简单介绍

顾琼,女,博士,副教授,博士生导师

工作经历

2015/1 - 至今,中山大学 药学院,副教授
2014/8- 2015/8,美国北卡罗来纳大学教堂山分校 访问学者
2010/3 - 2014/12,中山大学 药学院,讲师
2007/7-2009/12,中山大学,药学院,博士后
2001/9 - 2007/3,中科院昆明植物研究所,天然药物化学,博士

科研项目

1、国家高新技术发展计划(863计划), 2012AA020304, 基于中西药学融合的靶向发现与药物分子设计技术,2012/01-2015/12,290万,项目负责人。
2、国家自然科学基金面上基金项目, 81573310, 基于倍半萜内酯片段重组的抗骨质疏松先导化合物的发现、优化和机理研究,2016/01-2019/12, 60万, 项目负责人。 
3、国家自然科学基金青年基金项目, 81001372, 基于结构片段从天然产物库中筛选以Aß为靶点抗老年痴呆先导化合物,2010/01-2013/12, 20万, 已结题,项目负责人。
4、广东省科技计划项目,基于天然产物片段发现与组装的先导化合物骨架创新技术,2016A020217005,2016/01-2018/12,30万元,项目负责人
5、中科院昆明植物所植物化学与西部植物资源持续利用国家重点实验室开放基金,P2010-KF08,两种菊科植物的化学成分与抗乙肝病毒活性研究,2011/01-2012/12,8万,已结题,项目负责人。 
6、企业合作,银蓝调脂胶囊组方药材化学组分的提取,2014/01-2014/10,10万,已结题,项目负责人。
7、企业合作,降血脂,抗衰老,抗炎,抗病毒的药物先导化合物筛选研究,2011/10-2014/10,5万,已结题,项目负责人。

论著专利

近五年已发表论文:(*通讯作者)
1.    Cheng Jiang, Pan Luo, Jialing Hong, Susan L. Morris-Natschke, Jun Xu, Chin-Ho Chen, Kuo-Hsiung Lee,* Qiong Gu.* Carolignans from the aerial parts of Euphorbia sikkimensis and their anti-HIV activity. J Nat Prod, 2016,79: 578-583.
2.    Taizong Wu,# Cheng Jiang,# Ling Wang, Susan L. Morris-Natschke, Hui Miao, Lianquan Gu, Jun Xu, Kuo-Hsiung Lee,* Qiong Gu.* neo-Clerodane Diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. J Nat Prod, 2015, 78 (3): 500-509.
3.    Taizong Wu,# Qian Wang,# Cheng Jiang, Susan L. Morris-Natschke, Hui Cui, Yan Wang, Yan Yuan, Jun Xu, Kuo-Hsiung Lee,* Qiong Gu.* 3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer’s Disease. J Nat Prod, 2015, 78: 1593-1599.
4.    Fang Sai, Lei Chen, Miao Yu, Bao Cheng, Yongsheng Lin, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Qiong Gu,* Jun Xu.* Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives. Organic & Biomolecular Chemistry, 2015, 13: 4714-4726. 
5.    Yali Li, Ling Wang, Zhihong Liu, Chanjuan Li, Jiake Xu, Qiong Gu,* Jun Xu.* Predicting selective liver X receptor β agonists using multiple machine learning methods. MolecularBioSystems, 2015, 11 (5): 1241-1250.
6.    Xiu Le, Qing Gu*, Jun Xu*. Identifying MurI uncompetitive inhibitors by correlating decomposed binding energies with bioactivity. RSC Adv., 2015, 5:40536-40545.
7.    L. Wang,* R.R. Zeng, X.Q. Pang, Q. Gu,* W. Tan.* The mechanisms of flavonoids inhibiting conformational transition of amyloid-β42  monomer: a comparative molecular dynamics simulation study. RSC Adv, 2015, 5, 66391.
8.    Qianzhi Ding, Chanjuan Li, Ling Wang, Yali Li, Huihao Zhou, Qiong Gu*, Jun Xu*. Identifying farnesoid X receptor agonists by naive Bayesian and recursive partitioning approaches. MedChemComm, 2015, 6, 1393-1403.
9.    Ling wang, Xiu Le, Long Li, Yingchen Ju, Zhongxiang Lin, Qiong Gu*, Jun Xu*. Discovering new agents active against methicillin-resistant Staphylococcus aureus with ligand-based approaches. J Chem Inf Model, 2014, 54, 3186-3197.
10.    Yingying Cao, Ling Wang, Zhongxiang Lin, Fengyin Liang, Zhong Pei, Jun Xu, Qiong Gu*. Dehydroabietylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease. MedChemComm, 2014, 5, 1736-1743. 
11.    Chanjuan Li, Hu Ge, Lujia Cui, Yali Li, Bao Cheng, Guodong Zhang, Ziying Zhang, Hao Qi, Yan Ruan, Qiong Gu, * Jun Xu*. Molecular mechanism of action of K (D) PT as an IL-1RI antagonist for the treatment of rhinitis. RSC Adv, 2014, 4:48741-48749. 
12.    Ling Wang, Lei Chen, Zhihong Liu, Minghao Zheng, Qiong Gu*, Jun Xu*. Predicting mTOR Inhibitors with a Classifier Using Recursive Partitioning and Naïve Bayesian Approaches. Plos one, 2014, 9 (5): e95221. 
13.    Lei Chen, Ling Wang, Qiong Gu*, Jun Xu*. An in silico protocol for identifying mTOR inhibitors from natural products. Mol Divers, 2014, 18: 841-852. 
14.    Qiong Gu*, Yaoyao Chen, Hui Cui, Dane Huang, Jingwei Zhou, Taizong Wu, Yiping Chen, Lina Shi and Jun Xu. Chrysanolide A, an unprecedented sesquiterpenoid trimer from the flowers of Chrysanthemum indicum L. RSC Adv, 2013, 3, 10168-10172. 
15.    Qiong Gu, Xin Yan, Jun Xu. Drug discovery inspired by mother nature: seeking natural biochemotypes and the natural assembly rules of the biochemome. J Pharm Pharm Sci, 2013, 16 (2): 331-341.
16.    Qiong Gu, Yanping Li, Yingchun Chen, Peifen Yao, Tianmiao Ou. Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease. Natural Product Research, 2013, 27 (22):2157-2160. 
17.    Yingying Cao, Ling Wang, Hu Ge, Xilin Lu, Zhong Pei, Qiong Gu*, Jun Xu. Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease. Mol Divers, 2013, 17:515-524. 
18.    Taizong Wu, Hui Cui, Bao Cheng, Sai Fang, Jun Xu, Qiong Gu*. Chemical constituents from the roots of Elephantopus scaber L. Biochemical Systematics and Ecology. 2014, 54:65-67.
19.    Ling Wang, Qiong Gu*, Xuehua zheng, Jiming Ye, Zhihong Liu, Jiabo Li, Xiaopeng Hu, Arnold Hagler*, Jun Xu*. Discovery of new selective human aldose reductase inhibitors through virtual screening multiple binding pocket conformations. J. Chem. Inf. Model., 2013, 53, 2409-2422. 
20.    Hui Cui,# Bo Xu,# Taizong Wu, Jun Xu, Yan Yuan*, Qiong Gu*. Potential Anti-viral Lignans from the Roots of Saururus chinensis with Activity against Epstein-Barr Virus Lytic Replication. J Nat Prod, 2013, 77, 100-110. 
21.    Minghao Zheng, Zhilong Liu, Xin Yan, Qianzhi Ding, Qiong Gu,* Jun Xu.* LBVS: an online platform for ligand-based virtual screening using publicly accessible databases. Mol Divers, 2014, 18:829-840. 
22.    Zhang guodong, Ge Hu, Gu Qiong*, Xu Jun*. Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands. Sci China Chem, 2013, 56 (10): 1402-1412. 
23.    Qiong Gu, Jun Xu, Lianquan Gu. Selecting diversified compounds to build tanglible library for biological and biochemical assay. Molecules, 2010, 15 (7): 5031-5044. 

专利:
1.  顾琼,李艳萍,古练权,黄志纾,欧田苗. 3’,8”-双芹菜素型双黄酮类化合物在制备预防及治疗老年性痴呆药物中的应用.专利号:CN101712670 B(已授权)
2.    顾琼,曹影影,王领,徐峻,巫瑞波.丹酚酸A用于制备防治老年痴呆症药物的应用.申请号:CN201310196330.8
3.    顾琼,崔辉,徐峻,徐波,袁岩.一种三白草提取物及其制备方法和应用.专号:ZL 2013 1 0475808.0 (已授权)
4.    顾琼,吴泰宗,袁岩,王倩,徐峻,王彦.一种半枝莲提取物及其制备方法和应用, 申请号:201410566949.8
5.    顾琼,吴泰宗,袁岩,王倩,徐峻,王彦.一种半枝莲提取物及其制备方法和应用, 申请号:201410566948.3
6.    顾琼,吴泰宗,徐峻. 一类具有抗老年痴呆活性的吡唑类化合物、制备方法与应用,申请号:201410652725.9