联系方式

办公电话:020-39943034-808

电子邮箱:jinjing@mail.sysu.edu.cn

办公地址:广州大学城外环东路132号中山大学药学院,510006

 

简单介绍

金晶,女,中山大学药学院副教授,"广东省特支计划”百千万工程青年拔尖人才,中国药理学会青年药理学家奖获得者。2001年本科毕业于华中科技大学同济医学院,后在该校继续深造,2004年获得硕士学位。2010年6月毕业于中山大学药学院,获药理学博士学位。2004年7月于中山大学药学院工作,历任助教、讲师,副教授。主要从事药物代谢与药理毒理学方面的研究。近年来,在国内外重要学术期刊杂志上发表SCI收录论文40余篇,以第一作者/通讯作者发表SCI收录期刊论文20余篇。主持包括国家自然科学基金在内的多项国家和省局级课题。参加国际性学术会议并做口头汇报多次,任国家自然科学基金同行评审专家、多种国际学术期刊特邀审稿人和中国药理学会会员。

 

研究方向

1.      药物的代谢处置与毒性过程及相关调控机制

2.      中药/药物相互作用的基础与临床研究

 

教育经历

1997. 09~2001, 06   华中科技大学同济医学院   学士学位
2001. 09~2004. 06   华中科技大学同济医学院   硕士学位
2007. 09~2010. 06   中山大学药学院          博士学位

 

工作经历

2004. 07-今,中山大学,历任助教、讲师、副教授

 

科研项目

1.     国家自然科学基金,面上项目:基于Nrf2介导的细胞代谢重编程探讨隐丹参酮逆转NSCLC顺铂获得性耐药的作用机制,编号:81573658,2016/01-2019/12

2.     国家自然科学基金,青年基金:Nrf2/ARE防御系统在雷公藤肝毒性中的作用及机制研究, 编号:81102886,2012/01-2014/12

3.     中山大学青年教师培育计划,PXR基因多态性与缺血性脑卒中患者氯吡格雷用药个体反应差异及机制研究,2016/01-2018/12

4.     广东省医学科研基金:血液microRNA作为预警丙戊酸肝毒性的生物标志物研究, 编号:B2012077,2012/6-2015.6

5.     广东省中医药局科研基金:基于Nrf2-Keap1调控网络的甘草与有毒中药配伍减毒作用及分子机制研究,编号:20141051,2015/01-2016/12

6.     国家自然科学基金,面上项目:基于“结构-代谢-活性”关联的冬青属三萜皂苷抗血栓效应成分研究,编号:81270054,2013/01-2016/12,合作单位负责人

7.     广州市珠江科技新星项目协作课题,基于胃肠道生物转化的冬青属三萜皂苷降解产物及其抗血栓活性研究,编号:2011J2200047,,2013/01-2013/12

 

论著专利

1.         Bai XP, Hong WP, Cai PH, Chen YB, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Toxicology and Applied Pharmacology2017, 324(6): 12-25.

2.         Bai XP, Chen YB, Hou XY, Huang M*, Jin J*. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metabolism Reviews. 2016, 48(4):541-567

3.         Xia C, Bai XP, Hou XY, Gou XL Wang YT, Zeng H, Huang M, Jin J*. Cryptotanshinone reverses cisplatin resistance of human lung carcinoma A549 cells through down-regulating Nrf2 pathway, Cellular Physiology and Biochemisty2015, 37:816-824.

4.         Hou XY, Bai XP, Gou XL, Zeng H, Xia C, Zhuang W, Chen XM, Zhao ZX, Huang M, Jin J*. 3',4',5',5,7-Pentamethoxyflavone sensitizes cisplatin-resistant A549 cells to cisplatin by inhibition of Nrf2 pathway, Molecules and Cells2015, 38(5): 396-401.

5.         Liu B, Gou XL, Bai XP, Hou XY, Li DS, Zhong GP, Jin J*, Huang M*. Simultaneous determination of seven taxoids in rat plasma by UPLC–MS/MS and pharmacokinetic study after oral administrationof Taxus yunnanensis extracts, Journal of Pharmaceutical and Biomedical Analysis2015, 107: 346-354.

6.         Liu R, Zhou ZY, Chen YB, Li JL, Yu WB, Chen XM, Zhao M, Zhao YQ, Cai YF,Jin J*, Huang M*. Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke. Acta Pharmacologica Sinica. 2016, 37(7): 882-888

7.         Wang WW, Guan CW, Sun XZ, Zhao ZX, Li J, Fu XL, Qiu YW, Huang M, Jin J*, Huang ZY*. Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine  2016,23:589-596

8.         Chen XM, Zhao ZX, Chen YB, Gou XL, Zhou ZY, Zhong GP, Cai YF, Huang M, Jin J*.Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology. 2016, 192:362-369.

9.         Qiu MS, Cao D, Gao YH, Li SH, Zhu JP, Yang B, Zhou L, Zhou Y, Jin J *, Zhao ZX *, New clerodane diterpenoids from Croton crassifolius, Fitoterapia,2016, 108: 81–86.

10.     Jin J, Sun XZ, Zhao ZX, Wang WW, Qiu YW, Fu XL, Huang M, Huang ZY*. Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity. Phytomedicine2015, 22(10):894-901.

11.     Jin J, Li M., Wang WW, Sun XZ, Li J, Zhao ZX, Huang M, Huang ZY*. Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine, 2015, 22(5):528-535.

12.     Jin J*, Xiong TQ, Hou XY, Sun XZ, Liao JY, Huang ZY, Huang M, Zhao ZX*. Role of Nrf2 activation and NF-kappaB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice. Food and Chemical Toxicology2014,73: 95-104.

13.     Jin J, Cai DK, Bi HC, Zhong GP, Zeng H, Gu LQ, Huang ZY, Huang M*. Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats. Fitoterapia2013,90: 1-9.

14.     Jin J, Bi H, Hu J, Zeng H, Zhong G, Zhao L, Huang Z, Huang M*. Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of paclitaxel in rats. Phytotherapy Research2011,25(8): 1250-1253.

15.     Jin J, Liu J, Chen JY, Zhao LZ, Ma Z, Chen X, Huang M, Zhong GP*. Bioequivalence evaluation of two tablet formulations of entecavir in healthy chinese volunteers: a single-dose, randomized-sequence, open-label crossover study. Arzneimittelforschung/Drug Research2012,62(3): 113-116.

16.     Jin J, Bi HC, Hu JQ, Zhong GP, Zhao LZ, Huang ZY, Huang M*. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharmceutics & Drug Disposition2010, 31(4):264-268.

17.     Chen XM, Jin J*, Chen YB, Peng LL, Zhong GP, Li JL, Bi HC, Cai YF, Huang M*. Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. Biopharmceutics & Drug Disposition2015,36(1): 64-68.

18.     Fan Z, Zhou L, Xiong TQ, Zhou J S, Li QG, Tan QL, Zhao ZX*, Jin J*. Antiplatelet aggregation triterpene saponins from the barks of Ilex rotunda.Fitoterapia2015,101: 19-26.

19.    Fan Z#Jin J#, Lin CZ, Zhu CC, Yang T, Yang B, Zhu JP, Zhao ZX*. New Flavanol Glucosides from Abacopteris aspera (PRESL) CHING. Helvetica Chimica Acta2015,98(1): 108-115.

20.     Yang B, Yang T, Tan Q, Zhu J, Zhou L, Xiong T, Zhao Z*, Jin J*. Antiplatelet aggregation triterpene saponins from the leaves of Ilex kudingcha.Phytochemistry Letters2015,13: 302-307.

21.     Li J, Shen FH, Guan CW, Wang WW, Sun XZ, Fu XL, Huang M, Jin J*, Huang ZY*. Activation of Nrf2 protects against triptolide-induced hepatotoxicity.PLoS One2014,9(7): e100685.

22.     Li J, Jin J*, Li M, Guan CW, Wang WW, Zhu SH, Qiu YW, Huang M, Huang ZY*. Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells. Toxicology Letters2012, 213(2): 194-202.

23.     Zhu SH, Wang Y, Jin J*, Guan CW, Li M, Xi C, Ouyang ZZ, Chen MW, Qiu YW, Huang M, Huang ZY*. Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells. Toxicology In Vitro2012,26(5): 663-671.

24.   Zhu SH, Jin J*, Wang Y, Ouyang ZZ, Xi C, Li J, Qiu YW, Wan JZ, Huang M,Huang ZY*. The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells. Food and Chemical Toxicology2012,50(3-4): 1149-1158.

 

获奖情况

1. 2016年获中国药理学会青年药理学家奖

2. 2015年获《Food and Chemical Toxicology》杂志杰出审稿人奖,Certificate of Outstanding Contribution in Reviewing

3. 2011年获国际/中国药物代谢专业委员会,Best Presentation Award

4. 2011年获第十八届微粒体与药物代谢国际会议,中国青年科学家Travel Award