药物化学

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洪 亮 [副教授]

洪  亮

联系方式

办公电话:020-39943529

电子邮箱:hongliang@mail.sysu.edu.cn

办公地址:

简单介绍

洪亮 博士,副教授,中山大学百人计划二期引进人才,硕士生导师。

研究方向

1.多肽生物化学与药物化学;2.基于活性导向的有机合成方法学研究;3.多肽药物与手性药物的研发及产业化关键技术。

论著专利

1、Wangsheng Sun,† Liang Hong,† Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni,* and Rui Wang*. An Organocatalytic Michael−Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters. Org. Lett. 2014, 16, 544-547.

2、Wu Chongyang, Li Guofeng, Sun Wangsheng, Zhang Ming, Hong Liang,* Wang Rui*. Organocatalytic Highly Enantioselective Monofluoroalkylation of 3 Bromooxindoles: Construction of Fluorinated 3,3’-Disubstituted Oxindoles and Their derivatives. Org. Lett. 2014, 16, 1960-1963.

3、Wangsheng Sun, Gongming Zhu, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones. Angew. Chem. Int. Ed. 2013, 52, 8633-8637.

4、Hailong Zhang,†Liang Hong,†Hong Kang, and Rui Wang*. Construction of Vicinal All-Carbon Quaternary Stereocenters by Catalytic Asymmetric Alkylation Reaction of 3-Bromooxindoles with 3-Substituted Indoles: Total Synthesis of (+)-Perophoramidine. J. Am. Chem. Soc. 2013, 135, 14098-14101.(Most Read Article; Highlight by Synfacts)

5、Liang Hong,* Ming Kai, Chongyang Wu, Wangsheng Sun, Gongming Zhu, Guofeng Li, Xiaojun Yao and Rui Wang* . Enantioselective 1,3-Dipolar Cycloaddition of Methyleneindolinones and N,N’-Cyclic Azomethine Imines. Chem. Commun. 2013, 49, 6713-6715.(封面文章)

6、Gongming Zhu, Wangsheng Sun, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Base-Catalyzed Diastereoselective [3+3] Annulation of 3-Isothiocyanato oxindoles and Azomethine Imines. Org. Lett. 2013, 15, 4988-4991.

7、Liang Hong,* and Rui Wang*. Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles. Adv. Synth. Catal. 2013, 355, 1023-1052.(封面文章)

8、Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*.“Organo-Metal”Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles. Chem. Eur. J. 2012, 18, 13959-13963.(Most Accessed Article)

9、Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers. Chem. Eur. J. 2012, 18, 6737-6741.

10、Wangsheng Sun, Gongming Zhu, Liang Hong,* and Rui Wang*. The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine-Metal Cooperative Catalysis. Chem. Eur. J. 2011, 17, 13958-13962.(Most Accessed Article)

11、Wangsheng Sun, Xiaozhou Ma, Liang Hong,* and Rui Wang*. Asymmetric Organocatalytic Allylic Substitution of Morita-Baylis-Hillman Carbonates with Allylamines for the Synthesis of 2,5-Dihydropyrroles. J. Org. Chem. 2011, 76, 7826-7833 (SCI, IF 4.564)

12、Hong Liang, Sun Wangsheng, Liu Chunxia, Zhao Depeng, Wang Rui*. Enantioselective Construction of Allylic Phosphine Oxides through Substitution of Morita–Baylis–Hillman Carbonates with Phosphine Oxides. Chem. Commun. 2010, 46, 2856-2858.

13、Hong Liang, Sun Wangsheng, Liu Chunxia, Wang Lei, Wang Rui*. Asymmetric Organocatalytic N-alkylation of Indole-2-carbaldehydes withα,β-Unsaturated Aldehydes: One-pot Synthesis of Chiral Pyrrolo[1,2-a]indole-2-carbaldehydes. Chem. Eur. J. 2010, 16, 440-444.

14、Hong Liang, Liu Chunxia, Sun Wangsheng, Wang Lei, Wong Kwokyin, Wang Rui*.  Organocatalytic Enantioselective Friedel-Crafts Alkylation of 4,7-Dihydroindoles withα,β-Unsaturated Aldehydes: An Easy Access to 2-Substituted Indoles. Org. Lett. 2009, 11, 2177-2180.

15、Hong Liang, Sun Wangsheng, Liu Chunxia, Wang Lei, Wong Kwokyin, Wang Rui*. Enantioselective Friedel-Crafts Alkylation of 4,7-Dihydroindoles with Enones Catalyzed by Primary-secondary Diamines. Chem. Eur. J. 2009, 15, 11105-11108.(Most Accessed Article)

16、Hong Liang, Wang Lei, Chen Chao, Zhang Bangzhi, Wang Rui*. An Efficient Enantioselective Method for Asymmetric Friedel-Crafts Alkylation of Indoles withα,β-unsaturated Aldehydes. Adv. Synth. Catal. 2009, 351, 772-778.

17、Hong Liang, Wang Lei, Sun Wangsheng, Wong Kwokyin, Wang Rui*. Organocatalytic Asymmetric Friedel-Crafts Alkylation/cyclization Cascade Reaction of 1-Naphthols andα,β-unsaturated Aldehydes: An Enantioselective Synthesis of Chromanes and Dihydrobenzopyranes. J. Org. Chem. 2009, 74, 6881-6884.

获奖情况

2013教育部自然科学奖一等奖(排名第三)

2013中国药学会科学技术奖一等奖(排名第四)