药物化学

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邱 晃 [副教授]

邱 晃

联系方式

办公电话:13326430126

电子邮箱:qh682@126.com

办公地址:广东省广州市广州大学城外环东路132号中山大学药学院 邮编:510006

简单介绍

邱晃 博士、副教授、硕士导师。2017年3月通过中山大学“百人计划”引进入职药学院。主要研究方向为重氮化学方法学研究及在药物分子合成中的应用、不对称催化等。曾在国际权威期刊Nat. Chem., J. Am. Chem. Soc.等发表论文。

教育经历

2006.09-2010.07 中国海洋大学 材料化学 学士

2010.09-2013.08 华东师范大学 有机化学 获得直博资格,期间被公派到美国马里兰大学攻读联合博士学位

2013.08-2016.07 美国马里兰大学 有机化学 博士 

工作经历

2016.08美国Scripps研究所 博士后 

科研项目

中山大学“百人计划二期”启动项目

论著专利

1.H. Qiu† , M. Li†, L. Jiang, F. Lv, L. Zan, C. Zhai, M. P. Doyle, W. Hu*, “Highly Enantio-selective Trapping of Zwitterionic Intermediates by Imines” Nat. Chem.2012,4,733-738. (†co-first author)

2.H. Qiu, H. D. Srinivas, P.Y. Zavalij, M. P. Doyle*, “Unprecedented Intramolecular [4 + 2]-Cycloaddition between a 1,3-Diene and a Diazo Ester” J. Am. Chem. Soc., 2016, 138, 1808−1811.

3.H. Qiu, Y. Deng, K. O. Marichev, M. P. Doyle*, “Diverse Pathways in Catalytic Reactions of Propargyl Aryldiazoacetates: Selectivity between Three Reaction Sites” J. Org. Chem., 2017, 82,1584–1590

4.H. Qiu, D. Zhang, S. Liu, L. Qiu, J. Zhou, Y. Qian, C. Zhai, W. Hu*, “Asymmetric C-H Functionalization of Indoles via Enantioselective Protonation,” Acta Chim. Sinica, 2012, 70, 2484-2488. (Cover paper)

5.K. O. Marichev, H. Qiu, A. C. Offield, H. Arman, M. P. Doyle*, “Catalyst-Free Rearrangement of Allenyl Aryldiazoacetates into 1,5-Dihydro-4H-pyrazol-4-ones” J. Org. Chem., 2016, 81, 9235–9246.

6.A. Duan, P. Yu, F. Liu, H. Qiu, M. P. Doyle and K. N. Houk, “Diazo Esters as Dienophiles in Intramolecular (4+2) Cycloadditions: Computational Explorations of Mechanism” J. Am. Chem. Soc.,2017, 139, 2766−2770.

7.Y. Deng, H. Qiu, H. D. Srinivas, M. P. Doyle, “Chiral Dirhodium(II) Catalysts for Selective Metal Carbene Reactions”, Curr. Org. Chem., 2015, 20, 61-81.

8.L. Qiu, X. Guo, C. Ma, H. Qiu, S. Liu, L. Yang, W. Hu*, “Efficient Synthesis of Chiral Cyclic Acetals by Metal and Brønsted Acid Co-catalyzed Enantioselective Four-Component Cascade Reactions” Chem. Commun., 2014, 50, 2196-2198.

9.D. Zhang, H. Qiu, L. Jiang*, F. Lv, C. Ma, W. Hu*, “Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines” Angew. Chem. Int. Ed. 2013, 52, 13356–13360.

10.D. Xing*, C. Jing, X. Li, H. Qiu, W. Hu*, “Highly Efficient Synthesis of Mixed 3,3’-Bisindoles via Rh(II)-Catalyzed Three-Component Reaction of 3-Diazooxindoles with Indoles and Ethyl Glyoxylate” Org. Lett.,2013,15, 3578–3581.

11.X. Han, M. Gan, H. Qiu, J. Ji, X. Zhang, L. Jiang,* W. Hu*, “Trapping of Oxonium Ylides with Michael Acceptors: Highly Diastereoselective Three-Component Reactions of Diazo Compounds with Alcohols and Benzylidene Meldrum’s Acids/4-Oxo-enoates” Synlett 2011, 12, 1717–1722.

12.L. Chen, J. Tian*, H. Qiu, Y. Yin, X. Wang, J. Dai, P. Wu, A. Wang, L. Chu “Preparation of TiO2 nanofilm via sol–gel process and its photocatalytic activity for degradation of methyl orange” Ceramics International 2009; 35, 3275-3280.


专利

1. 胡文浩, 邱晃, 翟昌伟, 张霞, 周静, 杨苹; 一种光学活性色胺衍生物及其合成方法和应用; 专利申请号:201110357937.0

2. 胡文浩, 邢栋, 李新峰, 荆常诚, 邱晃;3,3-二取代氧化吲哚衍生物及其合成方法和应用;专利申请号:201310280369.8

3. 胡文浩,张丹,姜丽琴,邱晃,吕峰平,马超群;一类光学活性吡咯衍生物及其合成方法;专利申请号:201310280369