药剂学

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潘 昕 [副教授]

潘  昕

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简单介绍

潘昕,女,中山大学药学院副教授。2011年毕业于中山大学,获药剂学博士学位,后留校任教。

研究方向

主要研究领域为药物新型制剂和药物释放系统,近年来承担课题10余项,其中包括国家自然科学基金青年基金、863子课题、2014年度珠江科技新星、教育部博士点基金、中国博士后科学基金第51批面上资助、广东省医学科研基金等项目。在国内外重要学术刊物,包括Eur J Pharm Sci, Eur J Pharm Biopharm, Int J Nanomed, Curr Pharm Design, Int J Pharm, AAPS Pharmscitech等发表论文30余篇,并获得7项有关制剂应用基础研究的授权专利及专利申请。 

教育经历

2006.09-2011.06     博士,药剂学, 中山大学,广州 

2002.09-2006.07     学士,药学,中山大学,广州

工作经历

2015.12至今             中山大学药学院副教授

2013.07-2015.12        中山大学药学院讲师

2011.07-2013.06        中山大学药学院师资博士后

社会/学术任职

1)        广东省药学会药物制剂专业委员会秘书长

2)        第二届工业药学与临床药学研讨会(Symposium on Industrial Pharmacy and Clinical Pharmacy)组委会组长

3)        国际专业杂志Drug Development and Industrial Pharmacy、Analyze method等特邀评审

4)        美国药学科学家协会American Association of Pharmaceutical Scientists (AAPS) 会员

5)        国际控释协会Control Release Society (CRS) 会员

6)        中国吸入制剂联盟Inhalation Drug Delivery Association (IDDA) 会员

7)        美国药学科学家协会中山大学学生分会(AAPS Sun Yat-Sen University Student Branch ) 发起人

科研项目

1)         “基于超细微粒制备技术的微粒成丸机理研究及其在微丸片中的应用”;国家自然科学基金青年基金;23万元;项目负责人;2011-2015年。

2)        “基于超细微粒制备技术的微粒成球机理研究及其在石杉碱甲口崩型缓释微丸片中的应用”;教育部博士点基金新教师类;4万元;项目负责人;2012-2014年。

3)        “基于超细微粒制备技术的微粒成丸机理及其在口崩型缓释微丸片的中的应用”;中国博士后科学基金委; 5万元;项目负责人;2011-2013年。

4)        “石杉碱甲口崩型缓释微丸片的研究”;广东省卫生厅医学科研基金;0.5万元;项目负责人;2012-2013年。

5)        “青年教师起步计划”;中山大学;2万元;项目负责人; 2011-2012年。

6)        “缓释制剂处方工艺及质量研发”; 广州新济药业科技有限公司;10 万元;项目负责人;2009-2013年。

7)         “E/D口服溶液研究开发”; 广州新济药业科技有限公司;10 万元;项目负责人;2012-2016年。

8)         “临床营养关键技术及其产品研发”;中国科学技术部;415万元;项目参与人;2012-2016年。

9)         “促进药物透皮的皮肤靶向立方液晶纳米凝胶载药体系研究”;国家自然科学基金委;21万;项目参与人;2012-2016年。

10)    “新型立方液晶栓塞剂构建及其抗癌作用机制研究”;国家自然科学基金委;58万;项目参与人;2012-2015年。

11)    “广东省高校创新药物制剂工程技术研究中心”;广东省教育厅;80 万元;项目参与人;2009-2010年;已结题。

论著专利

1)        Z. Zhang, G. Quan, Q. Wu, Chan Zhou, F. Li, X. Bai, G. Li, X. Pan, C. Wu*, Loading amorphous Asarone in mesoporous silica SBA-15 through supercritical carbon dioxide technology to enhance dissolution and bioavailability, Eur. J. Pharm. Biopharm. 92 (2015) 28-31.

2)        Y. Dong, P. Dong, D. Huang, L. Mei, Y. Xia, Z. Wang, X. Pan, G. Li, C. Wu*, Fabrication and characterization of silk fibroin-coated liposomes for ocular drug delivery, Eur. J. Pharm. Biopharm. 91 (2015) 82-90.

3)        G. Quan, X. Pan, Z. Wang, Q. Wu, G. Li, L. Dian, B. Chen, C. Wu*, Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery, J. Nanobiotecg. 13 (2015) 7-18.

4)        T. Peng. C. Zhu. Y. Huang, G. Quan, L. Huang, L. Wu, X. Pan*, G. Li, C. Wu, Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients, Powder Technol. 270 (2015), 221-229.

5)        Y. Huang, C Zhu, G Li, X. Pan*, C.Wu. Metoprolol Tartrate Sustained-release Binary Matrix Microspheres for Oral Administration Produced by Novel Ultra-fine Particle Processing System, Powder Technology. Accept for publication on 2015, 285: 44-50.

6)        C Zhu, Y. Huang, Xiaoying Zhang , Liling Mei, G Li, X. Pan*, C.Wu, Comparative studies on exenatide-loaded poly (D, L-lactic-co-glycolic acid) microparticles prepared by a novel ultra-fine particle processing system and spray drying. Colloids and Surfaces B: Biointerfaces, Accept for publication online 2015, 132:103-110.

7)        J. Ji, J. Zhang, J. Chen, Y. Wang, X. Wang, N. Dong, C. Hu, H. Chen, G. Li, X. Pan*, C. Wu, Preparation and Stabilization Mechanism of Emulsions Stabilized by Mixed Sodium Caseinate and Soy Protein Isolate, Food Hydrocolloids. 2015, 51: 156-165.

8)        X. Shi, T. Peng, Y. Huang, L. Mei, Y. Gu, J. Huang, K. Han, G. Li, C. Hu, X. Pan*, C. Wu*. Comparative studies on glycerol monooleate-and phytantriol-based cubosomes containing oridonin in vitro and in vivo. Pharmaceutical Development and Technology, 2015, 12:1-10.

9)        T. Peng, Y. Huang, L. Mei, L. Wu, L. Chen, X. Pan*, C. Wu*. Study progression in application of process analytical technologies on film coating. Asian Journal of Pharmaceutical Sciences. 2015, 10(3), 176-185.

10)    X. Peng, Y. Zhou, K. Han, L. Qin, L. Dian, G. Li, X. Pan*, C. Wu*. Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin. Drug Design, Development and Therapy, 2015, 9: 4209-4218.

11)    T. Peng, Y. Huang, L. Mei, L. Wu, L. Chen, X. Pan*, C. Wu, Study progression in application of process analytical technologies on film coating. Asia Journal of Pharmaceutical Sciences.2015, 10(3): 176-185.

12)    D. Huang, L. Wang, Y. Dong, X. Pan*, G. Li, C. Wu*, A novel technology using transscleral ultrasound to deliver protein loaded nanoparticles, Eur. J. Pharm. Biopharm. 88 (2014) 104-115.

13)    Z. Shan, Y. Tan, L. Qin, G. Li, X. Pan, Z. Wang, X. Yu, Q. Wang, C. Wu*, Formulation and evaluation of novel reverse microemulsions containing salmon calcitonin in hydrofluoroalkane propellants, Int. J. Pharm. 466 (2014) 390-399.

14)    M. Lu, Z. Guo, Y. Li, H. Pang, L. Lin. X. Liu, X. Pan*, C. Wu*, Application of hot melt extrusion for poorly water-soluble drugs: Limitations, Advances and Future prospects, Curr. Pharm. Design 20 (2014) 369-387.

15)    Y. Huang, Q. Yao, C. Zhu, X. Zhang, L. Qin, Q. Wang, X. Pan*, C. Wu, Comparison of novel granulated pellet-containing tablets and traditional pellet-containing tablets by artificial neural networks, Pharm. Dev. Technol. 2014 Apr 24. doi:10.3109/10837450.2014.910809

16)    L. Dian, Z. Yang, F. Li, Z. Wang, X. Pan*, X. Peng, X. Huang, Z. Guo, G. Quan, X. Shi, B. Chen, G. Li, C. Wu*, Cubic phase nanoparticles for sustained release of ibuprofen: formulation, characterization, and enhanced bioavailability study, Int. J. Nanomed. 8 (2013) 845–854.

17)    X. Pan, K. Han, X. Peng, L. Qin, C. Zhu, X. Huang, X. Shi, L. Dian, M. Lu, C. Wu*, Nanostructured cubosomes as advanced drug delivery system, Curr. Pharm. Design 19 (2013) 6290-6297.

18)    X. Pan, Y. Huang, Y. Dong, Z. Wang, C. Zhu, G. Li, B. Chen, C. Wu*, Process investigation of a novel compaction technique with pellet-containing granules, Ther. Innov. Regul. Sci. 47 (2013) 593-601.

19)    Z. Wang, Z. He, L. Zhang, H. Zhang, M. Zhang, X. Wen, G. Quan, X. Huang, X. Pan, C. Wu*, Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling, Acta Pharmaceutica Sinica B 3 (2013) 130-139.

20)    B. Chen, Z. Wang, G. Quan, X. Peng, X. Pan, R. Wang, Y. Xu, G. Li, C. Wu*, In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation, Int. J. Nanomed. 7 (2012) 199-209.

21)    Y. Tan, Z. Yang, X. Pan, M. Chen, M. Feng, L. Wang, H. Liu, Z. Shan, C. Wu*, Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process, Int. J. Pharm. 427 (2012) 385-392.

22)    M. Chen, Z. Yang, H. Wu, X. Pan, X. Xie, C. Wu*, Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel, Int. J. Nanomed. 6 (2011) 2873-2877.

23)    X. Wen, X. Peng, H. Fu, Y. Dong, K. Han, J. Su, Z. Wang, R. Wang, X. Pan, L. Huang, C. Wu*, Preparation and in vitro evaluation of silk fibroin microspheres produced by a novel ultra-fine particle processing system, Int. J. Pharm. 416 (2011) 195-201.

24)    M. Chen, X. Pan, H. Wu, K. Han, X. Xie, D.E. Wedge, M.A. Repka, C. Wu*, Preparation and anti-bacterial properties of a temperature-sensitive gel containing silver nanoparticles, Pharmazie 66 (2011) 272-277.

25)    Z. He, Z. Wang, H. Zhang, X. Pan, W. Su, D. Liang, C. Wu*, Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery, Acta Pharmaceutica Sinica B 1 (2011) 254-260.

 (Pubulication in Chinese)

26)    X. Pan, M. Chen, K. Han, X. Peng, X. Wen, B. Chen, J. Wang, G. Li, C. Wu*, Novel compaction techniques with pellet-containing granules, Eur. J. Pharm. Sci. 75 (2010) 436-442.

27)    K. Han, X. Pan, M. Chen, R. Wang, Y. Xu, M. Feng, G. Li, M. Huang, C. Wu*, Phytantriol-based inverted type bicontinuous cubic phase for vascular embolization and drug sustained release, Eur. J. Pharm. Sci. 41 (2010) 692-699.

28)    X. Peng, X. Wen, X. Pan, R. Wang, B. Chen, C. Wu*, Design and in vitro evaluation of capsaicin transdermal controlled release cubic phase gels, AAPS PharmSciTech, 11 (2010) 1405-1410.

 

授权专利及专利:

1)        潘昕,吴传斌。一种微丸片的制备方法,中国专利号:ZL 201010019558.6

2)        吴传斌,吴涵,潘昕。水溶性药物无水反胶束纳米粒及其混悬型气雾剂的制备方法,中国专利号:201310154231.3

3)        潘昕,黄莹,彭婷婷,张雪娟。表面纳米级粗糙结构的颗粒及其制备方法和应用,中国专利申请号:201610013832.6

4)        潘昕,黄莹,梅丽玲。一种缓释立方液晶液体硬胶囊的制备和应用,中国专利申请号:201610013835.X:

5)        潘昕,陈龙楷,冯地桑,黄莹,吴涵,吴传斌。磷脂蛋白质微粒复合微球及其制备方法。中国专利申请号:201610031750.4

6)        吴传斌,潘昕,付寒。利培酮微球及其制备方法,中国专利申请号:201210078802.5

7)        吴传斌,潘昕,杜鹏阳,李姝瑾。细辛脑干粉吸入剂及其制备方法,中国专利申请号:201210093309.0

8)        吴传斌,潘昕,周玥鋆,温新国。美托洛尔缓释微球、缓释药用组合物及其制备方法,中国专利申请号:201210087607.9

9)        吴传斌,王雯,潘昕。硫酸奈替米星吸入粉雾剂及其制备方法,中国专利申请号:20120457832.7

10)    吴传斌,袁婷,潘昕。骨化三醇固体脂质分散体及其制备方法,中国专利申请号:20120470199.5

学术交流

A.大会报告:

1)        Peptide drug formulation design based on pMDIs, 2015 SYSU-RMIT Joint Symposium, Nov 17-18,2015, Guangzhou China.

2)        蛋白质多肽气雾给药系统的设计与评价,第二届全国生物颗粒研讨会,大会报告,2015年12月,中国广州。

3)        Spray-dried Mannitol-Chitosan as Blend Carrier for Dry Powder Inhalers, Particulate Processes in the Pharmaceutical Industry IV, Sep 11-14, 2014,Potsdam, Germany.

4)        Ultra-fine Particle Process System and Its Application for the Drug-containing Microspheres, The 7thWorld Congress of Particle Technology, May 11-14, 2014, Beijing, China.

5)        临床营养十三五863重大项目立项前期论证会议,大会报告,2013年3月,中国北京。

6)        微丸片制剂产业化技术,中国颗粒学会第八届学术年会,分会场报告,2012年9月,中国杭州。

 

B. 大会交流:

7)        Ying Huang, Xuan Zhang, Chune Zhu, Guilan Quan, Xin Pan, Chuanbin Wu*. Inhalation Properties of Binary Mannitol-Chitosan Carrier with Different Surface Roughness by Spray-dried. 2015 AAPS Annual Meeting, Oct 25-29, 2015, Orlando, USA.

8)        Ying Huang, Yueyun Zhou, Xin Pan, Chuanbin Wu *. Metoprolol Tartrate Sustained-release Microspheres for Oral Administration, The 7th World Congress of Particle Technology, May 19-22, 2014, Beijing, China.

9)        Di Huang, Lili Wang, Yixuan Dong, Xin Pan, Chuanbin Wu*. A novel technology using transscleral ultrasound for nanoparticles delivery. The 7th World Congress of Particle Technology, May 19-22, 2014, Beijing, China.

10)    Guilan Quan, Bao Chen, Zhouhua Wang, Qiaoli Wu, Xin Pan, Chuanbin Wu*. Asialoglycoprotein receptor-targeted mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. The 7thWorld Congress of Particle Technology, May 19-22, 2014, Beijing, China.

11)    Ying Huang, Yujun Xiao, Chune Zhu, JiaYi He, Xin Pan, Chuanbin Wu*, A Novel Oral Administration for Liquid Crystalline Phase Matrix as Sustained Drug Delivery, 2013  AAPS Annual Meeting, November 10-14, 2013, San Antonio, USA, Poster Presentation.

12)    Qingqing Wang, Pin Dong, Zihua Gong, Gangtao Yao, Bingzhen Cai, Xin Pan, Chuanbin Wu*, Fabrication and Optimization of Dissolving Microneedle Arrays as Transdermal Delivery System, 2013  AAPS Annual Meeting, November 10-14, 2013, San Antonio, USA, Poster Presentation.

13)    Chune Zhu, Yan Liu, Ying Huang, JiaYi He, Xin Pan, Chuanbin Wu*, A Novel Polymeric Coating Composition Suitable for Taste-Masking, 2013  AAPS Annual Meeting, November 10-14, 2013, San Antonio, USA, Poster Presentation.

14)    Ziyun Shan, Yinhe Tan, Zhouhua Wang, Xin Pan, Chuanbin Wu*, Reverse Aqueous Microemulsions Containing Salmon Calcitonin in Hydrofluoroalkane Propellants for Aerosol Formulation, 2013  AAPS Annual Meeting, November 10-14, 2013, San Antonio, USA, Poster Presentation.

15)    Chune Zhu, Yan Liu, Ying Huang, Xin Pan*, Studies on Azithromycin Dry Suspensions Containing Taste-masked Pellets, 40th CRS Annual Meeting,July 21-24, 2013,Hawaii, USA, Poster Presentation.

16)    Ying Huang, Yujun Xiao, Chune Zhu, Yan Liu, Xin Pan*, Liquid Crystalline Cubic Phase Precursor Sustained-release Capsules, The 40th CRS Annual Meeting,July 21-24, 2013,Hawaii, USA, Poster Presentation.

17)    Qingqing Wang, Ying Huang, Xin Pan*, Chuanbin Wu, Dissolving Microneedles Drug Release System: Simplification of Fabrication and Influence of Sharps and Structure Materials, The 40th CRS Annual Meeting,July 21-24, 2013,Hawaii, USA, Poster Presentation.

18)    Founding Conference of Inhalation Drug Delivery Association, November 8-9, 2013, Nanjing, China.

19)    The 1st Biological Particles Preparation and Industrialization Technology Seminar, September 20-22, 2013, Urumchi, China.

20)    Yixuan Dong, Xin Pan, Chuanbin Wu*,  Preparation and Characterization of Silk Fibroin-Liposomes for Ophthalmic Drug Delivery, 2012 AAPS Annual Meeting, October 14-18, 2012, Chicago, USA, Poster Presentation.

21)    Xin Pan, Ying Huang, Chuanbin Wu*, Comparison of Pellet-containing Tablets and Granulated Pellet-containing Tablets with Artificial Neural Networks , 2012  AAPS Annual Meeting, October 14-18, 2012, Chicago, USA, Poster Presentation.

22)    Xin Pan, Chune Zhu, Chuanbin Wu*, Influence of Excipients on the Drug Stability of Granulated  Pellet-containing Tablets, 2012  AAPS Annual Meeting, October 14-18, 2012, Chicago, USA, Poster Presentation.

23)    Zhouhua Wang, Xin Pan, Bao Chen, Chuanbin Wu*, Enhancing the Oral Bioavailability of Poorly Water-Soluble Carbamazepine with Immediate-Release Pellets Based on Mesoporous Silica, 2012  AAPS Annual Meeting, October 14-18, 2012, Chicago, USA, Poster Presentation.

24)    Zhouhua Wang, Xin Pan, Chuanbin Wu*, Optimization of Doxycycline and Hydroxypropy-β-Cyclodextrin Complex Formulation for Ophthalmic Delivery Based on Computational Modeling, 2012 AAPS Annual Meeting, October 14-18, 2012, Chicago, USA, Poster Presentation. Xintian Huang, Xin Pan *, Chuanbin Wu, Effects of Medium Chain Triglyceride on Nanostructure and Mechanics of Liquid Crystalline Gels. The 2nd International Symposium for Industrial Pharmacy and Clinical Pharmacy, December 8-9, 2012. Foshan, China, Poster Presentation.

25)    Chune Zhu, Ying Huang, Xin Pan *, Chuanbin Wu, Bioequivalence study of granulated pellet-containing tablets (GPCT) and coated pellets of doxycycline hydrochloride. The 2nd International Symposium for Industrial Pharmacy and Clinical Pharmacy, December 8-9, 2012. Foshan, China, Poster Presentation.

26)    Lingzhen Qin, Pan Xin*, Chuanbin Wu, Effects of Medium Chain Triglyceride on Nanostructure and Mechanics of Liquid Crystalline Gels. The 2nd International Symposium for Industrial Pharmacy and Clinical Pharmacy, December 8-9, 2012. Foshan, China, Poster Presentation.

27)    Ying Huang, Yujun Xiao, Chune Zhu, Pan Xin*, Chuanbin Wu, Effect of Blended Membrane Materials and Additives on Properties of Coating Films. The 2nd International Symposium for Industrial Pharmacy and Clinical Pharmacy, December 8-9, 2012. Foshan, China, Poster Presentation.

28)    Ziyun Shan, Pan Xin*, Chuanbin Wu, A novel process to produce nanoparticles containing protein or peptide for a pMDI suspension. The 2nd International Symposium for Industrial Pharmacy and Clinical Pharmacy, December 8-9, 2012. Foshan, China, Poster Presentation.

29)    Xin Pan, Yixuan Dong, Qiuyu Fang, Ying Huang, Chuanbin Wu*, The Superiority of Granulating Method Preparing Pellet-containing Tablets, The 11st Conference of Chinese Pharmacy, November 5-6, 2011, Yan Tai, China, Poster Presentation.

30)    Xin Pan, Xinsheng Peng, Xinguo Wen, Yixuan Dong, Zhouhua Wang, Chuanbin Wu*, Investigation of Process Parameters of the Granulated Pellets by a Novel Compaction Technique. 2010 AAPS Annual Meeting, November 14-18, 2010, Louisiana, USA, Poster Presentation. 

31)    Xinsheng Peng, Xin Pan, Xinguo Wen, Yixuan Dong, Zhouhua Wang, Chuanbin Wu*, Preparation and Characterization of Capsaicin Transdermal Controlled Release Cubic Phase Gels. 2010 AAPS Annual Meeting, November 14-18, 2010, Louisiana, USA, Poster Presentation. 

32)    Yujun Xiao, Xin Pan, Xinsheng Peng, Xinguo Wen, Yixuan Dong, Zhouhua Wang, Chuanbin Wu*, Preparation and Evaluation of In-situ Gel Intranasal Delivery System of Tetramethylpyrazine Phosphate. 2010 AAPS Annual Meeting, November 14-18, 2010, Louisiana, USA, Poster Presentation.

33)    Ke Han, Xin Pan, Zixin He, Yixuan Dong, Chuanbin Wu*, Application of Docetaxel-loaded Phytantriol Liquid Crystalline in the Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma. 2010 AAPS Annual Meeting, November 14-18, 2010, Louisiana, USA, Poster Presentation.

34)    Meiwan Chen, Ke Han, Xin Pan, Linna Wu, Bao Chen, Chuanbin Wu*. The preparation and anti-bacterial properties of temperature-sensitive spray gel containing silver nanoparticles. The AAPS Journal, 2009, 11(S2):3576.

35)    Ke Han, Xin Pan, Meiwan Chen, Rongchang Wang, Yuehong Xu, Chuanbin Wu*. Liquid crystalline carrier containing contrast agent and anti-tumor drugs for vascular embolization and drug sustained release. The AAPS Journal, 2009, 11(S2):3544.

36)    Xin Pan, Linna Wu, Bao Chen, Meimei Zhang, Yujun Xiao, Chuanbin Wu*. A new method of packing coated pellets for compaction. Proceedings of the Controlled Release Society, 2009, 36: 272

37)    Xin Pan, Bao Chen, Linna Wu, Yang Liu, Haiyan Hu, Chuanbin Wu*. Fragility of the compressed pellets coated with a combination of acrylic polymers. The AAPS Journal, 2008, 10(52):285.