简单介绍

袁燕秋,博士,中山大学药学院副教授/博士生导师,中山大学"百人计划"二期引进人才。回国前长期在世界三大药企之一的诺华制药(Novartis)的肿瘤分部担任研究员(Investigator),带领生化团队参与研发多个新型小分子抗癌药物。袁燕秋博士在PNAS, JACS,JMC等期刊上发表多篇论文,目前研究聚焦于蛋白质翻译后修饰相关的药物靶标发现、药物筛选,以及相关化学生物学、药理学研究。

 

教育经历

2008年,理学博士,化学与化学生物学系,美国哈佛大学,论文导师: Suzanne Walker                                                

2003年,理学学士,应用化学系, 中国科学技术大学

         

工作经历

2017年9月 - 至今             中山大学副教授

2015年1月 - 2017年8月   丹麦哥本哈根大学助理教授

2011年8月 - 2014年12月 美国诺华生物医学研究所(NIBR)二级研究员(Investigator II)        

2008年8月 - 2011年7月   美国诺华生物医学研究所(NIBR)一级研究员(Investigator I)

 

科研项目

中山大学“百人计划二期”启动项目

 

论著专利

1.     Chen X, Giraldes J, Sprague ER, Shakya S, Chen Z, Wang Y, Joud C, Mathieu S, Chen CH, Straub C, Duca J, Hurov K, Yuan Y, Shao W, Touré BB. "Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors. J. Med. Chem.2017, 60, 2155-2161.

2.     Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K, Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J. Med. Chem.2016, 59, 4711-23. 

3.     Six DA, Yuan Y, Leeds JA, Meredith TC.  Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility. Antimicrob. Agents Chemother.201458, 153-161.

4.     Yuan Y, Sachdeva M, Leeds JA, Meredith TC.  Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases. J. Bacteriol.2012194, 5171-5184.  

5.     Yuan Y, Leeds JA, Meredith TC.  Pseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesis. J. Bacteriol., 2012194, 5185-5196.

6.     Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D.  Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chemical Biology20105, 701-11.

7.     Yuan Y, Fuse S, Sliz P, Kahne D, Walker S.  Structural and functional analysis of the H-bonding network that anchors moenomycin in the peptidoglycan glycosyltransferase active site: implications for antibiotic design. ACS Chemical Biology20083, 429-436.

8.     Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S.  Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J. Biol. Chem.,2007208, 31964-31971.

9.     Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc. Natl. Acad. Sci. U. S. A.2007104, 5348-5453.

10.  Ginsberg C, Zhang YH, Yuan Y, Walker S.  In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis. ACS Chem. Biol.20061, 25-28.

11.  Zhang YH, Ginsberg C, Yuan Y, Walker S.  Substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Biochemistry200645, 10895-10904.

12.  Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S.  In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J. Am. Chem. Soc.2005127, 14128-14129.

13.  Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S.  Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. J. Am. Chem. Soc.2004126, 7462-7463.