联系方式

办公电话:020-39943044

电子邮箱:chenzg@mail.sysu.edu.cn

办公地址:(510006)广州市大学城外环东路132号中山大学药学院

简单介绍

陈缵光,男,1961年生,博士。中山大学药学院教授,药物分析专业和生物医学工程专业博士生导师,分析仪器研究所所长。广东省政协常委。

承担多门本科生和研究生课的教学。科学研究领域包括分析仪器与医学仪器、药物分析、药物筛选、生物传感器、临床化学、日用化工等。带领团队主要从事仪器研制、药物与体内代谢物分析,基于微流控芯片技术在斑马鱼、线虫、细胞和酶水平的药物筛选与评价,保健品、消毒药械等研究。作为负责人主持国家级项目6项(重点项目1项)、省部级项目3项、企业项目多项;作为主要成员参与各种项目多项。在Analytical Chemistry, Biosensors and Bioelectronics, Lab on a Chip等国内外期刊发表论文180多篇,申请专利10多项,获广东省科学技术奖一等奖、二等奖和三等奖各1项。研制的毛细管电泳仪和微流控芯片分析仪已在多个单位使用。兼任广东省科技咨询专家、广东省重大行政决策咨询论证专家、新药评审专家,《分析测试学报》编委等。

研究方向

分析仪器与医学仪器、药物分析、药物筛选、生物传感器、临床化学、消毒药械和保健品等。

教育经历

1978.3~1982.1 中山大学化学系分析化学专业,理学学士 
1996.9~1998.6 中山大学法律系经济法专业,在职硕士班 
1997.9~2000.6 中山大学化学院分析化学专业,理学博士

工作经历

1982.2~1986.1 北京农业大学,助教 
1986.1~1987.1 广东进出口商品检验局,助理工程师 
1987.1~2004.6 中山医科大学(中山大学)基础医学院,助教、讲师、副教授 
(期间,1992.2~2000 中山医科大学三环专利事务所代理人[兼职])
2004.6~现在 中山大学药学院,副教授、教授、博士生导师 
(期间,2003.9~2006.1 中山大学法医鉴定中心鉴定人[兼职], 
2004.7~2004.12 广东省阳春市人民政府市长助理[挂职])

教学情况

讲授药学本科生“分析化学”(课程负责人)和“药物分析学”,医学本科生“基础化学”,研究生“毛细管电泳和微流控芯片”和“药物分析新进展”等课程。发表教学论文多篇,参编《基础分析化学》(副主编)、《基础仪器分析》(副主编)等高校教材3本,主持学校教学改革项目2项。

社会/学术任职

(1) 广东省政协常委

(2) 《分析测试学报》编委

科研项目

作为负责人主持国家级项目6项(重点项目1项)、省部级项目3项(重点1项),主要涉及微流控芯片和生物传感器等领域。承担企业委托项目多项,主要涉及消毒药械和保健品等。作为主要成员参与各种项目多项。

论著专利

(1)     Xiangyan Wang, Duanping Sun, Yanli Tong*, Yongsheng Zhong, Zuanguang Chen*, A voltammetric aptamer-based thrombin biosensor exploiting signal amplification via synergetic catalysis by DNAzyme and enzyme decorated AuPd nanoparticles on a poly(o-phenylenediamine) support, Microchim Acta, DOI 10.1007/s00604-017-2160-0 (2017)

(2)     Zhixian Liang, Haiyun Zhai, Zuanguang Chen, Shiqiao Wang, Haihang Wang, Shumei Wang, A sensitive electrochemical sensor for flavonoids based on a multi-walled carbon paste electrode modified by cetyltrimethylammonium bromide-carboxylic multi-walled carbon nanotubes, Sensors and Actuators B, 244, 897–906 (2017)

(3)     Wensi Jian, Chunping Wang, Zuanguang Chen*, Yanyan Yu, Duanping Sun, Liping Han and Lijuan Shi, Nonenzymatic Electrochemical Immunosensor Using Ferroferric Oxide–Manganese Dioxide–Reduced Graphene Oxide Nanocomposite as Label for α-Fetoprotein Detection, NANO, 11(10) 1650116 (12 pages) (2016)  

(4)     HE Qi-Di, HUANG Dan-Ping, HUANG Guan, CHEN Zuan-Guang*, Advance in Research of Microfluidic Polymerase Chain Reaction Chip, Chinese Journal of Analytical Chemistry, 44(4): 542–550 (2016)   

(5)     Fan Yang*, Chuan Gao, Ping Wang, Guo-Jun Zhang* and Zuanguang Chen, Fish-on-a-chip: microfluidics for zebrafish research, Lab on a Chip, 16, 1106–1125 (2016)  

(6)     Duanping Sun, Jing Lu, Yuwen Zhong*, Yanyan Yu, Yu Wang, Beibei Zhang, Zuanguang Chen*, Sensitive electrochemical aptamer cytosensor for highly specific detection of cancer cells based on the hybrid nanoelectrocatalysts and enzyme for signal amplification, Biosensors and Bioelectronics, 75, 301–307 (2016)

(7)     Min Liao, Xiao Chen, Jiefeng Chen, Mengping Liu, Junyi Wang, Zuanguang Chen, Zhiyong Xie, Meicun Yao, Determination of pseudoprotodioscin in rat plasma by UPLC–MS/MS: Assay development and application to pharmacokinetic study, Journal of Chromatography B, 1026, 97–104 (2016)

(8)     Min Liao, Cong Dai, Mengping Liu, Jiefeng Chen, Zuanguang Chen, Zhiyong Xie, Meicun Yao, Simultaneous determination of four furostanol glycosides in rat plasma by UPLC–MS/MS and its application to PK study after oral administration of Dioscorea nipponica extracts, Journal of Pharmaceutical and Biomedical Analysis, 117, 372–379  (2016)

(9)     Meng-ping Liu, Min Liao, Cong Dai, Jie-feng Chen, Chun-juan Yang, Ming Liu, Zuan-guang Chen, Mei-cun Yao*, Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen speciesmediated mitochondria-caspase dependent apoptotic pathway, Scientific Reports, 6:34245, DOI: 10.1038/srep 34245 (2016)

(10)  Zhixian Liang, Haiyun Zhai*, Zuanguang Chen*, Haihang Wang, Shumei Wang, Qing Zhou, Xiaoting HuangA simple, ultrasensitive sensor for gallic acid and uric acid based on gold microclusters/sulfonate functionalized graphene modified glassy carbon electrode, Sensors and Actuators B: Chemical, 224,915–925 (2016)

(11)  Haihang Wang, Haiyun Zhai*, Zuanguang Chen, Zhixian Liang, Shumei Wang, Qing Zhou and Yufang Pan, The electrochemical behaviors of tetrahydropalmatine at a nickel nanoparticles/sulfonated graphene sheets modified glassy carbon electrode, RSC Adv., 6, 71351-71359 (2016)

(12)  Duanping Sun, Jing Lu, Zuanguang Chen*, Microfluidic contactless conductivity cytometer for the electrical cell sensing and counting, RSC Adv., 5, 59306–59313 (2015)

(13)  Duanping Sun, Jing Lu, Zuanguang Chen*, Yanyan Yu, Manni Mo, A repeatable assembling and disassembling electrochemical aptamer cytosensor for ultrasensitive and highly selective detection of human liver cancer cells, Analytica Chimica Acta, 885, 166–173 (2015)

(14)  Lijuan Shi, Yanyan Yu, Zuanguang Chen*, Lin Zhang, Sijing He, Qiujia Shi and Hongzhi Yang*, A label-free hemin/G-quadruplex DNAzyme biosensor developed on electrochemically modified electrodes for detection of a HBV DNA segment, RSC Adv., 5, 11541–11548  (2015)

(15)  Yinbao Li, Xiujuan Yang, Zuanguang Chen*, Beibei Zhang, Jianbin Pan, Xinchun Li, Fan Yang, and Duanping Sun, Comparative toxicity of lead (Pb2+), copper (Cu2+), and mixtures of lead and copper to zebrafish embryos on a microfluidic chip, Biomicrofluidics, 9, 024105 (2015)

(16)  Sijing He, Qiyou Wang*, Yanyan Yu, Qiujia Shi, Lin Zhang, Zuanguang Chen*, One-step synthesis of potassium ferricyanide-doped polyaniline nanoparticles for label-free immunosensor, Biosensors and Bioelectronics, 68, 462467 (2015)

(17)  Xiujuan Yang, Cui Liu, Zuanguang Chen*, Rapid Determination of Uric Acid in Human Urine by CE with an Improved Electromagnetic Induction Detector, Chromatographia, 78,119-123 ( 2015)

(18)  Yanyan Yu, Zuanguang Chen*, Wensi Jian, Duanping Sun, Beibei Zhang, Xinchun Li, Meicun Yao*, Ultrasensitive electrochemical detection of avianinfluenza A(H7N9) virus DNA based on isothermal exponential amplification coupled with hybridization chain reaction of DNAzyme nanowires, Biosensors and Bioelectronics, 64, 566–571 (2015)

(19)  Sijing He, Yanyan Yu, Zuanguang Chen*, Qiujia Shi, Lin Zhang, Synergistic Effect of Graphene and Multiwalled Carbon Nanotubes on a Glassy Carbon Electrode for Simultaneous Determination of Uric Acid and Dopamine in the Presence of Ascorbic Acid,  Analytical Letters, 48, 248–258 (2015)

(20)  Haiyun Zhai*, Zihao Su, Zuanguang Chen*, Zhenping Liu, Kaisong Yuan, Lu Huang, Molecularly imprinted coated graphene oxide solid-phase extraction monolithic capillary column for selective extraction and sensitive determination of phloxine B in coffee bean, Analytica Chimica Acta, 865, 16–21 (2015)

(21)  Haiyun Zhai*, Zhenping Liu, Zuanguang Chen*, Zhixian Liang, Zihao Su, Shumei Wang, A sensitive electrochemical sensor with sulfonated graphenesheets/oxygen-functionalized multi-walled carbon nanotubesmodified electrode for the detection of clenbuterol, Sensors and Actuators B, 210, 483–490 (2015)

(22)  Haiyun Zhai*, Zhixian Liang, Zuanguang Chen*, Haihang Wang, Zhenping Liu, Zihao Su, Qing Zhou, Simultaneous detection of metronidazole and chloramphenicol by differential pulse stripping voltammetry using a silver nanoparticles/ sulfonate functionalized graphene modified glassy carbon electrode, Electrochimica Acta, 171, 105–113 (2015)

(23)  Haiyun Zhai*, Kaisong Yuan, Xiao Yu*, Zuanguang Chen, Zhenping Liu, Zihao Su, A simple and compact fluorescence detection system for capillary electrophoresis and its application to food analysis,  Electrophoresis, 36, 2509–2515, 2015

(24)  Kaisong Yuan, Jianzhuang Wang, Haiyun Zhai*, Zuanguang Chen*, Lu Huang, and Zihao Su, Sensitive determination of rose bengal in brown sugar by a molecularly imprinted solid-phase extraction monolithic capillary column coupled with capillary electrophoresis, Analytical Methods, 7, 8297–8303, 2015

(25)  Yanyan Yu, Zuanguang Chen*, Lijuan Shi, Fan Yang, Jianbin Pan, Beibei Zhang, and Duanping Sun, Ultrasensitive Electrochemical Detection of MicroRNA Based on an Arched Probe Mediated Isothermal Exponential Amplification, Analytical Chemistry, 86(16), 8200−8205 (2014)

(26)  Beibei Zhang, Yinbao Li, Qidi He, Jun Qin, Yanyan Yu, Xinchun Li, Lin Zhang, Meicun Yao, Junshan Liu, and Zuanguang Chen*, Microfluidic platform integrated with worm-counting setup for assessing manganese toxicity, Biomicrofluidics, 8, 054110 (2014)

(27)  Sijing He, Zuanguang Chen*, Yanyan Yu and Lijuan Shi, A novel non-enzymatic hydrogen peroxide sensor based on poly-melamine film modified with platinum nanoparticles, RSC Advances, 4, 45185-45190, (2014)

(28)  Duanping Sun, Jing Lu, Zuanguang Chen*, Yanyan Yu, Yinbao Li, A novel three-dimensional microfluidic platform for on chip multicellular tumor spheroid formation and culture, Microfluid and Nanofluid, 17,831–842 (2014)

(29)  Yinbao Li, Fan Yang, Zuanguang Chen*, Lijuan Shi, Beibei Zhang, Jianbin Pan, Xinchun Li, Duanping Sun, Hongzhi Yang*, Zebrafish on a Chip: A Novel Platform for Real-Time Monitoring of Drug-Induced Developmental Toxicity, PLos ONE, 9(4): e94792. (2014)

(30)  Yanyan Yu, Zuanguang Chen*, Sijing He, Beibei Zhang, Meicun Yao*, Direct electron transfer of glucose oxidase and biosensing for glucose based on PDDA-capped gold nanoparticle modified graphene/multiwall carbon nanotubes electrode, Biosensors and Bioelectronics, 52, 147–152 (2014)

(31)  Jianbin Pan, Zuanguang Chen*, Meicun Yao, Xinchun Li, Yinbao Li, Duanping Sun and Yanyan Yu, A two-electrode system-based electrochemiluminescence detection for microfluidic capillary electrophoresis and its application in pharmaceutical analysis, Luminescence, 29, 427–432 (2014)

(32)  Jianping Yang, Zuanguang Chen*, Poying Ching, Qiujia Shi and Xinchun Li, An integrated microfluidic platform for evaluating in-vivo antimicrobial activity of natural compounds using a whole-animal infection model, Lab on a Chip, 13 (17), 3373 - 3382,  (2013)

(33)  Sifeng Wang, Zuanguang Chen*, Xiuwen Tang, Lijuan Shi, Lin Zhang, Meicun Yao*, Rapid determination of partition coefficients of pharmaceuticals by microchip capillary electrophoresis with contactless conductivity detection, Journal of Separation Science, 36, 3615–3622 (2013)

(34)  Beibei Zhang, Zuanguang Chen*, Yanyan Yu, Jianping Yang, Jianbin Pan, Determination of sulfonamides in pharmaceuticals and rabbit plasma by microchip electrophoresis with LED-IF detection, Chromatographia, 76:821–829 (2013)

(35)  Jianbin Pan, Xinchun Li, Zuanguang Chen*, Fan Yang, Xiaohang Wu, Yinbao Li, Duanping Sun, Yanyan Yu, A beveled working electrode coupled to a sandglass shape detection cell: A strategy to improve the sensitivity of electrochemiluminescence detection in microchip electrophoresis, Electrochimica Acta, 90, 101–107 (2013)

(36)  Zhirui Song, Yue Xu*, Zuanguang Chen*, Jianping Yang, Xinchun Li, Zhiguang Zhang, Quantification of lactate in synovia by microchip with contactless conductivity detection, Analytical Biochemistry, 434, 73–77 (2013)

(37)  Xinchun Li, Zuanguang Chen*, Jianbin Pan; Fan Yang; Yinbao Li; Meicun Yao*, Differential pulsed amperometry coupled to microchip capillary electrophoresis, Journal of Chromatography A, 1291, 174-178 (2013)

(38)  Xinchun Li, Zuanguang Chen*, Fan Yang, Jianbin Pan, Yinbao Li, Development of a microchip-pulsed electrochemical method for rapid determination of L-DOPA and tyrosine in Mucuna pruriens, Journal of Separation Science, 36, 1590–1596 (2013)

(39)  YanyanYu, Zuanguang Chen*, Beibei Zhang, XinchunLi, Jianbin Pan, Selective and sensitive determination of uric acid in the presence of ascorbic acid and dopamine by PDDA functionalized grapheme/graphite composite electrode, Talanta, 11231– 36 (2013)

(40)  Jianping Yang, Zuanguang Chen*, Fan Yang, Shuping Wang, Fenghua Hou, A microfluidic device for rapid screening of chemotaxis-defective Caenorhabditis elegans mutants, Biomedical Microdevices,15,211–220 (2013)

(41)  Xinchun Li, Zuanguang Chen, Yuwen Zhong*, Fan Yang, Jianbin Pan, Yajing Liang, Cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode as electrochemical sensor on microfluidic chip, Analytica Chimica Acta, 710, 118– 124 (2012)

(42)  Xiu-juan Yang, Jun-Feng, Zuan-guang Chen*, Rifang Liao, Xinchun Li, Determination of six analgesics by capillary electrophoresis with an improved electromagnetic induction Detector, Chromatographia, 75, 71–76 (2012)

(43)  Shuping Wang, Xinchun Li, Jianping Yang, Xiujuan Yang, Fenghua Hou, Zuanguang Chen*, Rapid determination of creatinine in human urine by microchip electrophoresis with LED induced fluorescence detection, Chromatographia, 75, 1287–1293 (2012)

(44)  Junshan Liu, Fei Xu, Sifeng Wang, Zuanguang Chen*, Jianbin Pan, Xinran Ma, Xiaokai Jia, Zheng Xu, Chong Liu, Liding Wang, A polydimethylsiloxane electrophoresis microchip with a thickness controllable insulating layer for capacitatively coupled contactless conductivity detection, Electrochemistry Communications, 25, 147–150 (2012)

(45)  Jin Xiong Qian, Zuan Guang Chen*, A novel electromagnetic induction detector with a coaxial coil for capillary electrophoresis, Chinese Chemical Letters, 23(02), 201-204 (2012)

(46)  Zi-You Cai, Yong-Chong Li, Li-Hua Li, Zuan-Guang Chen*, Analysis of arecoline in Semen Arecae decoction pieces by microchip capillary electrophoresis with contactless conductivity detection, Journal of Pharmaceutical Analysis, 2(5), 356–360 (2012)

(47)  Junshan Liu*, Junyao Wang, Zuanguang Chen, Yong Yu, Xiujuan Yang, Xianbin Zhang, Zheng Xu, Chong Liu, A three-layer PMMA electrophoresis microchip with Pt microelectrodes insulated by a thin film for contactless conductivity detection, Lab on a Chip, 11, 969–973 (2011)

(48)  Fan Yang, Xin-chun Li, Wen Zhang, Jian-bin Pan, Zuan-guang Chen*. A facile light-emitting-diode induced fluorescence detector coupled to an integrated microfluidic device for microchip electrophoresis, Talanta, 84, 1099–1106 (2011)

(49)  Fan Yang, Zuanguang Chen*, Jianbin Pan, Xinchun Li, Jun Feng, Hui Yang, An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics, Biomicrofluidics, 5, 024115 (2011)

(50)  Xinchun Li, Jianbin Pan, Fan Yang, Jun Feng, Jinyuan Mo, Zuanguang Chen*, Simple amperometric detector for microchip capillary electrophoresis, and its application to the analysis of dopamine and catechol, Microchim Acta, 174, 123–130 (2011)

(51)  Hui Yang, Xin-chun Li, Fan Yang, Jun Feng, Miao-yin Lin, Zuan-guang Chen*, Electro- chemiluminescence detection system for microchip capillary electrophoresis and its application to pharmaceutical analysis, Microchim Acta, 175, 193–199 (2011)

(52)  Jing Zhao, Zuanguang Chen*, Xinchun Li, Jianbin Pan, A novel microchip based on indium tin oxide coated glass for contactless conductivity detection, Talanta, 85, 2614– 2619 (2011)

(53)  Jun Feng, Xiu-juan Yang, Xin-chun Li, Hui Yang, and Zuan-guang Chen*, An automated fluid-transportation device for microfluidic system, Analytical Sciences, 27, 1057-1060 (2011)

(54)  张雯, 陈缵光*, 冯军, 刘翠, 微孔板发光二极管诱导荧光-表面活性剂增敏法测定盐酸小檗碱, 分析化学, 3981218-22 (2011)

(55)  Xiu-juan Yang, Zuan-guang Chen*, Cui Liu, Ou-lian LiElectromagnetic induction detector for capillary electrophoresis and its application in pharmaceutical analysis, Talanta, 82, 1935–1942 (2010)

(56)  Li Xiang, Tong Yan-li, Liu Cui, Li Ou-lian, Yang Xiu-juan, Chen Zuan-guang*Dual detection methods for microchip and conventional capillary electrophoresesChin J Anal Chem, 37(10), 1547–1554 (2009)

(57)  Zuan-guang Chen*, Ou-lian Li, Cui Liu, Xiu-juan Yang, Electromagnetic induction detector with a vertical coil for capillary electrophoresis and microfluidic chip, Sensors and Actuators B: Chemical, 141, 130-133  (2009)

(58)     童艳丽,李偶连,刘翠,李想,杨秀娟,陈缵光*,微流控芯片电解质介导连接在柱式电导检测,分析化学37(7), 1088-1092  (2009)

(59)     Cui Liu, Yun-yan Mo, Zuan-guang Chen*, Xiang Li, Ou-lian Li, Xie Zhou, Dual fluorescence/contactless conductivity detection for microfluidic chip, Anal Chim Acta, 621, 171  (2008)

(60)     Ou-lian Li, Yan-li Tong, Zuan-guang Chen*, Cui Liu, Shen Zhao, Jin-yuan Mo, A glass/PDMS hybrid microfluidic chip embedded with integrated electrodes for contactless conductivity detection, Chromatographia, 68, 1039–1044 (2008)

(61)     杨秀娟,李偶连,陈缵光*,刘翠,蓝悠,赵慎,微流控芯片非接触电导法测定感冒药中的盐酸伪麻黄碱和氢溴酸右美沙芬,分析化学36(5)673677 (2008)

(62)     Zuanguang Chen*, Quanwen Li, Oulian Li, Xie Zhou, You Lan, Yuanfang Wei, Jinyuan Mo, A thin glass chip for contactless conductivity detection in microchip capillary electrophoresis, Talanta, 71(3), 1944-1950 (2007)


 

获奖情况

(1) 广东省科学技术奖一等奖(粤府证[2015]1668)
(2) 广东省科学技术奖三等奖(粤府证[2013]2149)
(3) 广东省科学技术奖二等奖(粤府证[2005]1179)
(4) 民革全国基层工作先进个人(民革中央2012)
(5) 民革全国祖统工作先进个人(民革中央2010)

其他

近年研制的部分仪器:
(1) 微流控芯片分析仪 
包括:压电陶瓷高压源,自动送液系统,非接触电导、伏安、荧光、电化学发光、磁导(电磁感应)检测,多模式同时检测 
(2) 毛细管电泳仪 
包括:压电陶瓷高压源,伏安、电导、高频电导(非接触电导)、磁导(电磁感应)检测 
(3) 非接触电导检测器 
适配:高效液相色谱(分析或制备)、毛细管电泳、微流控芯片、流动注射分析、细胞计数等 
(4) 关节内压测量仪

(5) 无泄漏臭氧杀菌解毒机