药剂学

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赵春顺 [教授,博士生导师]

赵春顺

联系方式

办公电话:020-39943118

电子邮箱:zhaocs@mail.sysu.edu.cn

办公地址:广州市大学城外环东路132号 中山大学药学院,邮编:510006

简单介绍

赵春顺   博士,教授,博士生导师。2003毕业于沈阳药科大学药剂学专业,获理学博士学位;1995年7月至1997年8月于河北制药集团从事新药研发工作;1999年9月至2000年8月于石药集团从事新药研发工作;2009年11月至2010年11月在北卡罗来纳大学教堂山分校(UNC)药学院从事靶向给药系统研究;2003年9月入职中山大学药学院。近几年来负责国家“十一五”科技重大专项“新药研究开发关键技术研究”专项、“大品种技术改造”专项、国家自然科学基金、广东省科技计划重点项目、平台项目、广州市科技计划重大项目等多项课题。同时,负责并完成企业合作项目30余项;申请专利9项,授权7项;国际PCT 2项,目前已获15个国家授权;发表研究论文50余篇。

研究方向

新型递药系统的设计与评价

生物利用度优势药物晶型的研究

教学情况

本科生:药剂学;药物制剂设计策略与实例

研究生:药物吸收与剂型设计

科研项目

  1. 国家自然基金项目,“基于光触发同步释放ROS与药物的眼内长效植入系统的构建及其用于后囊浑浊防治的评价” (81673369,2017-2020)

  2. 国家自然基金项目,“双功能晶状体囊袋植入系统的构建与性能评价” (81173003,2012-2015)

  3. 广东省科技计划重点项目,“抗缺血性脑卒中候选药物--异吲哚酮类化合物的筛选及临床前研究”,(2015,2015B020211005)

  4. “十一五”国家科技重大专项“重大新药创制”项目“新药研究开发关键技术研究”专项,“高生物利用度及稳定性药物晶型的制备与分析技术及产业化应用”,(2009,2009ZX09501-022,分题负责人);

  5. “十一五”国家科技重大专项“重大新药创制”项目“大品种技术改造”专项,“丁苯酞高端制剂及其作用靶点、机理研究”,(2008,2008ZX09201-007,分题负责人);

  6. 企业合作项目30余项。

论著专利

  1. Yuanfeng He1, Yanjuan Huang1, Ziyuan Huang, Yali Jiang, Xiaoqi Sun, Yifeng Shen, Weijing Chu, Chunshun Zhao*. Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer. J Control Release. 2017; 264:76-88.

  2. Xiaoyu Xu, Ziyuan Huang, Zeqian Huang, Xuefei Zhang, Siyu He, Xiaoqi Sun, Yifeng Shen, Mina Yan, Chunshun Zhao*. Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemo-Photothermal Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017;9(24):20361-20375

  3. Yanjuan Huang, Yuanfeng He, Ziyuan Huang, Yali Jiang, Weijing Chu, Xiaoqi Sun, Liangfeng Huang, Chunshun Zhao*. Coordination self-assembly of platinum-bisphosphonate polymer-metal complex nanoparticles for cisplatin delivery and effective cancer therapy. Nanoscale. 2017, 9:10002-10019

  4. Ziyuan Huang, Liangfeng Huang, Yanjuan Huang, Yuanfeng He, Xiaoqi Sun, Xiang Fu, Xiaoyu Xu, Gaofei Wei, Dawei Chen and Chunshun Zhao*. Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy. Nanoscale. 2017, 9, 15883–15894.

  5. Weijing Chu, Yanjuan Huang, Chanzhen Yang, Yunhui Liao, Xuefei Zhang, Mina Yan, Shengmiao Cui*, Chunshun Zhao*. Calcium phosphate nanoparticles functionalized with alendronate- conjugated polyethylene glycol (PEG) for the treatment of bone metastasis. Int J Pharm., 2017; 516(1-2):352–363

  6. Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao*. Systemic toxicity induced by aggregated layered double hydroxide nanoparticles.  Int J Nanomed. 2017; 12: 7183–7195.

  7. Jiani Huang, Wenyan Gong, Zhiquan Chen, Junying Huang, Qiuhong Chen, Heqing Huang*, Chunshun Zhao*. Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption. Eur J Pharm Sci. 2017; 99:128-136.

  8. Ming Lei, Zihang Peng, Qian Dong, Yuanfeng He, Zhaoguo Zhang, Xuefei Zhang, Mina Yan, Chunshun Zhao*. A Novel Capsular Tension Ring as Local Sustained-Release Carrier for Preventing Posterior Capsule Opacification. Biomaterials, 2016; 89:148-156.

  9. Yunhui Liao, Xuefei Zhang, Chenglin Li, Yanjuan Huang, Ming Lei, Mina Yan,Yuefang Zhou, Chunshun Zhao*. Inclusion complexes of HP-β-cyclodextrin with agomelatine:Preparation, characterization, mechanism study and in vivo evaluation. Carbohydrate Polymers, 2016;147: 415–425

  10. Zhaoguo Zhang, Wenyong Huang, Ming Lei, Yuanfeng He, Mina Yan, Xuefei Zhang, Chunshun Zhao*. Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention. Int J Pharm., 2016;498:1-11

  11. Mina Yan, Zhaoguo Zhang, Shengmiao Cui, Xuefei Zhang,Weijing Chu, Ming Lei, Ke Zeng, Yunhui Liao, Yihui Deng*, Chunshun Zhao*. Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles. Asian J of Pharm. Sci., 2016:396-403

  12. Ke Zeng, Jin Li, Zhaoguo Zhang, Mina Yan, Yunhui Liao, Xuefei Zhang, Chunshun Zhao*. Lipid-coated ZnO nanoparticles as lymphatictargeted drug carriers: study on cell-specific toxicity in vitro and lymphatic targeting in vivo. J. Mater. Chem. B, 2015,3(26):5249-5260

  13. Zujian Lan, Xiaoyu Xu, Wenkai Xu, Jin Li, Zengrong Liang, Xuefei Zhang, Ming Lei, Chunshun Zhao*. Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. Drug Des Devel Ther., 2015:9 3377-3391

  14. Huafang Zhang, Yan Xiao, Shengmiao Cui, Yuefang Zhou, Ke Zeng, Mina Yan, Chunshun Zhao*. Novel galactosylated poly(ethylene glycol)-cholesterol for liposomes as a drug carrier for hepatocyte-targeting. J of Nanosci and Nanotech., 2015;15(6):4058-4069

  15. Mina Yan, Zhaoguo Zhang, Shengmiao Cui, Ming Lei, Ke Zeng, Yunhui Liao, Weijing Chu, Yihui Deng*, Chunshun Zhao*. Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane. Int J Nanomed. 2014;9(1):4867-4878

  16. Yuefang Zhou, Weijing Chu, Ming Lei, Jin Li, Wei Du, Chunshun Zhao*. Application of a continuous intrinsic dissolution-permeation system for relative bioavailability estimation of polymorphic drugs. Int J Pharm., 2014;473(1-2):250-258.

  17. Qian Dong, Shaoling Yi, Zihang Peng, Chunshun Zhao*. The preparation and the in vitro pharmacodynamics study of the intracapsular prolong-preparations for the prevention of posterior capsule opacification. Asian J of Pharm. Sci., 2013;8(5):259-267

  18. Wei Du, Yuefang Zhou, Yafei Gong, Chunshun Zhao*. Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs. Asian J of Pharm. Sci., 2013;8(4):181-190

  19. Yan Xiao, Huafang Zhang, Zhaoguo Zhang, Mina Yan, Ming Lei, Ke Zeng, Chunshun Zhao*. Synthesis of novel tetravalent galactosylated DTPA-DSPE and study on the hepatocyte targeting efficiency in vitro and in vivo. Int J Nanomed. 2013; 8:3033-3050.

  20. Wanwen Li, Shaoling Yi, Zhouhua Wang, Si Chen, Shuang Xin, Jingwen Xie, Chunshun Zhao*. Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies. Int J Pharm. 2011; 420(1):161-171.