简单介绍

翁江,男,1982年11月生,博士,副教授,硕士生导师。主要研究方向为不对称合成、手型药物及活性天然产物的合成等。

教育经历

2010/07 – 2012/07,中山大学药学博士后流动站,博士后

2007/09 – 2010/06,中山大学药学院,有机化学专业,博士

2005/09 – 2007/06,中山大学化工学院,有机化学专业,硕士

2001/09 – 2005/06,湖北大学化材学院,应用化学专业,学士

工作经历

2017/1-至今,中山大学药学院,副教授

2012/08-2016/12,中山大学药学院,讲师

教学情况

有机化学;有机化学实验

科研项目

近年主持的纵向科研项目:

1. 国家自然科学基金-青年科学基金项目:环戊烯酮类前列腺素的合成新方法及其靶向白血病干细胞活性研究;21502240;2016.1-2018.12;

2. 广东省自然科学基金项目-自由申请项目:基于有机催化串联反应构建环状DPP-4抑制剂及其降血糖活性研究;2015A030313130;2015.8.1-2018.8.1;

3. 广东省自然科学基金项目-博士启动项目:有机催化串联Michael/Wittig/Aldol反应及其在前列腺素合成中的应用;S2013040012409;2013.10-2015.10;

4. 广东省医学科学基金项目:前列腺素F的高效合成新方法研究;A2015167;2015.7-2017.6;

5. 中央高校基本科研业务费-中山大学青年教师培育计划项目:2012.11-2015.11;

6. 中山大学青年教师起步资助计划;2012.12-2013.12

 

论著专利

发表论文:

1. Jun-Ming Li, Yong-Heng Wang, Yang Yu, Ruibo Wu, Jiang Weng,* Gui Lu.* Copper-catalyzed remote C–H functionalizations of naphthylamides through coordinating activation strategy and single-electron-transfer (SET) mechanism. ACS Catalysis20177, 2661-2667.

2. Jiang Weng,* Sheng Wang, Lin-Jie Huang , Zhang-Yi Luo, Gui Lu.*  Stereoselective Synthesis of Epoxyisoprostanes: An Organocatalytic and "Pot-economy" Approach. Chem. Commun201551, 10170-10173. (Highlighted by Organic Chemistry Portal)

3. Lin-Jie Huang, Jiang Weng,* Sheng Wang, Gui Lu.* Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles. Adv. Synth. Catal. 2015357(5), 993-1003.  (Highlighted by X-MOL)

4. Jiang Weng, Jun-Ming Li, Feng-Quan Li, Zhi-Sheng Xie, Gui Lu.* Asymmetric domino nitro-Michael/Horner-Wadsworth-Emmons reaction for disubstituted cyclohexenecarboxylate annulation: efficient synthesis of DPP-4 inhibitor ABT-341 and influenza neuraminidase inhibitors. Adv. Synth. Catal.2012354, 1961-1970.

5. Jiang Weng, Yong-Bo Li, Rui-Bin Wang, Gui Lu. Organocatalytic Michael reaction of nitroenamines with aldehydes: efficient asymmetric synthesis of (−)-oseltamivir. ChemCatChem20124, 1007-1012. (Invited paper)

6. Jiang Weng, Yong-Bo Li, Rui-Bin Wang, Feng-Quan Li, Can Liu, Albert S. C. Chan, Gui Lu. A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate. J. Org. Chem., 201075, 3125-3128. (Highlighted by SYNFACTS, 2010, 8, 857) 

7. Wei-Jie Huang, Qing Chen, Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Yan-Shi Xiong, Jiang Weng*, Gui Lu* Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions. Org. Chem. Front.20174, 472-482.

8.  Can Liu, Jiang Weng*, Zi-Hui Lin, Wei-Jie Huang, Jing Guo, Lin-Jie Huang, Gui Lu*, Asymmetric synthesis of vicinal amino alcohols via organocatalytic sequential α-amination/Grignard addition reactions of aldehydes. Tetrahedron: Asymmetry201728, 41-46.

9. Jiang Weng, Lin-Jie Huang, Liang Long, Ling-Yi Xu, Gui Lu. Enantioselective synthesis of syn-2-amino-1,3-diols via organocatalytic sequential oxa-Michael/α-amination reactions of α,β-unsaturated aldehydes. Tetrahedron Lett., 2016, 57, 2554-2557. 

10. Jun-Ming Li, Jiang Weng,* Gui Lu, Albert S.C. Chan. Copper-catalyzed C5-regioselective C-H sulfonylation of 8-aminoquinoline amides with aryl sulfonyl chlorides. Tetrahedron Lett.201657, 2121-2124. 

11. Jing Guo, Jiang Weng,* Gong-Bin Huang,  Lin-Jie Huang, Albert S. C. Chan,  Gui Lu.* Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3'-biindoles. Tetrahedron Lett.201657, 5493-5496. 

12. Yi Chen, Hui Yan, Hui-Xuan Chen, Jiang Weng,* Gui. Lu.* An Improved and Efficient Process for the Preparation of (+)-Cloprostenol. Chirality 201527, 392-396. 

13. Jiang Weng, Hui-Bing Ai, Ren-Shi Luo, Gui Lu, Asymmetric Michael reaction of aldehydes with β-nitroalkenes catalyzed by pyrrolidine-camphor derived organocatalysts bearing hydrogen-bond donors. Chirality 201224, 271-275. 

14. Hui-Xuan Chen, Lin-Jie Huang, Jin-Biao Liu, Jiang Weng,* Gui Lu.* Synthesis of Terminal Vinylphosphonates Via DBU-Promoted Tandem Phospha-Michael/Elimination Reactions. PHOSPHORUS SULFUR2014189, 1858-1866.

15. Ji-Quan Zhang, Yong-Jie Luo, Yan-Shi Xiong, Yang Yu, Zheng-Chao Tu, Zi-Jie Long, Xiao-Ju Lai, Hui-Xuan Chen, Yu Luo, Jiang Weng, Gui Lu. Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors. J. Med. Chem. 2016, 59, 7268–7274. 

16. Jin-Biao Liu, Hui Yan, Hui-Xuan Chen, Yu Luo, Jiang Weng, Gui Lu. Palladium-catalyzed Suzuki cross-coupling of N'-tosyl arylhydrazines. Chem. Commun.201349, 5268-5270.

17 Ren-Shi Luo, Jiang Weng, Hui-Bing Ai, Gui Lu, Albert S. C. Chan, Highly efficient asymmetric Michael reaction of aldehydes to nitroalkenes with diphenylperhydroindolinol silyl ethers as organocatalysts. Adv. Synth. Catal.2010351, 2449-2459. 

18. Yong-Jie Luo, Hui-Xuan Chen, Jiang Weng, Gui Lu. Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase. Mar. Drugs 2016, 14, 118. 

19. Ji-Quan, Zhang, Gong-Bin Huang, Jiang Weng, Gui Lu, Albert S. C. Chan. Copper(II)-catalyzed coupling reaction: an efficient and regioselective approach to N',N'-diaryl acylhydrazines. Org. Biomol.Chem. 201513, 2055-2063. 

20. Jin-Biao Liu, Lin Nie, Hui Yan, Li-Hua Jiang, Jiang Weng, Gui Lu. Palladium-catalyzed reductive homocoupling of N'-tosyl aryl hydrazines. Org. Biomol.Chem. 201311, 8014-8017. 

21. Ya-Hui Feng, Ren-Shi Luo, Lin Nie, Jiang Weng, Gui Lu. Chiral diphenylperhydroindolinol silyl ether catalyzed domino oxa-Michael-aldol condensations for the asymmetric synthesis of benzopyrans. Tetrahedron: Asymmetry 201425, 523-528. 

22. Gong Chen, Jiang Weng, Zhan-Chao Zheng, Xin-Hai Zhu, Yao-Yao Cai, Ji-Wen Cai, Yi-Qian Wan, Pd/C-catalyzed cyanation of aryl halides in aqueous PEG. Eur. J. Org. Chem.2008, (20), 3524-3528. 

23. Can Liu, Zong-Liang Guo, Jiang Weng, Gui Lu, Albert S. C. Chan, Chiral 1,1'-binaphthylazepine-derived amino alcohol catalyzed asymmetric aryl transfer reactions with boroxine as aryl source. Chiralit201022, 159-164. 

24. Gong Chen, Jian-Wei Xie, Jiang Weng, Xin-Hai Zhu, Zhan-Chao Zheng, Ji-Wen Cai, Yi-Qian Wan, CuI/PPh3/PEG-water: An efficient catalytic system for cross-coupling reaction of aryl iodides and alkynesSynthetic Commun. 201141, 3123-3133. 

 

发明专利:

■  授权专利:

1. Process for the preparation of 1-nitro-4-oxobutanylamides. European Patent application, EP 11164806.9. Juraj Rehak, Gui Lu, Julius Durmis, Jiang Weng, Henrich Brath, Yong-Bo Li, Martin Hutka, Stefan Toma, Attila Latika. (欧洲发明专利)

2. 一种具有流感病毒神经胺酸酶抑制活性的环己烯衍生物的制备,中国发明专利。 201110257557.X. 发明人:鲁桂、黎逢权、翁江、李勇波

■  申请专利:

1. 一种3,3’-双 吲哚化合物的制备方法,中国发明专利。申请号:201610133055.9 发明人:翁江、鲁桂、郭靖

2. 一种醋酸阿比特龙酯的制备方法,中国发明专利。申请号:201410426938.X. 发明人:翁江、鲁桂、黄琳杰、王尧