药理学

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李 民 [副教授,博士生导师]

李  民

联系方式

办公电话:020-39943036

电子邮箱:limin65@mail.sysu.edu.cn

办公地址:药学院

简单介绍

李民,中山大学“百人计划二期”引进人才,副教授,博士生导师。2007年博士毕业于清华大学生物学专业,2007-2012匹兹堡大学和印第安纳大学博士后和研究助理教授。目前在药学院药理专业从事教学和科研工作,主要开展新药筛选及药理学评价、细胞自噬与疾病的发生机制及相关调节剂研究,主持国家自然科学基金面上项目、广东省自然科学基金等在内的各类科研项目多项,在重要学术期刊Autophagy,Cell Death and Disease,J. Biol. Chem.等发表学术论文30余篇。

教学情况

药理学

药理学实验

药理学进展

病理生理学

药物筛选技术与进展

社会/学术任职

广东省药理学会新药筛选与评价专业委员会,常务委员

科研项目

国自然面上项目(2017-2020)

省自然项目 (2013-2015,2016-2018)

教育部留学回国人员启动基金 2013

教育部博士点新教师基金 2013

百人计划项目启动基金 2013

论著专利

1.Ying Gao, Yajun Liu, Liang Hong, Zuolong Yang, Xinran Cai, Xiaoyun Chen, Yuanyuan Fu, Yujie Lin, Weijie Wen, Sitong Li, Xingguo Liu, Heqing Huang, Andreas Vogt, Peiqing Liu*, Xiao-Ming Yin* and Min Li*, Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy, Cell Death and Disease, 2016, 7, e2330
2.Ming Zhang, Wangsheng Sun, Gongming Zhu, Guangjun Bao, Bangzhi Zhang, Liang Hong*, Min Li*, Rui Wang*, Enantioselective dearomative arylation of isoquinolines, ACS Catalysis, 2016, 6, 5290-5294
3.Jingwei Zhou, Zuolong Yang, Fan Zhang, Hai-Bin Luo, Min Li*, Ruibo Wu*, A salt bridge turns off the foot-pocket in class-II HDACs, Physical Chemistry Chemical Physics, 2016, 18, 21246-21250
4.Shenglan Liu, Shaorui Chen, Min Li, Boyu Zhang, Peiye Shen, Peiqing Liu, Dandan Zheng, Yijie Chen, Jianmin Jiang*, Autophagy activation attenuates angiotensin II-induced cardiac fibrosis, Archives of Biochemistry and Biophysics, 2016, 590, 37-47
5.Jing Lu, Duanping Sun, Zhiping Liu, Min Li, Huiqi Hong, Cui Liu, Si Gao, Hong Li, Yi Cai, Shaorui Chen, Zhuoming Li, Jiantao Ye*, Peiqing Liu*, SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy, Translational Research, 2016, 172, 96-112
6.DJ Klionsky*, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ..., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 2016, 12, 1-222
7.Min Li*, Zuolong Yang, Laura L Vollmer, Ying Gao, Yuanyuan Fu, Cui Liu, Xiaoyun Chen, Peiqing Liu, Andreas Vogt, Xiao-Ming Yin*, AMDE-1 is a dual function chemical for autophagy activation and inhibition, PloS one, 2015, 10, e0122083
8.Si Gao, Hong Li, Xiao-jun Feng, Min Li, Zhi-ping Liu, Yi Cai, Jing Lu, Xiao-yang Huang, Jiao-jiao Wang, Qin Li, Shao-rui Chen, Jian-tao Ye*, Pei-qing Liu*, a-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction, Journal of Molecular and Cellular Cardiology, 2015, 79, 92-103
9.Jingwei Zhou, Min Li, Nanhao Chen, Shenglong Wang, Hai-Bin Luo, Yingkai Zhang*, Ruibo Wu*, Computational design of a time-dependent histone deacetylase 2 selective inhibitor, ACS Chemical Biology, 2015, 10, 687-692
10.Hui Gao, Xiao-jun Feng, Zhuo-ming Li, Min Li, Si Gao, Yan-hong He, Jiao-jiao Wang, Si-yu Zeng, Xue-ping Liu, Xiao-yang Huang, Shao-rui Chen*, Pei-qing Liu*, Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides, Archives of Biochemistry and Biophysics, 2015, 565, 76-88
11.Luciana I Gallo, Yong Liao, Wily G Ruiz, Dennis R Clayton, Min Li, Yong-Jian Liu, Yu Jiang, Mitsunori Fukuda, Gerard Apodaca*, Xiao-Ming Yin*, TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells, Molecular Biology of the Cell, 2014, 25, 3779-3797
12.Debra Akin, S Keisin Wang, Pouran Habibzadegah-Tari, Brian Law, David Ostrov, Min Li, Xiao-Ming Yin, Jae-Sung Kim, Nicole Horenstein, William A Dunn Jr*, A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors, Autophagy, 2014, 10, 2021-2035
13.Luankun Zhang, Yanfang Chen, Zhongbao Yue, Yanhong He, Jian Zou, Shaorui Chen, Min Li, Xi Chen, Zhiping Liu, Xueping Liu, Xiaojun Feng, Min Li, Peiqing Liu*, The p65 subunit of NF-κB involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes, Archives of Biochemistry and Biophysics, 2014, 554, 22-27
14.Xi Chen, Bilon Khambu, Hao Zhang, Wentao Gao, Min Li, Xiaoyun Chen, Tamotsu Yoshimori, Xiao-Ming Yin*, Autophagy induced by calcium phosphate precipitates targets damaged endosomes, Journal of Biological Chemistry, 2014, 289, 11162-11174
15.Si Gao; Hong Li; Yi Cai, Jian-tao Ye; Jing Lu; Xiao-yang Huang; Xiao-jun Feng; Zhi-ping Liu; Shao-rui Chen,Min Li*, and Peiqing Liu*, Mitochondrial binding of α-enolase stabilizes mitochondrial membrane: its role in doxorubicin-induced cardiomyocyte apoptosis, Archives of Biochemistry and Biophysics, 2014, 542, 46-55
16.Min Li, Bilon Khambu, Hao Zhang, Jeong-Han Kang, Xiaoyun Chen, Daohong Chen, Laura Vollmer, Pei-Qing Liu, Andreas Vogt and Xiao-Ming Yin*, Suppression of lysosome function induces autophagy via a feedback downregulation of MTORC1 activity, Journal of Biological Chemistry, 2013, 288, 35769-35780
17.Chih-Wen Lin, Hao Zhang, Min Li, Xiwen Xiong, Xi Chen, Xiaoyun Chen, X. Charlie Dong and Xiao-Ming Yin*, Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice, Journal of Hepatology, 2013, 58, 993-999
18.Daohong Chen, Xi Chen, Min Li, Hao Zhang, Wen-Xing Ding, Xiao-Ming Yin*. CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable, Biochemical and Biophysical Research Communications,2013, 432, 226-230
19.Xi Chen, Min Li, Daohong Chen, Wentao Gao, Jun-Lin Guan, Massaki Komatsu and Xiao-Ming Yin*. Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis, PloS One, 2012, 7(12): e52347. doi:10.1371/journal.pone.0052347
20.Wen-Xing Ding, Min Li, Joanna M. Biazik, David G. Morgan, Fengli Guo, Hong-Min Ni, Michael Goheen, Eeva-Liisa Eskelinen, and Xiao-Ming Yin*. Electron Microscopic Analysis of a Spherical Mitochondrial Structure, Journal of Biological Chemistry, 2012, 287, 42373-42378
21.Min Li, Xi Chen, Qi-Zhuang Ye, Andreas Vogt and Xiao-Ming Yin*. A High-throughput FRET-based Assay for Determination of Atg4 Activity, Autophagy, 2012, 8,401-412
22.Jeong-han Kang, Min Li, Xi Chen and Xiao-Ming Yin*, Proteomics analysis of starved cells revealed Annexin A1 as an important regulator of autophagic degradation, Biochemical and biophysical research communications, 2011, 407, 581-586
23.Min Li, Yifeng Hou, Wang Jinsong, Xiaoyun Chen, Zhi-Ming Shao and Xiao-Ming Yin*, Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates, Journal of Biological Chemistry, 2011, 286, 7327-7338
24.Wen-Xing Ding, Min Li, and Xiao-Ming Yin*, Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets, Autophagy, 2011, 7, 248-249
25.Wen-Xing Ding, Min Li, Xiaoyun Chen, Hong-Min Ni, Chie-Wen Lin, Wentao Gao, Binfeng Lu, Donna B. Stolz, Dahn L. Clemens and Xiao-Ming Yin*, Autophagy reduces acute ethanol induced hepatotoxicity and steatosis in mice, Gastroenterology, 2010, 139, 1740-1752
26.Wen-Xing Ding, Hong-Min Ni, Min Li, Yong Liao, Xi Chen, Donna B. Stolz, Gerald W. Dorn II and Xiao-Ming Yin*, Nix is critical to two distinct phases of mitophagy: reactive oxygen species-mediated autophagy induction and parkin-ubiqutin-p62-mediated mitochondria priming, Journal of Biological Chemistry, 2010, 285, 27879-27890

其他

本课题组招收特聘研究员、副研究员及博士后人员,欢迎对自噬发生机制、自噬在疾病调控中的作用、新药筛选等方向感兴趣。直接联系本人。

欢迎研究生报考!