药理学

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黄民 [教授,博士生导师]

黄民

联系方式

办公电话:020- 39943011

电子邮箱:huangmin@mail.sysu.edu.cn

办公地址:中国广州大学城外环东路132号,邮编:510006

简单介绍

黄民,男,1963年10月生,二级教授,博士生导师。中山大学临床药理研究所所长,享受国务院政府特殊津贴专家。

 

研究方向

黄民教授的主攻研究领域是临床药理学和药代动力学,对相关药物代谢酶和转运蛋白及其上游调控因子的基因多态性及其与临床药物相互作用及临床合理用药方面有较深入研究。近5年,结合基因组学、表观遗传学、代谢组学、肠道微生物组学等技术手段,全面筛查与华法林、氯吡格雷、阿司匹林、他克莫司、环孢素、环磷酰胺、霉酚酸类药物、硫嘌呤类药物、丙戊酸、拉莫三嗪、吉非替尼、伊马替尼等个体化用药相关的“生物标志物”,构建了剂量预测模型以及不良反应预测模型,并已在临床指导华法林、他克莫司、环磷酰胺、硫嘌呤类药物个体化用药,相关研究成果发表在J Hepatol、Cell Death Differ、Aliment Pharmacol Ther、Cell Death Dis、Br J Pharmacol、Carcinogenesis、 Inflamm Bowel Dis、 Int J Neuropsychopharmacol、Drug Metab Dispos、Pharmacogenomics J等杂志。发表SCI论文100余篇,主编/参编著作10余部,申请相关专利30多项。

教育经历

1979.9—1983.6   上海医科大学本科学习,获学士学位;

1985.9--1988.6    中山医科大学药理学研究生,获硕士学位;

1994.10—1998.8   香港大学获药理学博士研究生。

工作经历

1983.6—1989.11  中山医科大学临床药理教研室助教;

1989.12—1994.11 中山医科大学临床药理教研室讲师;

1994.12—2000.11 中山医科大学临床药理教研室副教授;

2002.6—2016.08  中山大学药学院常务副院长、院长;

2000.12 — 现在   中山大学临床药理研究所教授、所长。

社会/学术任职

担任国家药典委员、国务院学位委员会第七届药学学科评议组成员、中国药理学会常务理事、临床药理专业委员会主任委员、药物代谢专业委员会委员(理事)、International Society for the Study of Xenobiotics(ISSX)财经委员会委员、广东省科协常委、广东省药理学会名誉理事长、广东省药学会副理事长、广东省药物评价及合理用药专业委员会主任委员;“Drug Metabolism and Disposition ”、“中国药学英文版”、 “药学学报”、“中国临床药理学杂志”、“中国医药工业杂志”、“中药新药与临床药理” 、“中国临床药理学与治疗学杂志”、“中国药学杂志英文版”、“今日药学”杂志编委;国家食品药品监督管理总局药品审评专家库专家、广东省药品审评专家库专家。

科研项目

1. 冠心病个体化用药靶标发现与组学新技术研发(国家重点研究计划项目,400万圆,2017~2019,项目编号 2017YFC0909300);

2. 基于多组学的丙戊酸钠个体化给药方案的生物标志物的发现与确证(国家自然科学基金重点项目,280万圆,2018~2022,项目编号81730103

3. 重大疾病新靶点与药物研究创新引智基地(111计划,900万圆,2016-2020,基地编号B16047);

4. 基于基因组学和代谢组学的硫嘌呤类药物个体化给药(国家自然科学基金,58万圆,2016.01-2019.12,项目编号81573507);

5. 基于药物基因组学及表观遗传调控的环孢素/他克莫司个体化用药研究((国家自然国际合作项目,280万圆,2014.01-2018.12,项目编号81320108027

6. 红豆杉口服抗肿瘤5类新药的开发研究(广东省重大科技专项,150万圆2013.01-2014.04,项目编号2012A080202013

7. 个体化用药相关重要生物技术标志物及其新型检测试剂盒研发关键技术(十二五重大专项,500万圆,2012.01~2015.12,项目编号2012ZX09506001-004

8. 广东省新药设计与评价重点实验室(广东省科技计划,500万圆,2011年,项目编号2011A060901014

9. 多基因 “网络”调控作用下环孢素/他克莫司个体化用药研究.(国家自然科学基金,37万圆,2011.012013.12,项目编号81072708

10. 临床前药物代谢动力学技术平台.国家“重大新药创制”科技重大专项1500 万圆,负责330万圆,2009.012010.12,项目编号2009ZX09304-003

11. 新药临床评价研究技术平台.国家“重大新药创制”科技重大专项1200 万圆,负责166万圆,2008.012010.12,项目编号2008ZX09312

12. 相关代谢酶基因多态性与环磷酰胺在SLE病人中疗效和不良反应相关性研究国家自然科学基金32 万圆,2009.012011.12,项目编号30873124

13. 器官移植患者相关基因单倍型多态性与免疫抑制剂个体化作用(广东省科技计划项目基金,4 万圆,2007年,项目编号2007B031511001

14. 创新药物研究筛选与评价科技创新平台建设(教育部II985重点建设专项,2200万圆,2005年,平台负责人)

15. 应用TPMT表型及基因型指导硫嘌呤类药物的临床使用(国家自然科学基金,28万圆,2005年,项目编号30572231

16. 广州新药临床前评价研究技术平台(广州市重大项目,500万圆,2004,项目编号2004Z1-E4051

17. 中华民族硫嘌呤甲基转移酶基因多态性研究(教育部博士点基金,6万圆,2003年,项目编号20030558081

18. 应用硫嘌呤甲基转移酶基因型预测嘌呤类药物毒性疗效广东省自然科学基金重点项目,15万圆,2003年,项目编号36622

19. 临床试验关键技术及平台研究(863)(国家科技部,150万圆,2002年,分题负责)

20. TPMT基因多态性与硫嘌呤类毒性和疗效关系(国家自然科学基金,16万圆, 2001年,项目编号30171098

 


论著专利

论述:

1. 普通高等教育“十二五”规划教材《临床药理学》,清华大学出版社,2012.01. (副主编);

2. 普通高等教育“十一五”国家规划教材 案例版《临床药物代谢动力学》,科学出版社,2009.12.(副主编)

3. 普通高等教育“十一五”国家级规划教材《临床药理学》,高等教育出版社,2010.01(参编)

4. 《英汉化学药物词典》,商务出版社,2010.03.(主编)

5. 临床药理学》,中山大学出版社.2007.08.(主编)

6. 药物临床试验标准操作规程实用指南》,广东科技出版社 2004.10.(主编)

7. 临床药代动力学基础与应用》,郑州大学出版社2002.11.(副主编)

8. 药理学》,北京大学医学出版社2004.04.(参编)

9. 高新技术科普丛书《量体裁药不是梦——从基因到个体化用药》,广东科技出版社,2011.05.(主编)

10. 普通高等教育“十一五”国家级规划教材《临床药物代谢动力学》,科学出版社,2016(副主编)

11. 国家卫生和计划生育委员会“十二五”规划教材、全国高等医药教材建设委员会“十二五”规划教材、全国高等学校临床药学专业第二轮规划教材《临床药理学》,人民卫生出版社,2014.10(参编)

12. 《临床药理学》,中山大学出版社,2017.07. (主编)

13. 高等院校 “十三五”规划/创新实验教材《药代动力学实验教程》,中山大学出版社,2017.04, (主编)

14. 全国高等医药院校“十三五”规划教材《临床药理学》,高等教育出版社,2017.07. (参编)

 

近三年发表的论文:

1. Zhuang W, Qiu HB, Chen XM, Yuan XH, Yang LF, Sun XW, Zhou XJ, Huang M, Wang XD*, Zhou ZW*. Simultaneous quantification of imatinib and its main metabolite N-demethyl-imatinib in human plasma by liquid chromatography-tandem mass spectrometry and its application to therapeutic drug monitoring in patients with gastrointestinal stromal tumor. Biomedical Chromatography,2017,31(12):1-11.

2. Li JL, Chen SY, Qin XL, Fu Q, Bi HC, Zhang Y, Wang XD, Liu LS, Wang CX*, Huang M*. Wuzhi Tablet (Schisandra sphenanthera Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study. Drug Metabolism and disposition,2017,45(11):1114-1119.

3. Li X, Sun JH, Fan XM, Guan LH, Li DS, Zhou YW, Zeng XZ, Chen YX, Zhang HZ, Xu LQ, Jiang FL, Huang M, Bi HC*. Schisandrol B promotes liver regeneration after partial hepatectomy in mice. European journal of pharmacology,818:96-102.

4. Deng Y, Zhuang JL, Wu JG, Chen JY, Ding L, Wang XD, Huang LH, Zeng GX, Chen J, Ma ZF, Chen X, Zhong GP*, Huang M, Zhao XL.A bioequivalence study of two memantine formulations in healthy Chinese male volunteers. International Journal of Clinical Pharmacology and Therapeutics.2017,55(10):832-838.

5. Qiu HB, Zhuang W, Wang XD, Huang M, Zhou ZW*. Association between genetic polymorphisms and variation of imatinib pharmacokinetics in gastrointestinal stromal tumors. Chinese journal of gastrointestinal surgery.2017,20(9):1031-1034.

6. Chen P, Li DS, Chen YX, Sun JH, Fu KL, Guan LH, Zhang HZ, Jiang YM, Li X, Zeng XZ, Chen X, Huang M, Bi HC*. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. British journal of pharmacology,2017,174(23):4345-4361.

7. Zhang HZ, Gao Y, Sun JH, Fan SC, Yao XP, Ran XR, Zheng CQ, Huang M, Bi HC*. Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells. Analytical and Bioanalytical Chemistry.2017,409(22):5349-5358.

8. Zeng XZ, Li X, Xu CS, Jiang FL, Mo YF, Fan XM, Li YT, Jiang YM, Li DS, Huang M, Bi HC*. Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta pharmaceutica Sinica. B.2017,7(5):583-592.

9. Chao K, Wang XD, Cao Q, Qian JM, Wu KC, Zhu, X, Yang H, Liang J, Lin L, Huang ZC, Zhang Y, Huang YB, Sun YH, Xue XM, Huang M, Hu, PJ, Lan P, Gao X*. Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis. Inflammatory Bowel Disease.2017,23(9):1582-1599.

10. Wang Y,Zhou C,Gao H,Li GX,Li D,Liu PQ,Huang M,Shen XY*,Liu L*.Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.Biochemical Pharmacology.2017 Aug,138:119-129.

11. Liang YB,Huang M,Jiang X,Liu Q,Chang X,Guo Y*.The neuroprotective effects of Berberine against amyloid β-protein-induced apoptosis in primary cultured hippocampal neurons via mitochondria-related caspase pathway.Neuroscience Letters.2017 Aug,

655:46-53.

12. Zhang HuizhenGao YueSun JiahongFan ShichengYao XinpengRan XiaorongZheng ChuanqiHuang Min*; Bi Huichang*.Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells.Analytical and bioanalytical chemistry.2017 Sept,409(22): 5349–5358.

13. Bai XP,Hong WP,Cai PH,Chen YB,Xu CC,Cao D,Yu WB,Zhao ZX,Huang Min,Jin J*.Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis.Toxicology and Applied Pharmacology.2017 June,324 :12–25.

14. Lu Liang,Zhang Sulin, Li Cuixian,Zhou Chun,Li Dong,Liu Peiqing,Huang Min,Shen Xiaoyan.Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.CELL DEATH & DISEASE.

2017 May,8:e2767.

15. Li Yuhua,Huang Ling,Sun Jiahong,Wei Xiaohua,Wen Jinhua,Zhong Guoping,Huang Min,Bi Huichang*.Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells.JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.2017 Sept,31(5):  e21884.

16. Hu Bingfang,Li Yujin,Gao Li,Guo Yan,Zhang Yiwen,Chai Xiaojuan,Xu Meishu,Yan Jiong,Lu Peipei,Ren Songrong,Zeng Su,Liu Yulan,Xie Wen,Huang Min*.Hepatic Induction of Fatty Acid Binding Protein 4 Plays a Pathogenic Role in Sepsis in Mice.AMERICAN JOURNAL OF PATHOLOGY.2017 Sept,187(5):  1059-1067.

17. Zeng Hang,Jiang Yiming,Chen Pan,Fan Xiaomei,Li Dongshun,Liu Aiming,Ma Xiaochao,Xie Wen,Liu Peiqing,Gonzalez Frank J,Huang Min*,Bi Huichang*.Schisandrol B protects against cholestatic liver injury through pregnane X receptors.BRITISH JOURNAL OF PHARMACOLOGY. 2017 Apr,174(8):  672-688.

18. Chen Yixin,Wang Yongtao,Huang Yaoyao,Zeng Hang,Hu Bingfang,Guan Lihuan,Zhang Huizhen,Yu Ai-Ming,Johnson Caroline H,Gonzalez Frank J,Huang Min,Bi Huichang.PPAR alpha regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C.CARCINOGENESIS. 2017 Apr,38(4):  474-483.

19. Wen Dingsheng,Guo Jing,Jiang Fulin,Huang Caishun,Zhao Zhenzhen,Lu Gui,Chen Jiangying,Qin Liuyun,Li Zhangwei,Wang Xueding,Deng Zhuoan,Huang Min,Chi Chan Albert Sun,On Tang Johnny Cheuk,Zhong Guoping.A rapid and sensitive UHPLC-MS/MS method for quantification of 83b1 in plasma and its application to bioavailability study in rats.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2017 Feb,134: 

71-76.

20. Ni, Guanzhong;Qin, Jiaming; Chen, Ziyi; Li, Hongliang; Zhou, Jueqian; Huang, Min; Zhou, Liemin. Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy. Clinical Nutrition, 2017 Jan,20.

21. Zhang, Huizhen; Jiang, Yiming ; Wu, Jingjing ; Zheng, Chuanqi; Ran, Xiaorong; Li, Dongshun; Huang, Min; Bi, Huichang. Metabolic mapping of Schisandra sphenanthera extract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high-resolution mass spectrometry. Journal of Separation Science, 2017, 40(2):574.

22. Li Yu-hua; Huang Ling; Wei Xiao-hua; Wen Jin-hua; Zhong Guo-ping; Huang Min; Bi Hui-chang.Regulation of P-glycoprotein gene expression by PKC/NF-κB-PXR signaling pathway. Acta Pharmaceutica Sinica. 2017,52(1): 51-57

23. Qin Li; Li Jiali; Liu Xiaoman; Chen Xutao; Liu Shu; Liu Longshan; Wang Changxi; Huang Min.Associations of VDR polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients. Acta Pharmaceutica Sinica. 2017,52 (5) :760-765

24. Peng Ling-ling, Zhao Yuan-qi, Zhou Zi-yi, Jin Jing, Zhao Min, Chen Xin-meng,Chen Ling-yan, Cai Ye-feng*, LI Jia-li*, Huang Min*. Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy. Acta Pharmacologica Sinica 2016: 1–7.

25. Chen Xin-meng, Zhao Zhong-xiang, Chen Yi-bei, Gou Xiao-li, Zhou Zi-yi, Zhong Guo-ping, Cai Ye-feng, Huang Min, Jin Jing *, Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology 192(2016)362–369.

26. Bai Xu-peng, Chen Yi-bei, Hou Xiang-yu, Huang Min * & Jin Jing *; Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters . Drug Metab Rev. 2016 Jun 20:1-27.

27. Wang Wen-wen, Guan Cui-wen, Sun Xiao-zhe, Zhao Zhong-xiang, Li Jia, Fu Xin-lu, Qiu Yu-wen, Huang Min, Jin Jing ∗, Zhi-ying Huang∗; Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway.  Phytomedicine. 2016 Jun 1;23(6):589-96.

28. Liu Rui , Zhou Zi-yi , Chen Yi-bei , Li Jia-li , Yu Wei-bang , Chen Xin-meng , Zhao Min , Zhao Yuan-qi , Cai Ye-feng *, Jin Jing *, and Huang Min *. Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke. Acta Pharmacol Sin. 2016 Jul;37(7):882-8.

29. Ma Y, Xin S, Huang M, Yang Y, Zhu C, Zhao H, Zhang Y, Chen L, Zhao Y, Li J, Zhuang W, Zhu X, Zhang L * and Wang X *. Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters. The pharmacogenomics journal 2016 Apr: 1–6.

30. Yu Tao, Wang Yong-tao, Zhang Hui-zhen, Caroline H. Johnson, Jiang Yi-ming, Li Xiang-jun, Wu Ze-ming, Liu Tian, Kristopher W. Krausz, Aiming Yu, Frank J. Gonzalez, Huang Min, Bi Hui-chang *.Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells. Anal Bioanal Chem. 2016 Jun;408(16):4267-73.

31. Zhao Zhen-zhen, Huang Ling-jie, Gou Xiao-li, Li Zhang-wei, Chen Jiang-ying, Wen Ding-sheng, Jiang Fu-lin, Lu Gui, Bi Hui-chang, Huang Min, Zhong Guo-ping *. Determination of a novel Aurora-A (AurA) kinase AKI603 by UPLC-MS/MS and its application to a bioavailability study in rat.  J Pharm Biomed Anal. 2016 Jun 5;125:303-9.

32. Tan Yin-he , Si Xiao-qing , Zhong Lu-lu , Feng Xin , Yang Xin-min , Huang Min *, and Wu Chuan-bin * Development and validation of dissolution testings in acidic media for rabeprazole sodium delayed-release capsules. Drug Dev Ind Pharm. 2016 Oct;42(10):1669-77.

33. Li Xi,  Fan Xiao-mei, Li Dong-shun, Zeng Xue-zhen, Zeng Hang, Wang Yong-tao, Zhou Ya-wen, Chen Yi-xin, Huang Min *, and Bi Hui-chang *. Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice. Drug Metab Dispos. 2016 May;44(5):647-52.

34. Xu Chen-shu,  Huang,Min, Bi Hui-chang *. PXR- and CAR-mediated herbal effect on human diseases. Biochim Biophys Acta. 2016 Sep;1859(9):1121-9.

35. Jiang Yi-ming, Wang Ying, Tan Hua-sen, Yu Tao, Fan Xiao-mei, Chen Pan, Zeng Hang, Huang Min,* and Bi Hui-chang *.Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway. Acta Pharmacol Sin. 2016 Mar;37(3):382-9.

36. Tan Hua-sen, Xu Chen-shu, Zeng Hang, Wang Ying, Li Ying-mei, Fan Xiao-mei, Chen Pan, Jiang Yi-ming, Chen Xiao, Huang Min *, Bi Hui-chang *. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells . J Pharmacol Sci. 2016 Feb;130(2):66-71.

37. Guo Yan, Hu Bing-fang, Xie Yang, Timothy R. Billiar,d Jason L. Sperry, Huang Min, and Xie Wen *. Regulation of drug-metabolizing enzymes by local and systemic liver injuries. Expert Opin Drug Metab Toxicol. 2016;12(3):245-51.

38. Zhao Z., Chen J., Peng W., Wang X., Chen Z., Tang H., Liang Y., Ma Z., Chen J., Chen X., Zhong G. *, Huang M.. Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection. Drug Res (Stuttg). 2016 May;66(5):251-6.

39. Zeng Hang, Li Dong-shun, Qin Xiao-ling, Chen Pan, Tan Hua-sen, Zeng Xue-zhen, Li Xi,  Fan Xiao-mei, Jiang Yi-ming, Zhou Ya-wen, Chen Yi-xin, Wang Ying, Huang Min *,and  Bi Hui-chang *. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration. Drug Metab Dispos.2016 Mar;44(3):337-42.

40. Shu Wen-ying, Guan Su, Yang Xiu-yan, Liang Liu-qin, Li Jia-li, Chen Zhuo-jia, Zhang Yu, Chen Ling-yan, Wang Xue-ding *, Huang Min *. Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus. Br J Clin Pharmacol. 2016 Feb;81(2):327-40

41. Zhu X, Wang XD*, Chao K, Zhi M, Zheng H, Ruan HL, Xin S, Ding N, Hu PJ, Huang M, Gao X*. NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease. Aliment Pharmacol Ther. 2016 Sep 8.

42. Chen Pan, Li Jingjie , Fan Xiao-mei , Zeng Hang, Deng Rong-rong , Li Dong-shun, Huang Min, Bi Hui-chang * ,Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism. Eur J Pharmacol. 2015 Oct 15;765:131-9.

43. Zhuang Jia-lang , Chen Jiang-ying, Wang Xue-ding , Pang Yin, Bi Hui-chang ,Huang Li-hui ,Zeng Gui-xiong , Liao Xiao-xing , Ma Zhong-fu, Chen Xiao ,Zhong Guo-ping* ,Huang Min ,Zhao Xiang-lan .Validation of a HPLC-ESI MS/MS method for the determination of clonidine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers. Biomed Chromatogr. 2015 Oct;29(10):1506-13.

44. Hu Bing-fang,  Guo Yan, Wojciech G. Garbacz, Jiang Meng-xi , Xu Mei-shu , Huang Hai , Allan Tsung, Timothy R. Billiar, Sadeesh K. Ramakrishnan, Yatrik M. Shah, Karen S.L. Lam, Huang Min *, Xie Wen *, Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury. J Hepatol. 2015 Oct;63(4):855-62.

45. Liu Hui *, Ding Liang,Zhang Fang-bin ,Zhang Yu ,Gao Xiang ,Hu Pin-jin , Bi Hui-chang, Huang Min , The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases. J Pharmacol Sci. 2015 Oct;129(2):95-100.

46. Jin Jing,Sun Xiao-zhe, Zhao Zhong-xiang, Wang Wen-wen, Qiu Yu-wen, Fu Xin-lu, Huang Min ,  Huang Zhi-ying*.Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity. Phytomedicine. 2015 Sep 15;22(10):894-901.

47. Ma Li-ping, QinYa-hong, Shen Zhuo-wei,Bi Hui-chang , Hu Hai-yong, Huang Min, Zhou Hui , Yu Lu-shan, Jiang Hui-di, Zeng Su*, .Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2. J Ethnopharmacol. 2015 Aug 22;172:430-5.

48. Chai Xiao-juan, Guo Yan, Jiang Meng-xi, Hu Bing-fang, Li Zhi-gang, Fan Jie , Deng Mei-hong, Timothy R. Billiar, Heidi R. Kucera, Nilesh W. Gaikwad, Xu Mei-shu, Lu Pei-pei, Yan Jiong,  Fu Hai-yan, Liu You-hua,Yu Lu-shan, Huang Min ,Zeng Su *, Xie Wen*.Oestrogen sulfotransferase ablation sensitizes mice to sepsis. Nat Commun. 2015 Aug 10;6:7979.

49. Zhou Ya-fang, Wang Xue-ding, Li Hong-liang, Zhang Jie, Chen Ziyi , Xie Wen, Zhang Jin-xin,  Li Jia-li, Zhou Lie-min * , Huang Min*. Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients. Drug Metab Pharmacokinet. 2015 Aug;30(4):282-7.

50. Xin Shuang, Zhao Yuan-yuan,Wang Xue-ding , Huang Yan, Zhang Jing , Guo Ying,Li Jia-li , Li Hong-liang, Ma Yu-xiang, Chen Ling-yan, Hu Zhi-huang, Huang Min,*, Zhang Li*. The Dissociation of Gefitinib Trough Concentration and Clinical Outcome in NSCLC Patients with EGFR Sensitive Mutations. Sci Rep. 2015 Jul 31;5:12675.

51. Wang Ying, Jiang Yi-ming, Fan Xiao-mei, Tan Hua-sen, Zeng Hang, Wang Yong-tao, Chen Pan, Huang Min , Bi Hui-chang*. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Toxicol Lett. 2015 Jul 16;236(2):82-9.

52. Wang Yi-xi , Li Jia-li, Wang Xue-ding ,Zhang Yu ,Wang Chang-xi *, Huang Min*. Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation. Acta Pharmacol Sin. 2015 Jul;36(7):855-62.

53. Li Mei-Mei, Balasubrahmanyam Addepalli, Tu  Mei-Juan,Chen  Qiu-Xia , Wang Wei-Peng, Patrick A. Limbach, Janine M. LaSalle, Zeng Su, Huang Min,  Yu Ai-Ming*. Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. Drug Metab Dispos. 2015 Jul;43(7):1129-36.

54. GuoYan, Hu Bing-fang,  Huang Hai, Allan Tsung, Nilesh W. Gaikwad*, Xu Mei-shu,Jiang  Meng-xi , Ren Song-rong, Fan Jie , Timothy R. Billiar, Huang Min*,  Xie Wen*. Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury. J Biol Chem. 2015 Jun 5;290(23):14754-64.

55. Wang Ying, Wang Shao-gui, Li Yan-mei, Jiang Jian-Min, Zhou Chun, Li Cui-xian, Li Dong,  Lu Liang, Liu  Pei-qing, Huang Min, Shen Xiao-yan* , Therapeutic effect of Cryptotanshinone on collagen-induced arthritis in rats via inhibiting nuclear factor kappa B signaling pathway. Transl Res. 2015 Jun;165(6):704-16.

56. Jin Jing, Li Mei, Zhao Zhong-xiang, Suna Xiao-zhe, Li Jia, Wang Wen-wen, Huang Min,  Huang Zhi-ying*. Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine. 2015 May 15;22(5):528-35.

57. Shu Wen-ying,Li Jia-li ,Wang Xue-ding , Huang Min *. Pharmacogenomics and personalized medicine: a review focused on their application in the Chinese population. Acta Pharmacol Sin. 2015 May;36(5):535-43.

58. Xie Xiao-chun , Li Jun, Wang Hong-yang, Li Hong-liang, Liu  Jing, Fu Qian, Huang Jia-wen,  Zhu Chen,  Zhong Guo-ping, Wang Xue-ding,Sun  Ping-ping , Huang Min ,  Wang Chang-xi*, Li Jia-li *. Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients. Acta Pharmacol Sin. 2015 May;36(5):644-50.

59. Hou Xiang-yu, Bai Xu-peng, Gou Xiao-li, Zeng Hang, Xia Chen, Zhuang Wei, Chen Xin-meng,  Zhao Zhong-xiang, Huang Min, Jin  Jing*. 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway. Mol Cells. 2015May;38(5):396-401.

60. Jiang Yi-ming, Fan  Xiao-mei,Wang Ying , Tan Hua-sen, Chen Pan, Zeng Hang, Huang Min*,  Bi Hui-chang*. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chem Biol Interact. 2015 Apr 25;231:83-9.

61. Liu Xiao-man,Li  Jia-li , Fu  Qian, Liu Shu, Zhang Yu, Wang Xue-ding,Wang Hong-yang ,  Li Jun,Zhu Chen , Wang Chang-xi*, Huang Min*. Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy. Drug Metab Dispos. 2015 Apr;43(4):455-8.

62.  Liu Bin , Gou  Xiao-li, Bai Xu-peng, Hou Xiang-yu, Li Dong-shun, Zhong Guo-ping, Jin Jing*,  Huang Min*. Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts. J Pharm Biomed Anal. 2015 Mar 25;107:346-54.

63. Li Hong-liang, Wang  Xue-ding, Zhou Ya-fang, Ni Guan-zhong , Su  Qi-biao, Chen Zi-yi,  Chen Zhuo-jia, Li Jia-li , Chen Xin-meng , Hou Xiang-yu, Xie Wen, Xin Shuang,,Zhou  Lie-min, Huang Min *. Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. Int J Neuropsychopharmacol. 2015 Mar 3;18(7):pyv021.

64.  Huang Na, Situ  Bing, Chen Xiao, Liu Jianqiao, Yan Peng-ke, Kang Xin-huang, Kong Song-zhi,  Huang Min*.  Meta-analysis of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril. 2015 Feb;103(2):367-73.e5.

65.  Xia Chen , Bai Xu-peng , Hou Xiang-yu , Gou Xiao-li , Wang Yong-tao , Zeng Hang, Huang Min ,Jin Jing *. Cryptotanshinone Reverses Cisplatin Resistance of Human Lung Carcinoma A549 Cells through Down-Regulating Nrf2 Pathway. Cell Physiol Biochem. 2015;37(2):816-24.

66. Yu Tao, Wang Yong-Tao, Chen Pan, Li Yu-Hua, Chen Yi-Xin, Zeng Hang, Yu Ai-Ming, Huang Min, Bi Hui-Chang*. Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress. Cell Physiol Biochem. 2015;35(2):710-21.

67. Zuo Zhong*, Huang Min,  Isadore Kanfer,  Moses S. S. Chow,  William C. S. Cho . Herb-drug interactions: systematic review, mechanisms, and therapies. Evid Based Complement Alternat Med. 2015 Feb;2015:239150.

68.  Li Jia-li, Liu  Shu, Fu  Qian, Zhang Yu , Wang Xue-ding, Liu Xiao-man, Liu Long-shan,  Wang Chang-xi, Huang Min*.  Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant crecipients. Pharmacogenomics. 2015 August;16(12):1355-65.

69. 46. Ni Guan-zhong,Qin Jia-ming, Li Hongliang, Chen Ziyi, Zhou Yafang, Fang Ziyan, ChenYi-shu , Zhou Jue-qian, Huang Min, Zhou Lie-min*. Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy. PLoS One. 2015 Apr 27;10(4):e0125656.

Jiang Yi-ming, Fan Xiao-mei, Wang Ying, Chen Pan, Zeng Hang, Tan Hua-sen, Gonzalez Frank J, Huang Min, Bi Hui-chang*. Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration. Toxicol Sci. 2015 Jan;143(1):107-15