简单介绍

 

谭嘉恒,男,1980年11月生,博士,副教授,博士生导师。研究方向为核酸化学生物学与核酸药物化学。

作为负责人先后主持3项国家自然科学基金,获广东省自然科学杰出青年基金及广东特支计划科技青年拔尖人才项目,共发表SCI论文100多篇,他引1600多次,获授权专利20项。其中,作为通讯作者在J. Am. Chem. Soc.Angew. Chem., Int. Ed.Nucleic Acids Res.J. Med. Chem.Chem. Commun.Biosens. Bioelectron.Anal. Chem.等知名学术期刊发表论文20多篇,研究结果多次被Chem. Rev.Chem. Soc. Rev.J. Am. Chem. Soc.Angew. Chem., Int. Ed.等期刊论文正面引用,部分探针被国际同行应用。在国内外重要学术会议上做学术报告10余次,现任Sci. Rep.杂志化学领域编委会成员,2017年获第二十届中国药学会-施维雅青年药物化学奖

教育经历

 

1999.09-2003.07 中山大学化学与化学工程学院,应用化学专业,获学士学位

2003.09-2008.07 中山大学药学院,药物化学专业,获博士学位

 

工作经历

2008年7月-至今 中山大学药学院

教学情况

生物有机化学;药物化学实验;药物发现中的关键技术

社会/学术任职

Scientific Reports杂志化学领域编委会成员

 

科研项目

 

项目负责人 

1. 靶向G-四链体新型荧光原位杂交探针的设计合成及其在RNA结构与功能研究中的应用,21672268,国家自然科学基金—面上项目,65万元

2. 应用多芳基取代咪唑类荧光探针研究癌基因启动子G-四链体作为转录调控元件的分子机制,21272291,国家自然科学基金—面上项目,80万元

3. rDNA G-四链体荧光探针在靶向抗肿瘤药物研发中的应用,2015A030306004,广东省自然科学基金项目—杰出青年科学基金,100万元

4. 特异性靶向识别端粒G-四链体DNA 的Isaidigotone衍生物:结构,结合模式与生物活性的关系,81001400, 国家自然科学基金—青年基金项目, 20万元

5. “广东特支计划”科技青年拔尖人才,2015TQ01R342,30万元

 

论著专利

1.   Chen, X.-C.; Chen, S.-B.; Dai, J.; Yuan, J.-H.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.* Tracking the dynamic folding and unfolding of RNA G-quadruplexes in live cells. Angewandte Chemie, International Edition 2018, 57, 4702-4706.

2.    Hu, M.-H.; Wang, Y.-Q.; Yu, Z.-Y.; Hu, L.-N.; Ou, T.-M.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.* Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex. Journal of Medicinal Chemistry 2018, 61, 2447-2459.

3.    Wang, Y.-Q.; Hu, M.-H.; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.* Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA. Sensors and Actuators, B: Chemical 2018, 266, 187-194.

4.    Che, T.; Chen, S.-B.; Tu, J.-L.; Wang, B.; Wang, Y.-Q.; Zhang, Y.; Wang, J.; Wang, Z.-Q.; Zhang, Z.-P.; Ou, T.-M.; Zhao, Y.; Tan, J.-H.*; Huang, Z.-S.* Discovery of novel schizocommunin derivatives as telomeric G-quadruplex ligands that trigger telomere dysfunction and the deoxyribonucleic acid (DNA) damage response. Journal of Medicinal Chemistry 2018, 61, 3436-3453.

5.    Chen, S.-B.; Liu, G.-C.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex. Journal of Molecular Structure 2018, 1154, 1-7.

6.    Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.* Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Research 2017, 45, 1606-1618.

7.    Wang, Y.-Q.; Huang, Z.-L.; Chen, S.-B.; Wang, C.-X.; Shan, C.; Yin, Q.-K.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.* Design, synthesis, and evaluation of new selective NM23-H2 binders as c-MYC transcription inhibitors via disruption of the NM23-H2/G-quadruplex interaction. Journal of Medicinal Chemistry 2017, 60, 6924-6941.

8.    Hu, M.-H.; Guo, R.-J.; Chen, S.-B.; Huang, Z.-S.; Tan, J.-H.* Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes.Dyes and Pigments 2017, 137, 191-199.

9.    Chen, S.-B.; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.*; Tan, J.-H.* Visualization of NRAS RNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe. Journal of the American Chemical Society 2016, 138, 10382-10385.

10.    Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole. Biosensors & Bioelectronics 2016, 83, 77-84.

11.    Guo, R.-J.; Yan, J.-W.; Chen, S.-B.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes. Dyes and Pigments 2016, 126, 76-85.

12.    Xiong, Y.-X.; Huang, Z.-S.; Tan, J.-H.* Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives. European Journal of Medicinal Chemistry 2015, 97, 538-551.

13.    Hu, M.-H.; Chen, X.; Chen, S.-B.; Ou, T.-M.; Yao, M.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology. Scientific Reports 2015, 5, 17202.

14.    Hu, M.-H.; Chen, S.-B.; Guo, R.-J.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.* Development of a highly sensitive fluorescent light-up probe for G-quadruplexes.Analyst 2015, 140, 4616-4625.

15.    Hou, J.-Q.; Chen, S.-B.; Zan, L.-P.; Ou, T.-M.; Tan, J.-H.*; Luyt, L. G.; Huang, Z.-S.* Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach. Chemical Communications 2015, 51, 198-201.

16.    Yan, J.-W.; Chen, S.-B.; Liu, H.-Y.; Ye, W.-J.; Ou, T.-M.; Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids. Chemical Communications 2014, 50, 6927-6930.

17.    Chen, S.-B.; Wu, W.-B.; Hu, M.-H.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.* Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes. Chemical Communications 2014, 50, 12173-12176.

18.    Wang, X.; Zhou, C.-X.; Yan, J.-W.; Hou, J.-Q.; Chen, S.-B.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* Synthesis and evaluation of quinazolone derivatives as a new class of c-KIT G-quadruplex binding ligands. ACS Medicinal Chemistry Letters 2013, 4, 909-914.

19.    Chen, S.-B.; Shi, Q.-X.; Peng, D.; Huang, S.-Y.; Ou, T.-M.; Li, D.; Tan, J.-H.*; Gu, L.-Q.; Huang, Z.-S. The role of positive charges on G-quadruplex binding small molecules: Learning from bisaryldiketene derivatives. Biochimica et Biophysica Acta, General Subjects 2013, 1830, 5006-5013.

20.    Yan, J.-W.; Ye, W.-J.; Chen, S.-B.; Wu, W.-B.; Hou, J.-Q.; Ou, T.-M.; Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton. Analytical Chemistry 2012, 84, 6288-6292.

21.    Yan, J.-W.; Li, Y.-P.; Ye, W.-J.; Chen, S.-B.; Hou, J.-Q.; Tan, J.-H.*; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation. Bioorganic & Medicinal Chemistry 2012, 20, 2527-2534.

22.    Chen, S.-Y.; Chen, Y.; Li, Y.-P.; Chen, S.-H.; Tan, J.-H.*; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.* Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry 2011, 19, 5596-5604.

23.    Chen, S.-B.; Tan, J.-H.*; Ou, T.-M.; Huang, S.-L.; An, L.-K.; Luo, H.-B.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand. Bioorganic & Medicinal Chemistry Letters 2011, 21, 1004-1009.

24.    An, Z.-Y.; Yan, Y.-Y.; Peng, D.; Ou, T.-M.; Tan, J.-H.*; Huang, S.-L.; An, L.-K.; Gu, L.-Q.; Huang, Z.-S.* Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities. European Journal of Medicinal Chemistry 2010, 45, 3895-3903.

25.    Tan, J.-H.; Ou, T.-M.; Hou, J.-Q.; Lu, Y.-J.; Huang, S.-L.; Luo, H.-B.; Wu, J.-Y.; Huang, Z.-S.*; Wong, K.-Y.; Gu, L.-Q.* Isaindigotone derivatives: A new class of highly selective ligands for telomeric G-quadruplex DNA. Journal of Medicinal Chemistry 2009, 52, 2825-2835.

26.    Tan, J.-H.; Gu, L.-Q.; Wu, J.-Y.* Design of selective G-quadruplex ligands as potential anticancer agents. Mini-Reviews in Medicinal Chemistry 2008, 8, 1163-1178.

27.    Tan, J.-H.; Lu, Y.-j.; Huang, Z.-S.; Gu, L.-Q.*; Wu, J.-Y.* Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin. European Journal of Medicinal Chemistry 2007, 42, 1169-1175.

28.    Tan, J. H.; Zhang, Q. X.; Huang, Z. S.; Chen, Y.; Wang, X. D.; Gu, L. Q.*; Wu, J. Y.* Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives. European Journal of Medicinal Chemistry 2006, 41, 1041-1047.

获奖情况

第二十届中国药学会-施维雅青年药物化学奖