicun Yao. Bioconcentration and metabolism of emodin in zebrafish eleutheroembryos. Frontiers in Pharmacology, 2017, 8:453. DOI: 10.3389/fphar.2017.00453
  3. Cong Dai, Meng-ping Liu,Wei-jia Zhang,Christopher Wai Kei Lam, Jian-ru Guo,Wa Li,Juan Wu,Jie-feng Chen, Zuan-guang Chen,Wei Zhang, Mei-cun Yao. A Material-Basis Study of Aloe Vera on the Wnt/β-Catenin Signaling Pathway using a Knockin/Knockout Method with High-Speed Countercurrent Chromatography. RSC Adv. 2017,7,38819
  4. Meng-ping Liu, Min Liao, Cong Dai, Jie-feng Chen, Chun-juan Yang, Ming Liu, Zuan-guang Chen, Meicun Yao.2016Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase dependent apoptotic pathway. Sci. Rep. 6, 34245; doi: 10.1038/srep34245 (2016).
  5. Min Liao Cong Dai, Mengping Liu, Jiefeng Chen, Zuanguang Chen, Zhiyong Xie, Meicun Yao. Simultaneous determination of four furostanol glycosides in rat plasma by UPLC–MS/MS and its application to PK study after oral administration of Dioscorea nipponica extracts. Journal of Pharmaceutical and Biomedical AnalysisISSN0731-70852016117:372-379.
  6. Min Liao, Xiao Chen, Jiefeng Chen, Mengping Liu, Junyi Wang, Zuanguang Chen, Zhiyong Xie, Meicun Yao. Determination of pseudoprotodioscin in rat plasma by UPLC–MS/MS: Assay development and application to pharmacokinetic study. Journal of Chromatography BISSN1570-0232),10262016):97-104
  7. Shuzhen Zhu, Jingwen Gao, Zhan Shi, George Q Li, Zuanguang ChenMeicun Yao. Inhibitory effect of Aristolochia fruit on Cytochrome P450 isozymes in vitro and in vivo. Pakistan journal of pharmaceutical sciences (ISSN: 1011-601X), 2015283):939-944
  8. Yanyan Yu, Zuanguang Chen, Sijing He, Beibei Zhang, Xinchun Li, Meicun Yao. Direct electron transfer of glucose oxidase and biosensing for glucose based on PDDA-capped gold nanoparticle modified graphene/multi-walled carbon nanotubes electrode. Biosensors and Bioelectronics, 201452:147152
  9. Yanyan Yu, Zuanguang Chen, Wensi Jian, Duanping Sun, Beibei Zhang, Xinchun Li, Meicun Yao. Ultrasensitive electrochemical detection of avian influenza A (H7N9) virus DNA based on isothermal exponential amplification coupled with hybridization chain reaction of DNAzyme nanowires. Biosensors and Bioelectronics, 2015,64: 566-571.
  10. Xiao Chen, Zhong Wang, Mengping Liu, Min Liao, Xinfeng Wang, Huajuan Du, Jiefeng Chen, Meicun Yao, Qing Li. Determination of sunitinib and its active metabolite, Ndesethyl sunitinib in mouse plasma and tissues by UPLCMS/MS: assay development and application to pharmacokinetic and tissue distribution studies. Biomedical Chromatography, 2015, 295):679-688
  11. Zhan Shi, Jingwen Gao, Yuemei Yuan, Shuzhen Zhu, Meicun Yao Effect of raw Radix Rehmanniae on the pharmacokinetics of pioglitazone in rats. Pakistan journal of pharmaceutical sciences, 2014, 27(3): 537-539
  12. Xinchun Li, Zuanguang Chen, Jianbin Pan, Fan Yang, Yinbao Li, Meicun Yao. Differential pulsed amperometry coupled to microchip capillary electrophoresis. Journal of Chromatography A. 201324174-178
  13. Xiao Chen, Jingwen Gao, Yiming Jiang, Ping Huang, Yuhui Xie, Rongbiao Pi, Shuzhen ZhuMeicun Yao. Determination of newly synthesized lipoic acidniacin dimer in rat plasma by UPLC/electrospray ionization tandem mass spectrometry: assay development, validation and application to a pharmacokinetic study. Biomedical Chromatogarphy. 2014,282):213-217
  14. Jingwen Gao, Zhan Shi, Shuzhen Zhu, George Li, Ru Yan, Meicun Yao. (2012) Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches. Journal of Ethnopharmacology. 2013, 145:566-572
  15. Wang S, Chen Z, Tang X, Shi L, Zhang L, Yao M.(2013) Rapid determination of partition coefficients of pharmaceuticals by phase distribution and microchip capillary electrophoresis with contactless conductivity detection. J Sep Sci. Sep 10. doi: 10.1002/jssc.201300720.
  16. Qiao S, Shi X, Shi R, Liu M, Liu T, Zhang K, Wang Q, Yao M, Zhang L. (2013) Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques. Analytical and bioanalytical chemistry. 405(21):6721-38
  17. Meicun Yao, Jingwen Gao, George Q. Li, Zhiyong Xie. (2012) Quantifying four-probe metabolites in a single UPLC–MS/MS run to explore the effects of cooked rhubarb on cytochrome P450 isozymes. Bioanalysis, 2012,4(22):2693-2703
  18. Yue-mei Yuan, Jing-wen Gao, Zhan Shi, Ping Huang, Ya-song Lu, Mei-cun Yao, Min Huang.(2012) Herb-Drug Pharmacokinetic Interaction between Radix astragali and Pioglitazone in Rats. Journal of Ethnopharmacology. 144,300-304. DOI: 10.1016/j.jep.2012.09.012
  19. Ping Huang, Jing-wen Gao, Zhan Shi, Jia-li Zou, Ya-song Lu, Yue-mei Yuan, Mei-cun Yao.(2012) A novel UPLC–MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study. Bioanalysis, 4(10):1205~1213
  20. Jing-wen Gao, Yue-mei Yuan, Ya-song Lu, Mei-cun Yao (2012). Development of a rapid UPLC-MS/MS method for quantification of saxagliptin in rat plasma and application to pharmacokinetic study. Biomedical Chromatography, 26(12):1482-7, DOI 10.1002/bmc.2720.
  21. 最近参与编写的教材有:

        分析化学(主编黄承志教授),科学出版社

        分析化学(主编王嗣岑教授),科学出版社

        药物分析(主编杭太俊教授),化学工业出版社