药物化学

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袁燕秋 [副教授,博士生导师]

袁燕秋

联系方式

办公电话:

电子邮箱:yuanyq8@mail.sysu.edu.cn

办公地址:中山大学东校区药学院509

简单介绍

袁燕秋,女,博士,副教授,博士生导师,中山大学“百人计划二期”引进人才。

研究方向

从蛋白酶的动力学原理和对其三维结构的解析,研究跟疾病相关的分子靶标

针对新的靶点,基于高通量筛选的新药研发

教育经历

2008年,理学博士,化学与化学生物学系,美国马萨诸塞州哈佛大学,论文导师Suzanne Walker                                                

2003年,理学学士,应用化学系中国科学技大学

         



工作经历

2015年1月 - 20178   丹麦哥本哈根大学助理教授胞与分子医学系

20118 - 201412 诺华生物医学研究所Investigator II, 肿瘤部门,美国马萨诸塞州           

20088 - 20117诺华生物医学研究所Investigator, 遗传病部门,美国马萨诸塞州


科研项目

中山大学“百人计划二期”启动项目

论著专利

1.     Chen X, Giraldes J, Sprague ER, Shakya S, Chen Z, Wang Y, Joud C, Mathieu S, Chen CH, Straub C, Duca J, Hurov K, Yuan Y, Shao W, Touré BB. "Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors. J. Med. Chem., 2017, 60, 2155-2161.

2.     Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K, Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J. Med. Chem., 2016, 59, 4711-23. 

3.     Six DA, Yuan Y, Leeds JA, Meredith TC.  Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility. Antimicrob. Agents Chemother., 2014, 58, 153-161.

4.     Yuan Y, Sachdeva M, Leeds JA, Meredith TC.  Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases. J. Bacteriol., 2012, 194, 5171-5184.  

5.     Yuan Y, Leeds JA, Meredith TC.  Pseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesis. J. Bacteriol., 2012, 194, 5185-5196.

6.     Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D.  Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chemical Biology, 2010, 5, 701-11.

7.     Yuan Y, Fuse S, Sliz P, Kahne D, Walker S.  Structural and functional analysis of the H-bonding network that anchors moenomycin in the peptidoglycan glycosyltransferase active site: implications for antibiotic design. ACS Chemical Biology, 2008, 3, 429-436.

8.     Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S.  Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J. Biol. Chem., 2007, 208, 31964-31971.

9.     Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 5348-5453.

10.  Ginsberg C, Zhang YH, Yuan Y, Walker S.  In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis. ACS Chem. Biol., 2006, 1, 25-28.

11.  Zhang YH, Ginsberg C, Yuan Y, Walker S.  Substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Biochemistry, 2006, 45, 10895-10904.

12.  Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S.  In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J. Am. Chem. Soc., 2005, 127, 14128-14129.

13.  Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S.  Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. J. Am. Chem. Soc., 2004, 126, 7462-7463.