药物化学

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钱宇 [副教授,硕士生导师]

钱宇

联系方式

办公电话:

电子邮箱:qianyu5@mail.sysu.edu.cn

办公地址:广东省广州市广州大学城外环东路132号中山大学药学院320B

简单介绍

钱宇,博士,副教授,硕士研究生导师。2017年3月通过中山大学“百人计划”二期加入药学院

研究方向

不对称催化和杂环类化合物的高效合成方法学

抗感染领域的新药研究

制药工艺研究


教育经历

2011-2013 美国马里兰大学化学与生物化学系,有机化学专业,国家公派联合培养博士研究生,访问学者。

2007-2011 华东师范大学, 有机化学专业, 博士。

2003-2007 大连理工大学, 制药工程专业, 学士。


工作经历

2017-至今,中山大学,药学院,副教授

2016-2017,华东师范大学,化学与分子工程学院,专任副研究员

2013-2016,上海药明康德新药研发有限公司, 组长(高级研究员)


教学情况

主讲本科教学《基础化学》和《基础化学实验》

科研项目

中山大学“百人计划”二期启动项目

论著专利

(1) Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij, Wenhao Hu, Michael P. Doyle, “Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways”, Angew. Chem. Int. Ed. 2012, 51, 5900-5903.  Highlighted by Synfacts, 2012, 8, 0861. (IF = 13.455)

(2) Xichen Xu, Yu Qian, Peter Y. Zavalij, Michael P. Doyle, Selective catalyst-dependent competitive 1,2-CC, -OC and -NC migrations from β-methylene-β-silyloxy-β-amido-α-diazoacetates”, J. Am. Chem. Soc. 2013, 135, 1244−1247. (Joint first authors) (IF = 13.038)

(3) Yu Qian, Peter J. Zavalij, Wenhao Hu, Michael P. Doyle, “Bicyclic Pyrazolidinone Derivatives from Diastereo-selective Catalytic [3 + 3]-Cycloaddition Reactions of Enoldiazoacetates with Azomethine Imines”, Org. Lett. 2013, 15, 1564-1567.  (IF = 6.732)

(4) Yu Qian, Changcheng Jing, Shunying Liu, Wenhao Hu, “A Highly Enantioselective Four-Component Reaction for the Efficient Construction of Chiral β-Hydroxy-α-Amino Acid Derivatives”, Chem. Commun. 2013, 49, 2700-2702.  (IF = 6.567).

(5) Yu Qian, Changcheng Jing, Changwei Zhai, Wenhao Hu,A Novel Method for Synthesizing N-Alkoxycarbonyl Aryl α-Imino Esters and Their Applications in Enantioselective Transformations”, Adv. Synth. Catal. 2012, 354, 301-307. (IF = 5.663)

(6) Yu Qian, Charles S. Shanahan, Michael P. Doyle, “Templated Carbene Metathesis Reactions from the Modular Assembly of Enoldiazo Compounds and Propargyl Acetates” Euro. J. Org. Chem. 2013, 27, 6032-6037. (IF = 3.065)

(7) Yu Qian, Changcheng Jing, Taoda Shi, Jingjing Ji, Min Tang, Jin Zhou, Changwei Zhai, Wenhao Hu, Cooperative Catalysis in Highly Enantioselective Multi-component Reaction with Water: An Effieient Approach to Synthesize Chiral β-amino-α-hydroxyl Acid Derivatives”, ChemCatChem. 2011, 3, 653-656. (IF = 4.556)

(8) Yu Qian, Xinfang Xu, Liqing Jiang, D. Prajapati, Wenhao Hu, “A Strategy to Synthesize Taxol Side Chain and (−)-epi Cytoxazone via Chiral Brønsted Acid-Rh2(OAc)4 Co-catalyzed Enantioselective Three-Component Reactions”, J. Org. Chem. 2010, 75, 7483-7486. (IF = 4.785)

(9) QingQing Cheng, Yu Qian, Peter Y. Zavalij, and Michael P. Doyle, “Lewis Acid/Rhodium-Catalyzed Formal [3 + 3]-Cycloaddition of Enoldiazoacetates with Donor–Acceptor Cyclopropanes”, Org. Lett. 2015, 17, 3568-3571. (IF = 6.732)

(10) Xingfang Xu, Yu Qian, Liping Yang, Wenhao Hu, Cooperative catalysis in highly enantioselective Mannich-type three-component reaction of a diazoacetophenone with an alcohol and an imine”, Chem. Commun. 2011, 47, 797-799. (IF = 6.567)

(11) Lin Qiu, Xin Guo, Yu Qian, Changcheng Jing, Chaoqun Ma, Shunying Liu, Wenhao Hu,  “Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives”, Chem. Commun. 2016, 52, 11831-11833. (IF = 6.567)

 (12) Changwei Zhai, Dong Xing, Yu Qian, Jingjing Ji, Chaoqun Ma and Wenhao Hu, “Trapping of Carboxylic Oxonium Ylides with N-Boc Imines for the Facile Synthesis of β-Amino Alcohol Derivatives”, Synlett. 2014, 25, 1745-1750. (IF = 2.419)

(13) Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, Wenhao Hu, “Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates”, Angew. Chem. Int. Ed. 2013, 52, 9289-9292. (IF = 13.455)

(14) Wei Shi, Yuejiao Duan, Yu Qian, Ming Li, Liping Yang, Wenhao Hu, “Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors”, Bioorg. Med. Chem. Lett. 2010, 20, 3592-3595. (IF = 2.331)

 (15) Jun Jiang, Xiaochu Ma, Shunying Liu, Yu Qian, Fengping Lv, Lin Qiu, Xiang Wu, Wenhao Hu, “Enantioselective trapping of phosphoramidate ammonium ylides with imino esters for synthesis of 2,3-diaminosuccinic acid derivatives”, Chem. Commun. 2013, 49, 4238-4240. (IF = 6.567)

(16) Jingjing Ji, Xia Zhang, Yingguang Zhu, Yu Qian, Jing Zhou, Liping Yang, Wenhao Hu, “Diastereoselectivity Switch in Cooperatively Catalyzed Three-Component Reactions of an Aryldiazoacetate, an Alcohol, and a β,γ-Unsaturated α-Keto Ester”,  J. Org. Chem. 2011, 76, 5821-5824. (IF = 4.785)

 

 

PATENTS

 

1. 胡文浩,石炜,段月姣,钱宇,厉铭,杨琍苹;含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法;专利号:ZL200910053046.9

2. 胡文浩,荆常诚,钱宇,周静,张霞,孙照栓,杨琍苹;一种α,β-二氨基酸衍生物及其合成方法和应用;专利号:ZL201110357971.8.

3. 胡文浩,翟昌伟,钱宇,季竞竞,马超群,张霞,周静,杨琍苹;一种α-羟基-β-氨基酮衍生物及其合成方法和应用;专利号:ZL201110357986.4

4. 胡文浩,江俊,马晓初,钱宇,吕峰平,邱林,周静,杨琍苹; 一种α一位季碳的α, β一二胺酸衍生物及其合咸方法和应用;申请专利号:201110357963.3

5. 胡文浩,邱林,郭鑫,钱宇,荆常诚,马超群,谢叶归,刘顺英,杨琍苹; 一种具有光学活性胺基羟基氨基酸衍生物的制备方法;专利申请号:201310087156.3

6. 胡文浩,邱林,郭鑫,钱宇,荆常诚,马超群,谢叶归,刘顺英,杨琍苹;具有光学活性α-胺基β-羟基氨基酸衍生物及其制备方法和应用;专利申请号: 201310573482.5

7. 胡文浩, 钱宇, 徐新芳, 杨琍苹,一种不对称合成手性紫杉醇侧链的方法;申请专利号:200910053048.8