药剂学

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陆明 [副教授,硕士生导师]

陆明

联系方式

办公电话:020-39943119

电子邮箱:luming3@mail.sysu.edu.cn

办公地址:

简单介绍

陆明,博士,硕士生导师,副教授。2007年毕业于中山大学化学与化学工程学院高分子物理与化学专业,获博士学位。留校。2009年进入药学院药剂学与制药工程研究室从事药剂学研究。2015-2016年于美国普渡大学药学院Dr. Lynne S. Taylor课题组以访问学者的身份进行为期一年的合作研究。研究兴趣为热熔挤出药与3D打印药物制剂、药物无定形态与多晶型。研究成果发表在药剂学与晶体学期刊上,其中关于聚合物结晶的研究论文被Polymer期刊评为2011年度Polymer期刊中国区最佳论文提名奖(The Best Paper Nomination From China published in Polymer during 20112014年受邀撰写热熔挤出制剂相关综述2篇,分别发表在Current Pharmaceutical DesignJournal of Pharmacy and Pharmacology杂志上。2015年受邀为英国Greenwhich大学主编的热熔挤出专著撰写热熔挤出制备共晶相关章节《Chapter 10: Continuous cocrystallization of poorly soluble APIs to enhance dissolution》,由SmithersRapra出版社出版。2018年受邀为3D打印专著撰写《Chapter 9. Novel Excipients and Materials Used in 3D Printing of Pharmaceutical Dosage Forms》章节,由John Wiley出版社出版。

 


研究方向

  1. 药物无定形态与多晶型。

  2. 热熔挤出制剂技术及其基本物理化学问题。

  3. 3D打印药物制剂。

教学情况

物理化学(药学院本科生)
基础化学(医学院本科生)
药用高分子与新型给药系统(药学院本科生)

科研项目

主持项目:

1. 基于小分子氢键组份的热敏性药物熔融温度调控及其在热熔挤出过程中稳定机制研究,广东省科学基金,2018.5-2021.4

2. 基于尺寸效应的剪切诱导聚合物晶型转变研究,国家自然科学基金面上青年基金,项目编号51103184 2012.1.-2014.12.

3. 基于热熔挤出的药物-聚合物相互作用研究,高校基本业务费青年教师培育项目。项目编号12ykpy08 2012.12.1.-2015.12.1.

4. 热熔挤出构建伊曲康唑干粉吸入剂及其体内外评价,广东省医学科研基金,项目编号A20151692015.6-2017.6

5. 基于过冷液体快速筛选药物共晶,中山大学大学生创新训练计划项目,2018.4-2018.12

6. 3D打印构建治疗甲癣的个性化透甲贴片,中山大学大学生创新训练计划项目,2018.4-2019.5

7. 烟酰胺五种新晶型的发现和研究,中山大学大学生创新训练计划项目,2018.4-2018.12

8. 聚合物-药物分子间作用力对抗黑色素瘤药物Vemurafenib结晶速率及多晶型的调控及作用机制研究,中山大学实验室开放基金项目,2016.12-2017.12

9. 伊曲康唑干粉吸入剂的药动学、药效学评价及其在肺泡部位的转运过程研究,中山大学大学生创新训练计划项目,2015.1-2016.1


论著专利

代表性专著:

1. Ming Lu. Chapter 9. Novel Excipients and Materials Used in 3D Printing of Pharmaceutical Dosage Forms. 3D and 4D Printing in Biomedical Applications: Process Engineering and Additive Manufacturing. Editor: Mohammed Maniruzzaman. Publisher: John Wiley, UK 2018 (in print).

 

2. Ming Lu. Chapter 10: Continuous cocrystallization of poorly soluble APIs to enhance dissolution. Practical Guide to Hot-Melt Extrusion: Continuous Manufacturing and Scale-Up Methodologies. Editor: Mohammed Maniruzzaman. Publisher: SmithersRapra, UK, 2015.

 

 

代表性论文:

1.       Xizhen Li1, Bingquan Wang1, Ziyuan Xie, Ming Lu*. Nicotinamide: Five new polymorphs discovered in melt-crystallization. Crystal Growth & Design, 2018 (under review).

2.       Zhengwei Huang, Ling Lin, Cushla McGoverin, Hu Liu, Lili Wang, Qi (Tony) Zhou, Ming Lu*, Chuanbin Wu. Dry powder inhaler formulations of poorly water-soluble itraconazoleA balance between in-vitro dissolution and in-vivo distribution is necessary. International Journal of Pharmaceutics, 2018 (under review).

3.       Yongcheng Li, Ming Lu*, Chuanbin Wu**. PVP VA64 as a novel release-modifier for sustained-release mini-matrices prepared via hot melt extrusion. Drug Delivery and Translation Research. 2017, 10.1007/ https://doi.org/ s13346-017-0437-9. (IF: 3.094)

4.       Ling Lin, Guilan Quan, Tingting Peng, Zhengwei Huang, Vikramjeet Singh, Ming Lu*, Chuanbin Wu**. Development of fine solid-crystal suspension with enhanced solubility, stability, and aerosolization performance for dry powder inhalation. International Journal of Pharmaceuticals. 2017, 533(1): 84-92. (IF: 3.649)

5.       Ming Lu, Lynne S. Taylor. Vemurafenib: A tetramorphic system displaying concomitant crystallization from the supercooled liquid. Crystal Growth & Design, 2016, 16 (10): 6033–6042. (IF: 4.425)

6.       Pin Dong, Ling Lin, Yongcheng Li, Zhengwei Huang, Tianqun Lang, Chuanbin Wu*, Ming Lu**. In-situ synchrotron wide-angle X-ray diffraction as a rapid method for cocrystal/salt screening. International Journal of Pharmaceutics. 2015, 496(1): 107-116. (IF: 3. 3.649) 

7.       Ming Lu, Zhefei Guo, Yongcheng Li, Huishi Pang, Ling Lin, Xin Pan*, Chuanbin Wu**. Application of hot melt extrusion for poorly water-soluble drugs: Limitations, Advances and Future prospects. Current Pharmaceutical Design. 2014, 20(3):369-387. (IF: 3.052)

8.       Zhefei Guo, Ming Lu*, Yongcheng Li, Huishi Pang, Ling Lin, Xu Liu, Chuanbin Wu**. The utilization of drug-polymer interactions for improving the chemical stability of hot-melt extruded solid dispersions. Journal of Pharmacy and Pharmacology. 2014, 66(2): 285–296.IF: 2.363

9.       Yongcheng Li, Huishi Pang, Zhefei Guo, Ling Lin, Yixuan Dong, Ge Li, Ming Lu*, Chuanbin Wu. Interactions between drugs and polymers influencing hot melt extrusion. Journal of Pharmacy and Pharmacology. 2014, 66(2): 148-166. (IF: 2.363)

10.   Yuefang Zhao, Yuting Qin, Yang Liang, Haijuan Zou, Xiao Peng, Huan Huang, Ming Lu, Min Feng*.Salt-induced stability and serum-resistance of polyglutamate polyelectrolyte brushes/nuclear factor-κB p65 siRNA polyplex enhance the apoptosis and efficacy of doxorubicin. Biomacromolecules. 2013, 14(6): 17771786. (IF: 5.583)

11.   Xu Liu, Ming Lu*, Zhe fei Guo, Lin Huang, Xin Feng, Chuanbin Wu**. Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion. Pharmaceutical Research. 2012, 293):806-817. ( IF: 3.260)

12.   Ming Lu, Xiang Zhao, Lan Chen, Xiaomin Xiong, Jingxiu Zhang, Kancheng Mai*, Chuanbin Wu**. Nucleation effect on polymorphism of melt-crystallized syndiotactic polystyrene. Polymer. 2011, 52(4): 1102-1106. (IF: 3.684)

13.   Ming Lu, Weihua Zhou, Kancheng Mai*. Effect of nano-CaCO3 on polymorphic behavior in syndiotactic polystyrene for non-isothermal crystallization. Polymer, 2006, 47: 1661-1666. (IF: 3.684)

14.   Ming Lu, Weihua Zhou, Kancheng Mai*. Syndiotactic Polystyrene/Nano- CaCO3 Composites, Key Engineering Materials. 2007, 335: 725-728.

15.   Weihua Zhou, Ming Lu, Kancheng Mai*. Isothermal crystallization, melting behavior and crystalline morphology of syndiotactic polystyrene blends with highly-impact polystyrene. Polymer. 2007, 48:3858-3867. (IF: 3.684)

授权专利

1. 吴传斌, 刘旭, 陆明. 一种难溶性药物共晶固体分散体及其制备方法专利号CN 102188365 B。(授权日期:2012125日)

2. 吴传斌,陆明,郭喆霏.二氟尼柳固体分散体及其制备方法。专利号:CN 103202811A。(授权日期:2015415日)

3. 吴传斌,陆明,黎永诚。富马酸喹硫平缓释制剂及其制备方法。专利号:ZL201410232678.2。(授权日期:2017103日)

4. 吴传斌,林玲,陆明。伊曲康唑吸入粉雾剂及其制备方法。专利号:CN 104398497B。(授权日期:20171124日)

5. 吴传斌,董品,陆明 伊曲康唑的固体分散体制备方法和应用。专利号:201510460617.6(授权日期:201825)