药理学

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李卓明 [副教授,硕士生导师]

李卓明

联系方式

办公电话:

电子邮箱:lizhm5@mail.sysu.edu.cn

办公地址:药学院226

简单介绍

李卓明,博士,中山大学药学院药理毒理实验室副教授、硕士生导师2012年获香港大学心血管药理专业博士学位,同年加入中山大学药学院担任讲师,2017年1月起担任副教授。主要从事心血管药理学研究,针对蛋白翻译后修饰(乙酰化、磷酸化、多聚核糖基化)对心血管系统功能的调控,开展心肌肥大、内皮功能障碍、动脉粥样硬化的发病机制和防治靶标研究。主持国家自然科学基金青年基金、教育部博士点基金新教师项目、广东省自然科学基金等各级科研项目6项。共发表SCI论文20余篇,其中以第一作者及通讯作者在HypertensionAmerican journal of physiology-Heart and circulatory physiologyTranslational Research等国际知名SCI期刊发表文章10余篇,其中JCR一区6篇,JCR二区3篇,单篇最高影响因子6.2,平均影响因子3.56。担任Plos OneCanadian Journal of Physiology & PharmacologyActa Pharmacologica Sinica国际期刊的常邀审稿人。

教学情况

讲授《药理学》、《药理学实验》、《人体解剖生理学》、《生理学实验》、《病理生理学》、《Pharmacology II》等药学本科课程,以及《心血管药理学》、《药理学研究进展》等研究生课程。

论著专利

1. Jing Lu, Renwei Zhang, Huiqi Hong, Zuolong Yang, Duanping Sun, Xiuli Fang, Shuya Sun, Jiantao Ye, Zhuoming Li *, Peiqing Liu *. The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy. Biochim Biophys Acta-Molecular Cell Research. 2016 Sep 27. pii: S0167-4889(16)30248-8. doi: 10.1016/j.bbamcr.2016.09.019.       (IF: 5.128)

2. You Jia, Yue Zhongbao, Chen Shaorui, Chen Yanfang, Lu Xia, Zhang Xiaoying, Shen Peiye, Li Jingyan, Han Qingfang, Li Zhuoming , Liu Peiqing . Receptor-Interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes. Acta Physiol (Oxf). 2016 Sep 10. doi: 10.1111/apha.12800.      (IF: 4.066)

3. Zhang Xiaoying, Li Wei, Shen Peiye, Feng Xiaojun, Yue Zhongbao, Lu Jing, You Jia, Li Jingyan, Gao Hui, Fang Shi, Li Zhuoming , Liu Peiqing *­­. STAT3 suppression is involved in the protective effect of SIRT6 against cardiomyocyte hypertrophy. Journal of Cardiovascular Pharmacology. 2016 Sep;68(3):204-14.     (IF: 2.462)

6. Li Jingyan, Gao Hui, Huang Junying, Wang Panxia, Huang Yi, Luo Wenwei, Zhang Xiaoying, Shen Peiye, You Jia, Cai Sidong, Li Zhuoming *, Liu Peiqing *. PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy. Journal of Pharmacological Sciences. 2016. pii: S1347-8613(16)30004-4. doi: 10.1016/j.jphs.2016.03.010.     (IF: 2.106)

7. Liu Zhiping, Wang Jiaojiao, Huang Xiaoyang, Li Zhuoming *, Liu Peiqing *. Deletion of SIRT6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice. Translational Research. 2016 Jun;172:18-29.e2. (IF: 4.557)

8. Liu Xue-ping #, Gao Hui #, Huang Xiao-yang, Chen Yan-fang, Feng Xiao-jun, He Yan-hong, Li Zhuo-ming *, Liu Pei-qing *. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway. Translational Research. 2015, 166(5):459-473.e3.        (IF: 4.557)

9. Gao Hui #, Feng Xiao-Jun #Li Zhuo-Ming #, Li Min, Gao Si, He Yan-Hong, Wang Jiao-Jiao, Zeng Si-Yu, Liu Xue-Ping, Huang Xiao-Yang, Chen  Shao-Rui *, Liu Pei-Qing *. Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides. Arch Biochem Biophys. 2015, 565:76-88.       (IF: 2.807) 

10. Min Liu, Jiantao Ye, Si Gao, Wei Fang, Hong Li, Biao Geng, Jian Zou, Xi Chen, Shaorui Chen, Luankun Zhang, Zhongbao Yue, Yunzi Ma, Hui Gao, Zhuoming Li*, Peiqing Liu*. Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1. Biochem Biophys Res Commun. 2014, 444(3):346-53.      (IF: 2.297)

11. Zhuoming Li, Yu Wang, Ricky Y.K. Man, Paul M. Vanhoutte*. Up-regulation of heme oxygenase-1 potentiates EDH-mediated relaxations in the mesenteric artery of the spontaneously hypertensive rat. American journal of physiology-Heart and circulatory physiology. 2013, 305(10):H1471-83.    (IF: 4.012)

12. Zhuoming Li, Yu Wang, Paul M. Vanhoutte*. Up-regulation of Heme oxygenase-1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension. 2011, 58:926–934.      (IF: 6.207)

13. Zhuoming Li, Yu Wang, Paul M. Vanhoutte*. Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat. Basic Clin Pharmacol Toxicol. 2011, 109(1):47-55. (IF: 2.179)


获奖情况

1. 2015中山大学优秀班主任/学生导师

2. “2015中国药理学会教学与科普专业委员会第二届青年教师教学基本功竞赛三等奖

3. 广东省药理学会第七届2015学术交流大会青年优秀论文评比二等奖

4.“2011中国药理学会第十一次全国学术大会、中国药理学会——香港药理学会英文学术报告优秀青年英文报告”三等奖

5.1st prize award of outstanding oral presentation in Institute of Cardiovascular Science and Medicine 14th Annual Scientific Meeting 2010

6.Outstanding oral presentation award in Hong Kong Pharmacology Society 13th Annual Scientific Meeting2010