药剂学

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冯 敏 [教授]

冯  敏

联系方式

办公电话:020-39943119(o)

电子邮箱:fengmin@mail.sysu.edu.cn

办公地址:广州市城外环东路132号中山大学药学院 510006

简单介绍

冯敏, 博士,教授。1997年毕业于中国药科大学,获学士学位。2001年毕业于中山大学,获生物医学工程博士学位。2002年1月-2004年8月先后在新加坡南洋理工大学和香港理工大学应用生物及化学系进行博士后研究工作,从事纳米粒抗肿瘤药物制剂和基因药物递送系统的研究。2010年1月- 6月在美国普渡大学药学院做访问学者,进行纳米递送系统的肿瘤基因治疗研究。2004年 9月任职于中山大学药学院药剂教研室和制剂工程研究室。担任广东省药学会制剂专业委员会委员,广州市科技评审专家等。近年来主持国家及省部级课题8项,参与国家级课题6项。发表SCI论文40余篇,其中20余篇影响因子大于3.0。

研究方向

核酸、多肽和蛋白药物传递系统理论与新制剂的研究

教学情况

本科生课程:药剂学、物理化学、药用高分子与新型给药系统、药物制剂设计与实例

研究生课程:药用高分子材料、药剂学进展

科研项目

1.     国家自然科学基金:基于肿瘤微环境调控的功能转换型杂化多肽聚电解质刷载MDR1 siRNA逆转结肠癌多药耐药性的递送机制研究,主持,起止时间:2014.01-2017.12。

2.     国家高技术研究发展技术(863计划):药食同源生物资源活性成分高效利用制剂关键技术研究,主持,起止时间:2014.01-2016.12。

3.     国家自然科学基金:嵌合载体纳米粒基因传递系统的构建及在基因搭桥中的作用,主持,起止时间:2007.01-2009.12。

4.     广东省自然科学基金:聚酰胺-胺纳米粒介导MDR1siRNA逆转结肠癌多药耐药性研究,主持人,起止时间:2012.10-2014.10。

5.     高校基本业务费青年教师重点培育项目:多功能聚谷氨酰胺聚电解质刷递送siRNA双靶标逆转结肠癌多药耐药性的研究,主持,起止时间:2013.08-2015.08。

6.     高校基本业务费青年教师培育项目:维生素B12纳米粒口服递送胰岛素及其机制的研究,主持,起止时间:2010.01-2012.12。

7.     广东省自然科学基金:靶向肺腺癌TK基因转移纳米粒吸入剂的研究,主持,起止时间:2007.01-2008.12。

8.     国家自然科学基金:聚酰胺-胺树枝状高分子的化学修饰和基因传导系统性能的研究,主要成员(第二),起止时间:2009.01-2011.12。

9.     国家自然科学基金:聚乙二醇-聚乙烯亚胺/基因传递系统的优化及防治血管再狭窄的研究,主要成员(第二),起止时间:2006.01-2008.12。

论著专利

1.  Huang H, Cao D, Qin L, Tian S, Liang Y, Pan S*, Feng M*. Dilution-stable PAMAMG1-grafted polyrotaxane supermolecules deliver gene into cells through a caveolae-dependent pathway. Mol. Pharm. 2014 [Epub ahead of print]

2.  Feng M, Ibrahim BM, Wilson EW, Doh KO, Bergman BK, Park C, Yeo Y. Stabilization of a hyaluronate-associated gene delivery system using calcium ions. Biomater Sci. 2014, 2, 936–942

3.  Zhao Y, Qin Y, Liang Y, Zou H, Peng X, Huang H, Lu M, Feng M*. Salt-induced stability and serum-resistance of polyglutamate polyelectrolyte brushes/nuclear factor-κB p65 siRNA polyplex enhance the apoptosis and efficacy of doxorubicin.Biomacromolecules. 2013, 14 (6): 1777–1786(IF: 5.371)

4.  Wen Y, Guo Z, Du Z, Fang R, Wu H, Zeng X, Wang C, Feng M*, Pan S*. Serum tolerance and endosomal escape capacity of histidine-modified pDNA-loaded complexes based on polyamidoamine dendrimer derivatives. Biomaterials. 2012, 33(32):8111-8121(IF: 7.604)

5.  Wang C, Luo X, Zhao Y, Han L, Zeng X, Feng M*, Pan S, Peng H*, Wu C. Influence of the polyanion on the physico-chemical properties and biological activities of polyanion/DNA /polycation ternary polyplexes. Acta Biomater. 2012, 8(8): 3014-3026(IF:5.093)

6.  Xu M, Zhao Y, Feng M*. Polyaspartamide derivative nanoparticles with tunable surface charge achieve highly efficient cellular uptake and low cytotoxicity. Langmuir. 2012, 28(31): 11310-11318(IF: 4.187)

7.   Deng J, Wen Y, Wang C, Pan S, Gu H, Zeng X, Feng M*, Wu C. Efficient intracellular gene delivery using the formulation c omposed of poly (L-glutamic acid) grafted polyethylenimine and histone. Pharm Res. 2011, 28(4): 812-826(IF: 4.742)

8.   Shen Y, Peng H, Pan SR, Feng M*, Deng J, Wen YT, Luo X, Wu C. Interaction of DNA/nuclear protein/polycation and the terplexes for gene delivery. Nanotechnology. 2010, 21(4): 045102(IF: 3.842)

9.   Pan S*, Cao D, Huang H, Yi W, Qin L, Feng M*. A serum-resistant low-generation polyamidoamine with PEI 423 outer layer for gene delivery vector. Macromol Biosci. 2013,13(4): 422-36(IF: 3.742)

10.Han L, Zhao Y, Yin L, Li R, Liang Y, Huang H, Pan S, Wu C, Feng M*. Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery. AAPS PharmSciTech. 2012, 13(3): 836-845(IF: 1.432)

11.Zeng X, Pan S*, Li J, Wang C, Wen Y, Wu H, Wang C, Wu C, Feng M*. A novel dendrimer based on poly (L-glutamic acid) derivatives as an efficient and biocompatible gene delivery vector. Nanotechnology. 2011, 22(37): 375102(IF: 3.842)

12.Pan S*, Wang C, Zeng X, Wen Y, Wu H, Feng M*. Short multi-armed polylysine-graft-polyamidoamine copolymer as efficient gene vectors. Int J Pharm. 2011, 420(2): 206-215(IF: 3.458)

13. Wang C, Feng M*, Deng J, Zhao Y, Zeng X, Han L, Pan S, Wu C. Poly (α-glutamic acid) combined with polycation as serum-resistant carriers for gene delivery. Int J Pharm. 2010, 398(1-2): 237-245(IF: 3.458)

14. Shen Y, Peng H, Deng J, Wen YT, Luo X, Pan SR, Wu CB, Feng M*. High mobility group box 1 protein enhances polyethylenimine mediated gene delivery in vitro. Int. J Pharm. 2009, 375(1-2): 140-147(IF: 3.458)

15. Shen Y, Deng J, Luo X, Zeng X, Feng M*, Pan S. Synthesis and characterization of sterically stabilized polyelectrolyte using isophorone diisocyanate as the coupling reagent. J Biomat Sci. Polym Ed. 2009, 20(9): 1217-1233(IF: 1.98)

16.  韩丽娜,尹丽芳,赵月芳,梁扬,黄欢, 冯敏*. 胰岛素/维生素B12-透明质酸纳米粒的制备及口服给药体内外性质的评价. 中山大学学报(医学科学版). 2012, 33(5): 597-602. (CSA收录)

17. 沈媛, 彭辉, 冯敏*, 邓晶晶, 温玉婷, 曾昕, 罗昕. 构建HMGB1 /PEI非病毒载体介导高效基因传递的研究.中山大学学报(自然科学版). 2009, 48(5): 91-96.(EI收录)

18.Luo X, Feng M, Pan S*, Wen Y, Zhang W, Wu C. Charge shielding effects on gene delivery of polyethylenimine/DNA complexes: PEGylation and phospholipid coating. J Mater Sci Mater Med. 2012, 23(7): 1685-1695

19.Li J*, Yang G, Feng M, Liang H, Zhang J, Huang D, Deng S, Shen Y. LDL coating pVEGF/polyethylenimine complex enhances vascular endothelial growth factor expression. Biotech Bioproc Eng. 2012, 17(6):1182-1189

20.Pan S, Cao D, Yi W, Huang H, Feng M. A biodegradable and serum-resistant gene delivery carrier composed of polyamidoamine-poly N, N-di-(2-aminoethyl) aminoethyl glutamine copolymer. Colloids Surf B Biointerfaces. 2012, 104C: 294-302Tan Y, Yang Z, Pan X, Chen M, Feng M, Wang L, Liu H, Shan Z, Wu C*. Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process. Int J Pharm. 2012, 427(2): 385-392

21.Tan Y, Yang Z, Peng X, Xin F, Xu Y, Feng M, Zhao C, Hu H, Wu C*. A novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants. Int J Pharm. 2011, 413(1-2): 167-173

22.Luo X, Pan S*, Feng M, Wen Y, Zhang W. Stability of poly(ethylene glycol)-graft -polyethylenimine copolymer/DNA complexes: influences of PEG molecular weight and PEGylation degree. J Mater Sci: Mater Med. 2010, 21(2): 597–607

23.Guosen H, Feng M, Luo X, Venkatraman S*. Design, synthesis and in vitro evaluation of a novel "stealth" polymeric gene vector. Int J Pharm. 2008, 350(1-2): 344–350

24.Wen Y, Pan S*, Luo X, Zhang X, Zhang W, Feng M. A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector. Bioconjug Chem. 2009, 20(2): 322-332

25.Zhang X, Pan SR, Hu HM, Wu GF, Feng M, Zhang W, Luo X. Poly(ethylene glycol)-block –poly ethylenimine copolymers as carriers for gene delivery: Effects of PEG molecular weight and PEGylation degree. J Biomed Mater Res A. 2008, 84(3): 795-804.

26.Feng M and Li P. Amine-Containing Core-Shell Nanoparticles as Potential Drug Carriers for Intracellular Delivery. J Biomed Mater Res Part A. 2007, 80(1): 184-93

27. 冯敏,王玉洁,彭辉. PEI-PLGA阳离纳米粒介导宫颈癌细胞基因转染效率的研究. 中国药学杂志, 2007, 42(5): 32-36

28. Siu YS, Feng M, Peng X.  Efficient gene delivery using a novel core-shell nanoparticle and HMGB1 system. FASEB J. 2006, 20 (4): A526-A526.

29. Feng M, Lee D and Li P. Intracellular uptake and release of poly (ethyleneimine) –co- poly (methyl methacrylate) nanoparticle/pDNA complexes for gene delivery. Int J Pharm. 2006, 311(1-2): 209-214.

30. Pan J, Venkatraman SS, Feng M. Micelle-like nanoparticles of star-branched PEO–PLA copolymers as chemotherapeutic carrier.  J Control Release. 2005, 111(1): 511-524

31.Venkatraman SS, Pan J, Feng M. Micelle-like nanoparticles of PLA–PEG–PLA triblock copolymer as chemotherapeutic carrier. Int J Pharm. 2005, 298(1): 219-232

32.Zhu JM, Tang A, Feng M, et al. Amphiphilic Core-Shell Nanoparticles with Poly(ethylenimine) Shells as Potential Gene Delivery Carriers. Bioconjugate Chem.  2005, 16(1): 139-146