联系方式

办公电话:020-39943036

电子邮箱:limin65@mail.sysu.edu.cn

办公地址:药学院

简单介绍

李民,中山大学“百人计划二期”引进人才,副教授,博士生导师。2007年博士毕业于清华大学生物学专业,2007-2012匹兹堡大学和印第安纳大学博士后和研究助理教授。目前在药学院药理专业从事教学和科研工作,主要开展新药筛选及药理学评价、细胞自噬与疾病的发生机制及相关调节剂研究,主持国家自然科学基金面上项目、广东省自然科学基金等在内的各类科研项目多项,在重要学术期刊Autophagy,Cell Death and Disease,J. Biol. Chem.等发表学术论文30余篇。

教学情况

药理学

药理学实验

药理学进展

病理生理学

药物筛选技术与进展

社会/学术任职

广东省药理学会新药筛选与评价专业委员会,常务委员

科研项目

国自然面上项目(2017-2020)

省自然项目 (2013-2015,2016-2018)

教育部留学回国人员启动基金 2013

教育部博士点新教师基金 2013

百人计划项目启动基金 2013

论著专利 (2010年后

第一/通讯文章

[1] Y. Fu, L. Hong, J. Xu, G. Zhong, Q. Gu, Q. Gu, Y. Guan, X. Zheng, Q. Dai, X. Luo, C. Liu, Z. Huang, X.M. Yin, P. Liu*, M. Li*, Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo, Autophagy, (2018). doi: 10.1080/15548627.2018.1517073

[2] W. Wen, J. Chen, L. Ding, X. Luo, X. Zheng, Q. Dai, Q. Gu, C. Liu, M. Liang, X. Guo, P. Liu*, M. Li*, Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy, Arch Biochem Biophys, 657 (2018) 31-40

[3] J. Chu, Y. Fu, J. Xu, X. Zheng, Q. Gu, X. Luo, Q. Dai, S. Zhang, P. Liu, L. Hong*, M. Li*, ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition, Arch Biochem Biophys, 644 (2018) 29-36.

[4] S.T. Li, Q. Dai, S.X. Zhang, Y.J. Liu, Q.Q. Yu, F. Tan, S.H. Lu, Q. Wang, J.W. Chen, H.Q. Huang, P.Q. Liu*, M. Li*, Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-kappaB signaling pathway and activating the PI3K/Akt/Nrf2 pathway, Acta Pharmacol Sin, 39 (2018) 1294-1304.

[5] M. Li*, Y. Fu, Z. Yang, X.M. Yin*, Measurement of the Activity of the Atg4 Cysteine Proteases, Methods Enzymol, 587 (2017) 207-225.

[6] Y. Gao, Y. Liu, L. Hong, Z. Yang, X. Cai, X. Chen, Y. Fu, Y. Lin, W. Wen, S. Li, X. Liu, H. Huang, A. Vogt, P. Liu*, X.M. Yin*, M. Li*, Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy, Cell Death Dis, 7 (2016) e2330.

[7] M. Zhang, W.S. Sun, G.M. Zhu, G.J. Bao, B.Z. Zhang, L. Hong*, M. Li*, R. Wang*, Enantioselective Dearomative Arylation of Isoquinolines, ACS Catal, 6 (2016) 5290-5294.

[8] J. Zhou, Z. Yang, F. Zhang, H.B. Luo, M. Li*, R. Wu*, A salt bridge turns off the foot-pocket in class-II HDACs, Phys Chem Chem Phys, 18 (2016) 21246-21250.

[9] M. Li*, Z. Yang, L.L. Vollmer, Y. Gao, Y. Fu, C. Liu, X. Chen, P. Liu, A. Vogt, X.M. Yin*, AMDE-1 is a dual function chemical for autophagy activation and inhibition, PLoS One, 10 (2015) e0122083.

[10] S. Gao, H. Li, Y. Cai, J.T. Ye, Z.P. Liu, J. Lu, X.Y. Huang, X.J. Feng, H. Gao, S.R. Chen, M. Li*, P.Q. Liu*, Mitochondrial binding of alpha-enolase stabilizes mitochondrial membrane: its role in doxorubicin-induced cardiomyocyte apoptosis, Arch Biochem Biophys, 542 (2014) 46-55.

[11] M. Li, B. Khambu, H. Zhang, J.H. Kang, X. Chen, D. Chen, L. Vollmer, P.Q. Liu, A. Vogt, X.M. Yin*, Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity, J Biol Chem, 288 (2013) 35769-35780.

[12] M. Li, X. Chen, Q.Z. Ye, A. Vogt, X.M. Yin*, A high-throughput FRET-based assay for determination of Atg4 activity, Autophagy, 8 (2012) 401-412.

[13] M. Li, Y.F. Hou, J.S. Wang, X.Y. Chen, Z.M. Shao, X.M. Yin*, Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates, J Biol Chem, 286 (2011) 7327-7338.

 

其他文章:

[1] Y. Liao, M. Li, X. Chen, Y. Jiang, X.M. Yin*, Interaction of TBC1D9B with Mammalian ATG8 Homologues Regulates Autophagic Flux, Sci Rep, 8 (2018) 13496

[2] X. Zhang, C. Wang, J. Wu, Y. Liu, Z. Yang, Y. Zhang, X. Sui, M. Li, M. Feng*, An acid-seeking carrier-free drug achieves high antitumor activity via a "solution-particle" transition, J Control Release, 262 (2017) 305-316.

[3] G. Xiang, L. Yang, Q. Long, K. Chen, H. Tang, Y. Wu, Z. Liu, Y. Zhou, J. Qi, L. Zheng, W. Liu, Z. Ying, W. Fan, H. Shi, H. Li, X. Lin, M. Gao, J. Liu, F. Bao, L. Li, L. Duan, M. Li, X. Liu*, BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, Autophagy, 13 (2017) 1543-1555.

[4] M. Luo, Q. Liu, M. He, Z. Yu, R. Pi, M. Li, X. Yang, S. Wang, A. Liu*, Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells, J Cell Mol Med, 21 (2017) 46-57.

[5] J. Lu, D.P. Sun, Z.P. Liu, M. Li, H.Q. Hong, C. Liu, S. Gao, H. Li, Y. Cai, S.R. Chen, Z.M. Li, J.T. Ye*, P.Q. Liu*, SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy, Translational Research, 172 (2016) 96-112.

[6] S.L. Liu, S.R. Chen, M. Li, B.Y. Zhang, P.Y. Shen, P.Q. Liu, D.D. Zheng, Y.J. Chen, J.M. Jiang*, Autophagy activation attenuates angiotensin II-induced cardiac fibrosis, Arch Biochem Biophys, 590 (2016) 37-47.

[7] S. Gao, H. Li, X.J. Feng, M. Li, Z.P. Liu, Y. Cai, J. Lu, X.Y. Huang, J.J. Wang, Q. Li, S.R. Chen, J.T. Ye*, P.Q. Liu*, alpha-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction, J Mol Cell Cardiol, 79 (2015) 92-103.

[8] J. Zhou, M. Li, N. Chen, S. Wang, H.B. Luo, Y. Zhang, R. Wu*, Computational design of a time-dependent histone deacetylase 2 selective inhibitor, ACS Chem Biol, 10 (2015) 687-692.

[9] H. Gao, X.J. Peng, Z.M. Li, M. Li, S. Gao, Y.H. He, J.J. Wang, S.Y. Zeng, X.P. Liu, X.Y. Huang, S.R. Chen, P.Q. Liu*, Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides, Arch Biochem Biophys, 565 (2015) 76-88.

[10] L.I. Gallo, Y. Liao, W.G. Ruiz, D.R. Clayton, M. Li, Y.J. Liu, Y. Jiang, M. Fukuda, G. Apodaca*, X.M. Yin*, TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells, Molecular Biology of the Cell, 25 (2014) 3779-3797.

[11] D. Akin, S.K. Wang, P. Habibzadegah-Tari, B. Law, D. Ostrov, M. Li, X.M. Yin, J.S. Kim, N. Horenstein, W.A. Dunn*, A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors, Autophagy, 10 (2014) 2021-2035.

[12] L. Zhang, Y. Chen, Z. Yue, Y. He, J. Zou, S. Chen, M. Liu, X. Chen, Z. Liu, X. Liu, X. Feng, M. Li, P. Liu*, The p65 subunit of NF-kappaB involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes, Arch Biochem Biophys, 554 (2014) 22-27.

[13] X. Chen, B. Khambu, H. Zhang, W. Gao, M. Li, X. Chen, T. Yoshimori, X.M. Yin*, Autophagy induced by calcium phosphate precipitates targets damaged endosomes, J Biol Chem, 289 (2014) 11162-11174.

[14] C.W. Lin, H. Zhang, M. Li, X. Xiong, X. Chen, X. Chen, X.C. Dong, X.M. Yin*, Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice, J Hepatol, 58 (2013) 993-999.

[15] D. Chen, X. Chen, M. Li, H. Zhang, W.X. Ding, X.M. Yin*, CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable, Biochem Biophys Res Commun, 432 (2013) 226-230.

[16] X. Chen, M. Li, D. Chen, W. Gao, J.L. Guan, M. Komatsu, X.M. Yin*, Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis, PLoS One, 7 (2012) e52347.

[17] W.X. Ding, M. Li, J.M. Biazik, D.G. Morgan, F.L. Guo, H.M. Ni, M. Goheen, E.L. Eskelinen, X.M. Yin*, Electron Microscopic Analysis of a Spherical Mitochondrial Structure, J Biol Chem, 287 (2012) 42373-42378.

[18] J.H. Kang, M. Li, X. Chen, X.M. Yin*, Proteomics analysis of starved cells revealed Annexin A1 as an important regulator of autophagic degradation, Biochem Biophys Res Commun, 407 (2011) 581-586.

[19] W.X. Ding, M. Li, X.M. Yin*, Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets, Autophagy, 7 (2011) 248-249.

[20] W.X. Ding, M. Li, X.Y. Chen, H.M. Ni, C.W. Lin, W.T. Gao, B.F. Lu, D.B. Stolz, D.L. Clemens, X.M. Yin*, Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice, Gastroenterology, 139 (2010) 1740-1752.

[21] H.M. Ni, C.J. Baty, N. Li, W.X. Ding, W. Gao, M. Li, X. Chen, J. Ma, G.K. Michalopoulos, X.M. Yin*, Bid Agonist Regulates Murine Hepatocyte Proliferation by Controlling Endoplasmic Reticulum Calcium Homeostasis, Hepatology, 52 (2010) 338-348.

[22] W.X. Ding, H.M. Ni, M. Li, Y. Liao, X.Y. Chen, D.B. Stolz, G.W. Dorn, X.M. Yin*, Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming, J Biol Chem, 285 (2010) 27879-27890.

 

其他

本课题组招收特聘研究员、副研究员及博士后人员,欢迎对自噬发生机制、自噬在疾病调控中的作用、新药筛选等方向感兴趣。直接联系本人。

欢迎研究生报考!