微生物与生化药学

您所在的位置:首页 >> 师资力量 >> 王红胜

王红胜 [副教授,博士生导师]

王红胜

联系方式

办公电话:

电子邮箱:whongsh@mail.sysu.edu.cn

办公地址:

简单介绍

   王红胜,男,中山大学药学院副教授,博士生导师、广东省杰青。目前主要研究RNA修饰及非经典雌激素信号在肿瘤发生发展机制及其靶向治疗策略。作为项目负责人先后主持国家自然基金(面上2项、青年1项)、广东省自然科学基金杰出青年基金等12项课题。获第八届中国药学会-赛诺菲青年生物药物奖(2016)、广东省自然科学基金杰出青年基金(2014,“广东特支计划”百千万青年工程拔尖人才,广州市珠江科技新星等荣誉。近五年发表SCI论文58篇,其中通讯作者23/第一作者11。在通讯及第一作者发表的32篇论文中,影响因子大于5的共有13属于中科院JCR期刊分区一区论文11。通讯及第一作者论文总计影响因子超过150。总计引用次数超过1200次,h-index23。获得国家发明专利两项,参加国际性学术会议并做口头汇报多次。被国际知名SCI杂志如Mol Oncol等邀请为审稿人,并任广东省药监局评审专家、国家自然基金一审专家、中国药理学会及中国毒理学会会员。

研究方向

RNA修饰及非经典雌激素信号在肿瘤发生发展机制及其靶向治疗策略。

教育经历

2008.07~2011.06:香港浸会大学生物系,博士;

2003.09~2007.06:中山大学药学院,本科


工作经历

2016.05~2017.07:芝加哥大学化学系(何川教授课题组),访问学者;

2015.01~2015.02:日本国立感染症研究所,访问学者

2014.01~至今:中山大学药学院,副教授,博士生导师;

2011.07~2013.12:中山大学药学院,讲师(师资博士后);



教学情况

《医学细胞生物学》课程负责人

社会/学术任职

被国际知名SCI杂志如Mol Oncol等邀请为审稿人,并任广东省药监局评审专家、国家自然基金一审专家、中国药理学会及中国毒理学会会员。

科研项目

1.           国家自然基金面上项目:雌激素相关受体γ(ERRγ)在三阴性乳腺癌化疗耐药中的作用及机制研究,课题编号:No. 81673454,起止时间:20171月-202012月,项目负责人,54万。

2.           广东省自然基金杰出青年基金:以雌激素相关受体αERRα)为靶点抑制三阴性乳腺癌(TNBC)的作用及分子机制,课题编号:2014A030306025, 起止时间:20151月-201712月,项目负责人,100万。

3.           国家自然基金面上项目:雌激素相关受体αERRα)在三阴性乳腺癌(TNBC)发展及演进中的作用及机制研究,课题编号:No. 81472470,起止时间:20151月-201812月,项目负责人,78万。

4.           广州市珠江科技新星:雌激素相关受体αERRα)作为治疗三阴性乳腺癌(TNBC)靶点的潜在价值,课题编号:No. 1517000390,起止时间:20154月-20183月,项目负责人,30万。

5.           国家自然基金青年基金项目:双酚A对雄性生殖能力跨代影响的表观遗传学分子机制研究,课题编号:No. 31101071,起止时间:20121月-201412月,项目负责人,21万。

6.           香港SKLMP Seed Collaborative Research Fund项目Health risk assessments of residents in the Pearl River Delta exposed to brominated flame retardants (BFRs)No. SCRF0003, 起止时间:20126月-20136月,中方负责人,HK$16.5万。

7.           中山大学青年教师培育计划:G蛋白偶联雌激素受体(GPR-30)在双酚ABPA)诱导乳腺癌上皮间质化(EMT)过程中的分子机制,课题编号:No.12ykpy09,起止时间:20131月-201512月,项目负责人,15万。

8.           广东省科技计划重点引导项目:双酚A通过G蛋白耦联雌激素受体影响精子生成的分子机制研究,课题编号:No. 2012B031500005,起止时间:20131月-201512月,项目负责人,5万。

9.           中国博士后科学基金面上资助:双酚A通过GPER影响雄性生殖能力的分子机制,课题编号:No. 2012M511868,起止时间:20131月-201412月,项目负责人,5万。

10.      华南肿瘤学国家重点实验室开放课题:膜雌激素受体GPER在三阴性乳腺癌(TNBC)发展中的作用及分子机制。课题编号:No. HN2014-09,起止时间:20146月-20156月,项目负责人,5万。

11.      广东省新药设计与评价重点实验室开放基金科研项目GPR30受体在三阴性乳腺癌侵袭转移中的作用及其干预策略,起止时间:20141月-201512月,项目负责人,2万。



论著专利

第一及通讯作者论文(IF按投稿时计):

1.       Liu Q, Chen ZJ, Jiang GM, Zhou Y, Yang XL, Huang HB, Liu H, Du J, Wang HS*. Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. Mol Cancer (2017) 16 (1): 87. (IF: 6.202)(通讯作者)

2.       Liang S, Chen Z, Jiang G, Zhou Y, Liu Q, Su Q, Wei W, Du J, Wang H*. Activation of GPER suppresses migration and angiogenesis of triple negative breast cancer via inhibition of NF-κB/IL-6 signals. Cancer Lett. (2017) 386: 12-23. (IF: 6.375)(通讯作者)

3.       Jiang GM, Wang HS*, Du J, Ma WF, Wang H, Qiu Y, Zhang QG, Xu W, Liu HF, Liang JP*. Bortezomib Relieves Immune Tolerance in Nasopharyngeal Carcinoma via STAT1 Suppression and Indoleamine 2,3-Dioxygenase Downregulation. Cancer Immunol Res. (2017) doi: 10.1158/2326-6066 (IF: 8.284)(通讯作者)

4.       Chen ZJ, Wei W, Jiang GM, Liu H, Wei WD, Yang X, Wu YM, Wong CK, Du J, Wang HS*. Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF-kappaB signals. Molecular Oncology (2016) 10(6):775-88. (IF: 5.311)(通讯作者)

5.       Wu YM, Chen ZJ, Jiang GM, Zhang KS, Qiao L, Liang SW, Zhou Y, Huang HB, Du J*, Wang HS*. Inverse agonist of estrogen-related receptor alpha suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways. Oncotarget (2016) 7:12568-12581. (IF: 5.007) (通讯作者)

6.       Wu YM, Chen ZJ, Liu H, Wei WD, Lu LL, Yang XL, Liang WT, Liu T, Liu HL, Du J*, Wang HS*. Inhibition of ERRalpha suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin. Oncotarget (2015) 6:25588-25601. (IF: 6.358) (通讯作者)

7.       Chen ZJ*, Yang XL, Liu H, Wei W, Zhang KS, Huang HB, Giesy JP, Liu HL, Du J, Wang HS*. Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions. Archives of Toxicology (2015) 89:1371-1381. (IF: 5.980)(通讯作者)

8.       Jiang GM#, Xie WY#, Wang HS#, Du J, Wu BP, Xu W, Liu HF, Xiao P, Liu ZG, Li HY, Liu SQ, Yin WJ, Zhang QG, Liang JP, Huang HJ. Curcumin combined with FAPalphac vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-alpha in melanoma. Oncotarget (2015) 6:25932-25942. (IF: 6.627) (共同第一作者)

9.       Wei W, Chen ZJ, Zhang KS, Yang XL, Wu YM, Chen XH, Huang HB, Liu HL, Cai SH, Du J*, Wang HS*. The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo. Cell Death and Disease (2014) 5:e1428. (IF: 6.044)(通讯作者)

10.    Chen ZJ, Liu HY, Cheng Z, Man YB, Zhang KS, Wei W, Du J, Wong MH*, Wang HS*. Polybrominated diphenyl ethers (PBDEs) in human samples of mother-newborn pairs in South China and their placental transfer characteristics. Environ Int (2014) 73:77-84. (IF: 6.248)(通讯作者)

11.    Wang HS*, Chen ZJ, Wei W, Man YB, Giesy JP, Du J, Zhang G, Wong CK, Wong MH. Concentrations of organochlorine pesticides (OCPs) in human blood plasma from Hong Kong: markers of exposure and sources from fish. Environ Int (2013) 54:18-25. (IF: 6.248) (通讯作者)

12.    Wang HS, Chen ZJ, Ho KL, Ge LC, Du J, Lam MH, Giesy JP, Wong MH, Wong CK. Hydroxylated and methoxylated polybrominated diphenyl ethers in blood plasma of humans in Hong Kong. Environ Int (2012) 47:66-72. (IF: 6.248) (通讯作者)

13.    Jiang GM#, Wang HS#, Zhang F, Zhang KS, Liu ZC, Fang R, Wang H, Cai SH, Du J. Histone deacetylase inhibitor induction of epithelial-mesenchymal transitions via up-regulation of Snail facilitates cancer progression. BBA-Mol Cell Res (2013) 1833:663-671 (IF: 5.538) (共同第一作者)

14.    Chen ZJ, Zhang KS, Ge LC, Liu H, Chen LK, Du J, Wang HS*. Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis. Toxicol Res, 2016, 5, 1573-1584 (IF: 3.983) (通讯作者)

15.    Qi YF, Wu L, Li ZQ, Wu ML, Wang HF, Chan KY, Lu LL, Cai SH, Wang HS*, Du J*. Nodal signaling modulates the expression of Oct-4 via nuclear translocation of β-catenin in lung and prostate cancer cells. Arch Biochem Biophys. (2016) 15;608:34-41. (IF: 2.807) (通讯作者)

16.    Lu LL, Chen XH, Zhang G, Liu ZC, Wu N, Wang H, Qi YF, Wang HS*, Cai SH*, Du J*. CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3/Snail Signals. Oxid Med Cell Longev (2016) 2016:5874127. (IF: 3.516) (通讯作者)

17.    Chen ZJ, Liu HY, Ho KL, Huang HB, Liu Q, Man YB, Lam MH, Du J, Wong MH, Wang HS*. Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in paired maternal and neonatal samples from South China: Placental transfer and potential risks. Environ Res (2016) 148:72-78. (IF: 4.373) (通讯作者)

18.    Wang ZT, Chen ZJ*, Jiang GM, Wu YM, Liu T, Yi YM, Zeng J, Du J, Wang HS*. Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells. Cell Signal (2016) 28:506-515. (IF: 4.315) (通讯作者)

19.    Chen XH, Liu ZC, Zhang G, Wei W, Wang XX, Wang H, Ke HP, Zhang F, Wang HS*, Cai SH*, Du J*. TGF-beta and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. Molecular Immunology (2015) 65:34-42. (IF: 3.003) (通讯作者)

20.    Ge LC, Wang HS*. A commentary on "Involvement of activating ERK1/2 trough G protein coupled receptor 30 and estrogen receptor alpha/beta in low doses of bisphenol A promoting growth of Sertoli TM4 cells". Toxicol Lett (2016) 240:236-237. (IF: 3.145)(通讯作者)

21.    Ge LC, Chen ZJ, Liu H, Zhang KS, Su Q, Ma XY, Huang HB, Zhao ZD, Wang YY, Giesy JP, Du J*, Wang HS*. Signaling related with biphasic effects of bisphenol A (BPA) on Sertoli cell proliferation: a comparative proteomic analysis. Biochim Biophys Acta (2014) 1840:2663-2673. (IF: 3.848) (通讯作者)

22.    Ge LC, Chen ZJ, Liu HY, Zhang KS, Liu H, Huang HB, Zhang G, Wong CK, Giesy JP, Du J*, Wang HS*. Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor alpha/beta in low doses of bisphenol A promoting growth of Sertoli TM4 cells. Toxicol Lett (2014) 226:81-89. (IF: 3.145)(通讯作者)

23.    Liu ZC#, Wang HS#, Zhang G, Liu H, Chen XH, Zhang F, Chen DY, Cai SH, Du J*. AKT/GSK-3beta regulates stability and transcription of snail which is crucial for bFGF-induced epithelial-mesenchymal transition of prostate cancer cells. Biochim Biophys Acta (2014) 1840:3096-3105. (IF: 3.848) (共同第一作者)

24.    Wang HS*, Chen ZJ, Cheng Z, Du J, Man YB, Leung HM, Giesy JP, Wong CK, Wong MH*. Aquaculture-derived enrichment of hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs) in coastal sediments of Hong Kong and adjacent mainland China. Sci Total Environ (2014) 466-467:214-220. (IF: 3.258)(通讯作者)

25.    Wang HS*, Jiang GM, Chen ZJ, Du J, Man YB, Giesy JP, Wong CK, Wong MH*. Concentrations and congener profiles of polybrominated diphenyl ethers (PBDEs) in blood plasma from Hong Kong: Implications for sources and exposure route. J Hazard Mater (2013) 261:253-259. (IF: 4.173)(通讯作者)

26.    Wang HS*, Xu WF, Chen ZJ, Cheng Z, Ge LC, Man YB, Giesy JP, Du J, Wong CK, Wong MH*. In vitro estimation of exposure of Hong Kong residents to mercury and methylmercury via consumption of market fishes. J Hazard Mater (2013) 248-249:387-393. (IF: 4.173)(通讯作者)

27.    He YW#, Wang HS#, Zeng J, Fang X, Chen HY, Du J, Yang XY. Sodium butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal carcinoma cells. Life Sciences (2013) 93:509-515. (IF: 2.555) (共同第一作者)

28.    Wang HS*, Sthiannopkao S, Chen ZJ, Man YB, Du J, Xing GH, Kim KW, Mohamed Yasin MS, Hashim JH, Wong MH*. Arsenic concentration in rice, fish, meat and vegetables in Cambodia: a preliminary risk assessment. Environ Geochem Health (2013) 35:745-755. (IF: 2.076) (通讯作者)

29.    Cheng Z, Wang HS*, Du J, Sthiannopkao S, Xing GH, Kim KW, Yasin MS, Hashim JH, Wong MH. Dietary exposure and risk assessment of mercury via total diet study in Cambodia. Chemosphere (2013) 92:143-149. (IF: 3.206)  (通讯作者)

30.    Wang HS*, Chen ZJ, Zhang G, Ou XL, Yang XL, Wong CK, Giesy JP, Du J*, Chen SY. A novel micro-linear vector for in vitro and in vivo gene delivery and its application for EBV positive tumors. Plos One (2012) 7:e47159. (IF: 4.092)(通讯作者)

31.    Wang HS, Du J, Ho KL, Leung HM, Lam MH, Giesy JP, Wong CK, Wong MH*. Exposure of Hong Kong residents to PBDEs and their structural analogues through market fish consumption. J Hazard Mater (2011) 192:374-380. (IF: 4.173)(第一作者)

32.    Wang HS, Sthiannopkao S, Du J, Chen ZJ, Kim KW, Mohamed Yasin MS, Hashim JH, Wong CK, Wong MH*. Daily intake and human risk assessment of organochlorine pesticides (OCPs) based on Cambodian market basket data. J Hazard Mater (2011) 192:1441-1449. (IF: 4.173)(第一作者)

33.    Wang HS, Zhao YG, Man YB, Wong CKC, Wong MH*. Oral bioaccessibility and human risk assessment of organochlorine pesticides (OCPs) via fish consumption, using an in vitro gastrointestinal model. Food Chem. (2011) 127:1673-1679. (IF: 3.146) (第一作者)

34.    Wang HS, Du J, Leung HM, Leung AO, Liang P, Giesy JP, Wong CK, Wong MH*. Distribution and source apportionments of polychlorinated biphenyls (PCBs) in mariculture sediments from the Pearl River Delta, South China. Mar Pollut Bull (2011) 63:516-522. (IF: 2.630) (第一作者)

35.    Wang HS, Man YB, Wu FY, Zhao YG, Wong CK, Wong MH*. Oral bioaccessibility of polycyclic aromatic hydrocarbons (PAHs) through fish consumption, based on an in vitro digestion model. J Agric Food Chem (2010) 58:11517-11524 (IF:2.562) (第一作者)

36.    Wang HS, Liang P, Kang Y, Shao DD, Zheng GJ, Wu SC, Wong CK, Wong MH*. Enrichment of polycyclic aromatic hydrocarbons (PAHs) in mariculture sediments of Hong Kong. Environ Pollut (2010) 158:3298-3308. (IF: 3.426) (第一作者)

37.    Wang HS, Cheng Z, Liang P, Shao DD, Kang Y, Wu SC, Wong CK, Wong MH*. Characterization of PAHs in surface sediments of aquaculture farms around the Pearl River Delta. Ecotoxicol Environ Saf (2010) 73:900-906. (IF: 2.590) (第一作者)

专利:

1.              王红胜;韦微;杜军;陈卓佳,国家发明专利:《G-1在制备基于G蛋白偶联受体30的三阴性乳腺癌靶向药物方面的应用》专利号:201410209369.3,申请日: 20140519日;公开号:201410209369,授权日:201655

2.              杜军; 何玉文; 王红胜,国家发明专利:《一种基因微链载体及其构建方法和应用》申请号:200710030825.8;公开号:CN 101173294  专利号:ZL2007 1 0030825.8 申请日: 20071012日,公开日:200857日,授权日:20110126


获奖情况

1.      第八届中国药学会-赛诺菲青年生物药物奖(2016

2.           广东省自然基金杰出青年基金获得者(2014);

3.           “广东特支计划”百千万青年工程拔尖人才(2015);

4.           广州市珠江科技新星(2014);

5.           广东省千百十工程第七批校级培养对象(2012


学术交流

2016.05~2017.07:芝加哥大学化学系(何川教授课题组),访问学者;

2015.01~2015.02:日本国立感染症研究所,访问学者