简单介绍

黎星术,男,1954年生。四川师范大学化学系毕业;四川大学工学硕士,理学博士。1997 年起在香港理工大学, 台湾中兴大学, 日本岗山理科大学任博士后研究员, 研究员(Research Fellow)多年. 2005年到中山大学工作,教授, 博士生导师。2005年至今起被聘为香港理工大学荣誉研究员。

研究方向

主要研究方向:
1.手性配体的设计合成及在不对称合成,药物合成中的应用研究.
2.多靶点抗老年痴呆药物的设计、合成和生物活性研究
3. 多靶点抗哮喘、慢性阻塞性肺病药物的设计、合成和生物活性研究

负责的研究课题:
1. 国家自然科学基金课题(2项,22万,35万);
2. 国家863课题(分课题,8万);
3. 中山大学引进人才科研启动基金(50万);
4. 广东省自然科学基金 (6万);
5. 广州市科技攻关项目(30万);
6. 广东一力药物集团公司合作项目(100万);
7. 广东理文化工研发有限公司合作研究项目(175万)。

教学情况

1.有机化学
2.高等有机化学与药物合成
3.有机化学药物化学进展(讲座)

论著专利

近3年发表的部分文章:
1. Wu, Yinuo; Mao, Fei; Meng, Fanchao; Li, Xing-Shu*. Enantioselective Vanadium-Catalyzed Oxidation of 1,3-Dithianes from Aldehydes and Ketones using β-Amino Alcohol Derived Schiff Base Ligands.Advanced Synthesis & Catalysis (2011),353(10),1707-1712.
2. Wu, Yinuo; Li, Baozhu; Mao, Fei; Li, Xing-Shu*; Kwong, Fuk Yee.   Palladium-Catalyzed Oxidative C-H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides. Organic Letters (2011), 13(12), 3258-3261.
3. Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Jiang, Huai-Lei; Luo, Zong-Hua; Lai, Ke-fang; Li, Xing-Shu*. Dual β 2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD. Bioorganic & Medicinal Chemistry Letters (2012), 22(4), 523-1526.
4. Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu*. Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-βaggregation. European Journal of Medicinal Chemistry (2011), 46(12), 5885-5893.
5. Jiang, Huailei; Wang, Xu; Huang, Ling; Luo, Zonghua; Su, Tao; Ding, Ke; Li, Xingshu*.Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer's disease. Bioorganic & Medicinal Chemistry (2011), 19(23), 7228-7235.
6. Shi, Anding; Huang, Ling; Lu, Chuanjun; He, Feng; Li, Xing-Shu*. Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. Bioorganic & Medicinal Chemistry (2011), 19(7), 2298-2305.
7. Huang, Ling; Luo, Zonghua; He, Feng; Shi, Anding; Qin, Fangfei; Li, Xing-Shu*.Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters (2010),  20(22), 6649-6652.
8. Huang, Ling; Luo, Zonghua; He, Feng; Lu, Jing; Li, Xing-Shu*. Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic & Medicinal Chemistry  (2010), 18(12), 4475-4484.
9. Huang, Xiaoguang; Zhang, Aiqin; Chen, Dongliang; Jia, Zhenhua; Li, Xing-Shu*.4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: Novel C7 moieties of fluoroquinolones as antibacterial agents. 10. Huang, Ling; Shi, Anding; He, Feng; Li,Xing-Shu*. Synthesis,biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.    Bioorganic & Medicinal Chemistry (2010), 18(3), 1244-1251.
11. Huang, Xiaoguang; Chen, Dongliang; Wu, Ning; Zhang, Aiqin; Jia, Zhenhua; Li, Xingshu*.The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents. Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4130-4133.
12. Wu, Yinuo; Liu, Juntao; Li, Xing-Shu*; Chan, Albert S. C. Vanadium-Catalyzed Asymmetric Oxidation of Sulfides Using Schiff Base Ligands Derived from β-Amino Alcohols with Two Stereogenic Centers. European Journal of Organic Chemistry (2009),(16),  2607-2610.
13. Lu, Chuanjun; Luo, Zonghua; Huang, Ling; Li, Xing-Shu*. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry (2011), 22(7), 722-727.
14. Shan, Wenjun; Meng, Fanchao; Wu, Yinuo; Mao, Fei; Li, Xing-Shu*. The synthesis of a new nitrogen joined N-PEG-TsDPEN ligand and its application in asymmetric transfer hydrogenation of ketones in neat water. Journal of Organometallic Chemistry (2011), 696(8),  1687-1690.
15. Wei, Hui; Yin, Lu; Luo, Haibin; Li, Xing-Shu*; Chan, Albert S. C. Structural influence of chiral tertiary aminonaphthol ligands on the asymmetric phenyl transfer to aromatic aldehydes. Chirality (2011), 23(3), 222-227.
16. Yin, Lu; Zheng, Yourou; Jia, Xian; Li, Xingshu*; Chan, Albert S. C. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts.  Tetrahedron: Asymmetry (2010), 21(19), 2390-2393.
17. Huang, Ling; Liu, Juntao; Shan, Wenjun; Liu, Bao; Shi, Anding; Li, Xingshu*. The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with polyethylene glycol bound Rh catalyst in PEG2000 and water. Chirality (2010), 22(2), 206-211.
18. Yin, Lu; Jia, Xian; Li, Xingshu*; Chan, Albert S. C. A rapid and green approach to chiral α-hydroxy esters: asymmetric transfer hydrogenation (ATH) of α-keto esters in water by use of surfactants. Tetrahedron: Asymmetry (2009), 20(17), 2033-2037.
19. Chen, Xueming; Wei, Hui; Chen, Yunyun; Li, Xingshu*. A Convenient synthesis of imidazolidin-4-ones via Domino reactions. Helvetica Chimica Acta (2009), 92(8), 1550-1557.
20. Yin, Lu; Shan, Wenjun; Jia, Xian; Li, Xingshu*; Chan, Albert S. C. Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel. Journal of Organometallic Chemistry (2009), 694(13),  2092-2095.
21. Wu, Yinuo; Lu, Chuanjun; Shan, Wenjun; Li, Xingshu*. A practical process to chiral ferrocenyl alcohols via asymmetric transfer hydrogenation catalyzed with a PEG-bound Ru catalyst in water and its application in preparing Ugi's amine. Tetrahedron: Asymmetry (2009),  20(5), 584-587.
22. Liu, Bao; Zhong, Yao; Li, Xingshu*. Enantioselective addition of phenylacetylene to N-aryl arylimines catalyzed by Cu(II)-pyridine containing N-tosylated aminoimine ligand complex. Chirality (2009), 21(6), 595-599.
23. Chen, Xueming; Hou, Lei; Li, Xingshu*.  An easy one-pot synthesis of tetrasubstituted 3-alkynylpyrroles via multicomponent coupling reaction. Synlett  (2009), (5), 828-832.

获奖情况

1. 2005年国家自然科学二等奖;
2. 2004-2007年国际重要刊物Tetrahedron: Asymmetry最高引用率奖。