药物化学

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黄 玲 [副教授]

黄  玲

联系方式

办公电话:

电子邮箱:HuangL72@mail.sysu.edu.cn

办公地址:广州大学城中山大学药学院大楼510办公室

简单介绍

黄玲,副教授。广东省科技创新“青年拔尖人才”、广州市“珠江科技新星”。 专注于多靶点抗阿尔茨海默病药物分子设计合成及活性研究。研究成果在J. Med. Chem,ACS Chem. Neurosci等SCI 期刊上发表论文论文60余篇,其中第一作者或通讯(共同通讯)作者发表SCI研究论文34篇(J. Med. Chem 7篇),累计被引用超过1100余次,个人h-index为20。主持国家自然科学基金面上项目,青年科学基金、广东省自然科学基金等10余项课题。

研究方向

多靶点抗阿尔茨海默病(AD)药物分子设计合成、活性及作用机制研究

教育经历

2006.09~2011.06:中山大学药学院,博士;

2000.09~2004.06:中南大学药学院,本科

工作经历

2016.02~2017.02:Scripps研究所,访问学者;

2015.01~至今:中山大学药学院,副教授;

2011.06~2014.12:中山大学药学院,讲师(师资博士后);

科研项目

  1. 国家自然科学基金面上项目: 新型多靶点抗阿尔茨海默病喹啉衍生物:设计合成、生物活性与分子机制研究,项目负责人,64.0万元, 2018.01 - 2021.12 。

  2. 广东省“特支计划”科技创新青年拔尖人才,项目负责人,30.0万元,2016.05 - 2019.05

  3. 广州市珠江科技新星专项,项目负责人,30.0万元,2016.05 - 2019.05

  4. 广东省自然科学基金面上项目:多靶点抗阿尔茨海默病药物分子设计合成、活性研究及作用机制探索; 项目负责人,10.0万元,2015.01-2018.01

  5. 中山大学高校基本科研业务费青年教师培育项目:靶向Aβ神经毒性机制网络的苯并异硒唑酮喹啉衍生物的设计合成及其抗阿尔茨海默病作用研究;项目负责人,15.0万元, 2015.04 - 2018.04

  6. 国家自然科学基金青年基金:基于多靶点策略的茚酮衍生物的设计合成与抗阿尔茨海默病活性及作用机制研究,项目负责人,25.0万元,2014.01 - 2016.12

  7. 教育部博士点基金(新教师类):白藜芦醇衍生物的设计、合成及多靶点抗AD活性研究,项目负责人,4.0万元,2013.01 - 2014.12

  8. 博士后基金面上资助项目:白藜芦醇衍生物的设计、合成及多靶点抗AD活性研究,项目负责人,5.0万元,2012.05 - 2014.05

  9. 广东省新药设计与评价重点实验室开放基金项目:多靶点抗AD药物分子设计合成及活性研究,目负责人,2.0万元,2014.01 - 2014.12

  10. 广东省教育厅优秀青年教师培育项目:白藜芦醇衍生物22d多靶点抗AD药效学研究及作用机制探索,项目负责人,1.5万元,2012.10 - 2014.10


论著专利

 

第一作者或通讯作者论文 (IF2016年度影响因子)

1.        Zhiren Wang, Jinhui Hu, Xiaoping Yang, Xing Feng, Xingshu Li, * Ling Huang, * and Albert S. C. Chan. Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline–Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer’s Disease. J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.7b01417. (IF: 6.259 )

2.        Shun Zhang, Baijiao An, Jiayan Li, Jinhui Hu, Ling Huang,* Xingshu Li * and Albert S. C. Chan. Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents. Org. Biomol. Chem., 2017, 15, 7404 – 7410. (IF: 3.524 )

3.        Jun Yan, Jie Chen, Shun Zhang, Jinhui Hu, Ling Huang,* and Xingshu Li*. Synthesis, Evaluation, and Mechanism Study of Novel IndoleChalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo. J. Med. Chem. 2016, 59, 5264−5283 (IF: 6.259 )

4.        Tao Su, Tianhua Zhang, Shishun Xie, JunYan, Yinuo Wu, Xingshu Li, Ling Huang,* and Hai-Bin Luo *. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease. Sci. Rep. 2016, (6), 1-14. (IF: 4.259 )

5.        Zhiren Wang, Wenrui Li, Yali Wang, Xiruo Li, Ling Huang,* Xingshu Li*. Design, synthesis and evaluation of clioquinol-ebselen hybrids as multi-target-directed ligands against Alzheimer's disease. RSC Adv. 2016, 7139-7158. (IF: 3.108 )

6.        Yali Wang, Yang Sun, Yueyan Guo, Zechen Wang, Ling Huang*, Xingshu Li. Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer’s disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives. J. Enzyme. Inhib. Med. Chem.  2016, 31(3), 389-397. (IF: 4.293 )

7.        Zhiren Wang, Yali Wang, Bo Wang, Wenrui Li, Ling Huang,* and Xingshu Li*. Design, Synthesis and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multi-Target-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease. J. Med. Chem. 2015, 8616–8637. (IF: 6.259 )

8.        Zhiren Wang, Yali Wang, Wenrui Li, Zhihong Liu, Zonghua Luo, Yang Sun, Ruibo Wu, Ling Huang,* and Xingshu Li*. Computer-assisted designed “selenoxy–chinolin”: a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation. Dalton Trans., 2015, 44, 20913-25. (IF: 4.029)

9.        Jun Yan, Yueyan Guo, Yali Wang, Fei Mao, Ling Huang*, ,Xingshu Li *. Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. Eur. J. Med. Chem. 2015, 95, 220-229. (IF: 4.519 )

10.    Jun Yan, Yanqing Pang, Jie Chen, Jianfei Sheng, Jinhui Hu, Ling Huang,* and Xingshu Li*. Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents. RSC Adv. 2015, 98527-98537.  (IF: 3.108 )

11.    Jie Chen, Jun Yan, Jinhui Hu, Yanqing Pang, Ling Huang*, Xingshu Li*. Synthesis, Biological Evaluation and Mechanism Study of Chalcone Analogues as Novel Anti-cancer Agents. RSC Adv. 2015, 5, 68128-68135. (IF: 3.108 )

12.    Shishun Xie, Jie Chen, Xiruo Li, Tao Su, Yali Wang, Zhiren Wang, Ling Huang*, Xingshu Li*. Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease. Bioorg. Med. Chem., 2015, 23,  3722–3729. (IF: 2.930 )

13.    Jinhui Hu, Jun Yan, Jie Chen, Yangqing Pan, Ling Huang*, ,Xingshu Li *.Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents. MedChemComm., 2015,6, 318-1327. (IF: 2.608 )

14.    Tao Su, Shishun Xie, Bifu Li, Jun Yan, Ling Huang,* Xingshu Li*. Copper-catalyzed three-component one-pot synthesis of substituted 2-aryl-1,3-benzoselenazoles. Synlett. 2015, 26, 215-220. (IF: 2.151 )

15.    Fei Mao, Jianheng Li, Hui Wei, Ling Huang,* Xingshu Li*. Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease. J. Enzyme. Inhib. Med. Chem. 2015, 995-1001. (IF: 4.293 )

16.    Zhiren Wang , Yali Wang, Wenrui Li, Fei Mao, Yang Sun, Ling Huang*, ,Xingshu Li *. Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease. ACS Chem. Neurosci. 2014, 5, 952− 962. (IF: 3.883 )

17.    Jianfei Sheng, Fei Mao, Jun Yan , Ling Huang *, Xingshu Li*.The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents. RSC Adv., 2014, 4, 41510 - 41520. (IF: 3.108 )

18.    Ling Huang, Hui Miao, Yang Sun, Fanchao Meng, Xingshu Li*. Discovery of indanone derivatives as multi-target-directed ligands against Alzheime r's disease. Eur. J. Med. Chem. 2014, 87, 429 - 439. (IF: 4.519 )

19.    Ling Huang, Wenjun Shan, Qi Zhou, Jiaxing Xie, Kefang Lai, Xingshu Li*. Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Bioorg. Med. Chem. Lett. 2014, 24, 249–253. (IF: 2.454 )

20.    Fei Mao, Jun Yan, Jianheng Li, Xian Jia, Hui Miao, Yang Sun, Ling Huang* , Xingshu Li*. New multi-target-directed small molecules against Alzheimer ’ s disease: a combination of resveratrol and clioquinol. Org. Biomol. Chem., 2014, 12, 5936 –5944. (IF: 3.524 )

21.    Chuanjun Lu, Yueyan Guo, Jun Yan, Zonghua Luo, Hai-Bin Luo, Ming Yan, Ling Huang*, Xingshu Li*. Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer's Disease. J. Med. Chem. 2013, 56(14), 5843−5859 (IF: 6.259 )

22.    Zonghua Luo , Jianfei Sheng, Yang Sun, Chuanjun Lu, Jun Yan, Anqiu Liu, Hai-Bin Luo, Ling Huang*, Xingshu Li*. Synthesis and evaluation of multi-target-directed ligands against Alzheimer’s disease based on the fusion of donepezil and ebselen. J. Med. Chem. 2013, 56, 9089− 9099. (IF: 6.259 )

23.    Ling Huang, Tao Su, Xingshu.Li*. Natural Products as Sources of New Lead Compounds for the Treatment of Alzheimer's Disease. Curr. Top. Med. Chem. 2013, 13(15), 1864-1878. (IF: 2.561 )

24.    Chuanjun Lu , Qi Zhou, Jun Yan, Zhiyun Du, Ling Huang*, Xingshu Li*. A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer’s disease. Eur. J. Med. Chem. 2013, 62, 745-753. (IF: 4.519 )

25.    Tao Su, Shishun Xie, Hui Wei, Jun Yan, Ling Huang*, Xingshu Li*.Synthesis and biological evaluation of berberine–thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. Bioorg. Med. Chem. 2013, 21(18), 5830–5840. (IF: 2.930 )

26.    Yang Sun, Jianwen Chen, Xuemin Chen, Ling Huang*, Xingshu Li*. Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine–Homoisoflavonoid hybrids. Bioorg. Med. Chem. 2013, 21(23), 7406–7417. (IF: 2.930 )

27.    Ling Huang, Chuanjun Lu, Yang Sun, Fei Mao, Zonghua Luo, Tao Su, Huailei Jiang, Wenjun Shan, Xingshu Li*. Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease. J. Med. Chem. 2012, 55(19), 8483− 8492. (IF: 6.259 )

28.    Ling Huang, Su Tao, Wenjun Shan, Zonghua Luo, Yang Sun and Xingshu Li*. Inhibition of Cholinesterase activity and Amyloid aggregation by Berberine- phenyl-benzoheterocyclic and Tacrine-phenyl-benzoheterocyclic hybrids. Bioorg. Med. Chem. 2012, 20(9), 3038-3048. (IF: 2.930 )

29.    Meng, Fan-Chao, Mao, Fei; Shan, Wen-Jun; Qin, Fangfei; Huang, Ling*, Li Xing-Shu*. Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents, Bioorg. Med. Chem. Lett., 2012, 22(13), 4462–4466. (IF: 2.454 )

30.    Ling Huang, Anding Shi, Feng He, Xingshu Li. Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg. Med. Chem. 2010, 18, 1244-1251. (IF: 2.930 )

31.    Ling Huang, Zonghua Luo, Feng He, Jing Lu, Xingshu Li. Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg. Med. Chem. 2010, 18(12), 4475-4484. (IF: 2.930 )

32.    Ling Huang, Zonghua Luo, Feng He, Anding Shi Fangfei Qin and Xingshu Li. Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. Bioorg. Med. Chem. Lett. 2010, 20(22), 6649–6652. (IF: 2.454 )

33.    Ling Huang, Juntao Liu, Wenjun Shan, Bao Liu, Anding Shi, Xingshu Li .The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with poly ethylene glycol bound Rh catalyst in PEG2000 and water. Chirality. 2010, 22(2), 206-211. (IF: 1.956 )


获奖情况

  1. 广东省科技创新“青年拔尖人才”、(2015);

  2. 广州市珠江科技新星(2015);