简单介绍

周晖皓 博士,教授,博士生导师。入选千人计划青年人才项目,中山大学百人计划二期青年杰出人才项目,是广东省珠江人才计划引进创新创业团队核心成员。主要运用结构生物学、生物化学方法,研究蛋白质翻译等生命活动关键过程中的蛋白质的结构与功能,并针对这些蛋白质开展靶向药物设计研究。已在包括NatureScience在内的国际学术期刊发表了二十余篇SCI研究论文。

 

研究方向

药物靶标结构生物学

基于片段的药物发现

药物化学

 

教育经历

2003.09 - 2009.06: 理学博士,中国科学技术大学生命科学学院,导师:牛立文教授、滕脉坤教授

2001.09 - 2003.06: 工学双学士,中国科学技术大学计算机系

1999.09 - 2003.06: 理学学士,中国科学技术大学生命科学学院

 

工作经历

2015.01 - 至今    中山大学药学院教授

2009.09 - 2015.01  美国SCRIPPS研究所博士后,合作导师:Paul Schimmel教授、Xiang-Lei Yang教授

 

教学情况

主讲和参与教学的课程包括:

本科生课程:《结构生物学与药学研究》

        《生物化学》

        《生物化学与分子生物学实验》

研究生课程:《结构生物学》

 

科研项目

国家自然科学基金面上项目,81773636,课题负责人

广东省自然科学基金自由申请项目,2017A030313123,课题负责人

广东省引进创新创业团队,2016ZT06Y337,团队核心成员,子课题负责人

中山大学医科重大项目培育项目,36000-31650008,课题负责人

中山大学百人计划二期启动项目,36000-18811200,课题负责人

 

论著专利

研究论文:

  1. Yingchen Ju, Zhihong Liu, Zizhen Zhang, Lijun Duan, Qi Liu, Qiong Gu, Cheng Zhang, Jun Xu*, Huihao Zhou*, Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity, Sci Rep, 2017, 7, 13719.

  2. Xiaoling Xu, Huihao Zhou, Quansheng Zhou, Fei Hong, My-Nuong Vo, Wanqiang Niu, Zhiguo Wang, Xiaolin Xiong, Kanaha Nakamura, Keisuke Wakasugi, Paul Schimmel, Xiang-Lei Yang, An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function, RNA Biol, [Epub ahead of print]

  3. Jiewen Du, Xin Yan, Zhihong Liu, Lu Cui, Peng Ding, Xiaoqing Tan, Xiuming Li, Huihao Zhou, Qiong Gu, Jun Xu, cBinderDB: a covalent binding agent database, Bioinformatics, 2017, 33, 1258-1260.

  4. Yingchen Ju, Shuilong Tong, Yongxiang Gao, Wei Zhao, Qi Liu, Qiong Gu, Jun Xu, Liwen Niu*, Maikun Teng*, Huihao Zhou*, Crystal structure of a membrane-bound L-amino acid deaminase from Proteus vulgaris. J Struct Biol, 2016, 195, 306-315.

  5. Litao Sun, Ana Cristina Gomes, Weiwei He, Huihao Zhou, Xiaoyun Wang, David W. Pan, Paul Schimmel, Tao Pan, Xiang-Lei Yang, Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair, J Am Chem Soc, 2016, 138, 12948-12955.

  6. Zhihong Liu, Peng Ding, Xin Yan, Minghao Zheng, Huihao Zhou, Yuehua Xu, Yunfei Du, Qiong Gu, Jun Xu, ASDB: a resource for probing protein functions with small molecules. Bioinformatics, 2016, 32, 1752-1754.

  7. Gongrui Guo, Yongxiang Gao, Zhongliang Zhu, Debiao Zhao, Zhihong Liu, Huihao Zhou*, Liwen Niu*, Maikun Teng*, Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII, J Struct Biol, 2015, 192, 418-425.

  8. Weiwei He, Ge Bai, Huihao Zhou, Na Wei, Nicholas M. White, Janelle Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Albena Jordanova, Velina Guergueltcheva, Patrick R. Griffin, Robert W. Burgess, Samuel L. Pfaff, Xiang-Lei Yang, CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase, Nature, 2015, 526, 710-714.

  9. Long Li, Xiu Le, Ling Wang, Qiong Gu, Huihao Zhou, Jun Xu, Discovering new DNA gyrase inhibitors using machine learning approaches, RSC Adv, 2015, 5, 105600-105608.

  10. Jonathan D. Herman, Lauren R. Pepper, Joseph F. Cortese, Guillermina Estiu, Kevin Galinsky, Vanessa Zuzarte-Luis, Emily R. Derbyshire, Ulf Ribacke, Amanda K. Lukens, Sofia A. Santos, Vishal Patel, Clary B. Clish, William J. Sullivan Jr., Huihao Zhou, Selina E. Bopp, Paul Schimmel, Susan Lindquist, Jon Clardy, Maria M. Mota, Tracy L. Keller, Malcolm Whitman, Olaf Wiest, Dyann F. Wirth, Ralph Mazitschek1, The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med, 2015, 7, 288ra77.

  11. Qianzhi Ding, Chanjuan Li, Ling Wang, Yali Li, Huihao Zhou, Qiong Gua, Jun Xu, Identifying farnesoid X receptor agonists by naïve Bayesian and recursive partitioning approaches, MedChemComm, 2015, 6, 1393-1403.

  12. Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Huihao Zhou, Xiang-Lei Yang, Paul Schimmel, Satoru Senju, Yasuharu Nishimura, Jeffrey H. Chuang, Susan L. Ackerman1, Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science, 2014, 345, 455-459.

  13. Huihao Zhou, Litao Sun, Xiang-Lei Yang, Paul Schimmel, ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature, 2013, 494, 121-124.

  14. Huihao Zhou, Zhao Zha, Yang Liu, Hongtao Zhang, Juanjuan Zhu, Siyi Hu, Guodong Shen, Liansheng Cheng, Liwen Niu, Mark I. Greene, Maikun Teng, Jing Liu, Structural insight into the down-regulation of overexpressed p185(her2/neu) protein of transformed cells by the antibody chA21. J Biol Chem, 2011, 286, 31676-31683.

  15. Huihao Zhou, Qi Liu, Yongxiang Gao, Maikun Teng, Liwen Niu, Crystal structure of NusG N-terminal (NGN) domain from Methanocaldococcus jannaschii and its interaction with rpoE”. Proteins, 2009, 76, 784-793.

  16. Huihao Zhou, Qi Liu, Weili Yang, Yongxiang Gao, Maikun Teng, Liwen Niu, Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion. Proteins, 2009, 76, 512-515.

  17. Yang Liu, Huihao Zhou, Juanjuan Zhu, Yongxiang Gao, Liwen Niu, Jing Liu, Maikun Teng, Crystallization and preliminary crystallographic studies of the single-chain variable fragment of antibody chA21 in complex with an N-terminal fragment of ErbB2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65, 692-694.

  18. Shuilong Tong, Huihao Zhou, Yongxiang Gao, Zhiqiang Zhu, Xiao Zhang, Maikun Teng, Liwen Niu, Crystal structure of human osteoclast stimulating factor. Proteins, 2009, 75, 245-251.

  19. Yingji Cui, Heng Li, Xu Li, Yang Li, Huihao Zhou, Liwen Niua, Maikun Teng, Crystallization and preliminary crystallographic analysis of the second RRM of Pub1 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65, 108-110.

  20. Qi Liu, Yang Gao, Weili Yang, Huihao Zhou, Yongxiang Gao, Xiao Zhang, Maikun Teng, and Liwen Niu, Crystallization and preliminary crystallographic analysis of tRNA (m(7)G46) methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008, 64, 743-745.

 

专利申请:

  1. Xiang-Lei Yang, Na Wei, Huihao Zhou, Paul Schimmel. Binding activity of aminoacyl-tRNA synthetase in Charcot-Marie-Tooth (CMT) neuropathy and CMT-related neurological disease. International Publication Number: WO2017066482, 2017-04-20.  

  2. 刘兢,程联胜,刘洋,周晖皓,滕脉坤,朱娟娟,魏海明,肖卫华,“一种抗原-抗体复合物晶体及其制备方法与抗原表位”,中国发明专利公开号:CN101418047, 2011-04-20